Results 61 to 70 of about 653,174 (341)

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Hepatosplenic sarcoidosis complicated by liver cirrhosis [PDF]

, 2015
Sarcoidosis is a multisystemic disease usually affecting the lungs and mediastinal lymph nodes. Other organs, such as the liver and the spleen, are less commonly involved. Patients usually present with mild nonspecific symptoms.
Bernard, Philippe, Peters, Benjamin, Van Dijck, Herwig, Van Overbeke, Lode, Vanhoenacker, Filip   +4 more
core   +3 more sources

Lower free triiodothyronine (fT3) levels in cirrhosis are linked to systemic inflammation, higher risk of acute-on-chronic liver failure, and mortality [PDF]

, 2023
Lukas Hartl, Benedikt Simbrunner, Mathias Jachs, Peter Wolf, David Bauer, Bernhard Scheiner, Lorenz Balcar, Georg Semmler, Michael Schwarz, Rodrig Marculescu, Varius Dannenberg, Michael Trauner, Mattias Mandorfer, Thomas Reiberger   +13 more
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

When the heart kills the liver: acute liver failure in congestive heart failure

European Journal of Medical Research, 2009
Congestive heart failure as a cause of acute liver failure is rarely documented with only a few cases. Although the pathophysiology is poorly understood, there is rising evidence, that low cardiac output with consecutive reduction in hepatic blood flow ...
Saner FH, Heuer M, Meyer M, Canbay A, Sotiropoulos GC, Radtke A, Treckmann J, Beckebaum S, Dohna-Schwake C, Oldedamink SW, Paul A   +10 more
doaj   +1 more source

Hemophagocytic Lymphohistiocytosis in the Medical ICU: A Single-Institution Cohort Study on Acute Liver Failure and Mortality

Critical Care Explorations, 2021
Objectives:. Hemophagocytic lymphohistiocytosis is a life-threatening hyperinflammatory disorder that is associated with high morbidity and mortality in the ICU. It has also been associated with acute liver failure. Design:.
Nawar Al Nasrallah, MD, Ahmad Al-Hader, MD, Niharika Samala, MBBS, Catherine R. Sears, MD, ATSF   +3 more
doaj   +1 more source

A clinicopathological study of human liver allograft recipients harboring preformed IgG lymphocytotoxic antibodies [PDF]

, 1992
Twenty‐six adult patients with preformed IgG donor lymphocytotoxic antibodies received primary liver allografts under FK 506 immunosuppression. The effect of the crossmatch‐positive state on early graft function and on the immunopathological and ...
Batts, Bird, Busch, Cerilli, Demetris, Demetris, Demetris, Dempster, Donaldson, Eggink, Giles, Gordon, Gubernatis, Gugenheim, Gugenheim, Hanto, Houssin, Ito, Iwaki, Iwatsuki, Kakizoe, Kissmeyer-Nielsen, Knechtle, Okuno, Simpson, Snover, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Takaya, Takaya, Takaya, Terada, Terasaki, Todo, Weber, Williams   +40 more
core   +1 more source

Acute liver failure- an interesting case report [PDF]

, 2022
Aastha Jha, Maitrey Patel, Alok Sahu, Apurva Shahm, Shravan Bohra   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Acute-on-chronic liver failure: a review

Therapeutics and Clinical Risk Management, 2014
Luis Eduardo Zamora Nava,1 Jonathan Aguirre Valadez,2 Norberto C Chávez-Tapia,3 Aldo Torre21Department of Endoscopy, 2Department of Gastroenterology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, 3Obesity and ...
Zamora Nava LE, Aguirre Valadez J, Chávez-Tapia NC, Torre A   +3 more
doaj