Results 91 to 100 of about 541,112 (308)

Artificial Intelligence in Systemic Sclerosis: Clinical Applications, Challenges, and Future Directions

Arthritis Care &Research, EarlyView.
Systemic sclerosis (SSc) is a rare autoimmune disease defined by immune dysregulation, vasculopathy, and progressive fibrosis of the skin and internal organs. Despite advances in care, major complications such as interstitial lung disease (ILD) and myocardial involvement remain the leading causes of morbidity and mortality.
Cristiana Sieiro Santos, José Miguel Sequí‐Sabater, Diego Benavent   +2 more
wiley   +1 more source

Clinical and ventilator waveforms of Chinese patients during pressure support ventilation

Scientific Data
In the field of critical care medicine, accurate analysis of physiological waveform data is crucial for clinical decision-making. Although existing public databases provide a wealth of physiological waveform data, publicly available ventilator waveform ...
Xiaozhu Liu, Peng Wang, Chenjia Hao, Ming-Yue Miao, Xu An, Shan-Shan Xu, Yuefu Wang, Hong-Liang Li, Zongmei Tian, Jian-Xin Zhou   +9 more
doaj   +1 more source

A cluster randomized trial on inspiratory effort-targeted pressure support adjustment strategy in patients undergoing assisted mechanical ventilation: protocol for the IT-PSV study

Frontiers in Medicine
BackgroundPressure support ventilation (PSV) is one of the most frequently used ventilator modes in the intensive care unit (ICU). The successful implementation of PSV depends on matching the patient’s inspiratory effort with the ventilator support.
Wen-Yi Lu, Wen-Yi Lu, Ming-Yue Miao, Ran Gao, Yan-Lin Yang, Linlin Zhang, Li Weng, Feng-Xue Zhu, Lei Liu, Jian-Xin Zhou   +9 more
doaj   +1 more source

Polydatin up-regulates clara cell secretory protein to suppress phospholipase A2 of lung induced by LPS in vivo and in vitro [PDF]

, 2011
Background Lung injury induced by lipopolysaccharide (LPS) remains one of the leading causes of morbidity and mortality in children. The damage to membrane phospholipids leads to the collapse of the bronchial alveolar epithelial barrier ...
Shu Shiyu, Ling Zhiyu, Ye Mao, Bo Lin, Wang Lijia, Zhang Tianbao, Chen Jie, Li Tingyu   +7 more
core   +2 more sources

Ultrasmall Platinum Nanoparticles for Radiation‐Enhanced Cancer Therapy

Advanced Functional Materials, EarlyView.
This work proposes a nanomedicine‐based strategy to enhance X‐ray radiotherapy for cancer treatment. Ultrasmall Pt‐NPs exhibit catalase‐like activity that may contribute to modulation of the tumor microenvironment and amplify interactions between radiation and biological matter, leading to increased DNA damage.
Miguel Encinas‐Gimenez, Jose I. Garcia‐Peiro, Jose L. Hueso, Eduardo Caleiras, Laura Notario, Felipe Hornos, Pilar Martin‐Duque, Antonio De la Vieja, Jesus Santamaria   +8 more
wiley   +1 more source

Transfusion related acute lung injury presenting with acute dyspnoea: a case report

Journal of Medical Case Reports, 2008
Introduction Transfusion-related acute lung injury is emerging as a common cause of transfusion-related adverse events. However, awareness about this entity in the medical fraternity is low and it, consequently, remains a very under-reported and often an
Haji Altaf, Sharma Shekhar, Vijaykumar DK, Paul Jerry   +3 more
doaj   +1 more source

Involvement of leukotriene pathway in the pathogenesis of ischemia-reperfusion injury and septic and non-septic shock. [PDF]

, 2009
The 5-lipoxygenase (5-LO) pathway is responsible for the production of leukotrienes (LTs), inflammatory lipid mediators which play a role in innate immunity. More recently, a pivotal role of LTs in ischemia-reperfusion and shock injury has been suggested.
CUZZOCREA S, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA   +2 more
core   +1 more source

The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. [PDF]

, 2020
The respiratory system, which includes the trachea, airways, and distal alveoli, is a complex multi-cellular organ that intimately links with the cardiovascular system to accomplish gas exchange.
Basil, Maria C, Chapman, Hal A, Engler, Anna E, Guo, Minzhe, Herriges, Michael J, Kathiriya, Jaymin J, Katzen, Jeremy, Kotton, Darrell N, Morrisey, Edward E, Rock, Jason R, Snoeck, Hans-Willem, Vunjak-Novakovic, Gordana, Whitsett, Jeffrey A, Windmueller, Rebecca, Ysasi, Alexandra B, Zacharias, William J   +15 more
core   +2 more sources

Bioactive Conductive Ti3C2Tx‐Ce Hydrogel Facilitates Spinal Cord Injury Repair Through ROS Scavenging and Mitochondrial Regulation

Advanced Functional Materials, EarlyView.
Bioactive conductive Ti3C2Tx‐Ce hydrogels with with scavenging ROS and alleviating neuronal mitochondrial dysfunction are exploited for SCI treatment. This functionality is attributed to interfacial activation modification of Ti3C2Tx with Ce3+ ions to in‐situ form Ce(OH)x‐mediated protective layer, which is beneficial to enabling stable intracellular ...
Weikang Wang, Qing Liu, Ang Lv, Yabin Lin, Jiawei Chen, Ning Ding, Chunlei Zhang, Shuai Zhou, Bo Yuan, Weiwei Zhao, Liming Li, Luping Zhang, Fei Huang   +12 more
wiley   +1 more source

Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury

Nature Communications
An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes and platelets (Mgk/plt) play important roles in hemostasis, their impact on the matrix in lung injury is not fully ...
Hernán F. Peñaloza, Atish Gheware, Ananya Gupta, Donovan Watza, Anupam Kumari, Shekina Gonzalez-Ferrer, Zeyu Xiong, Xingan Wang, Gregory Gibson, Pooja Bhojraj, Rick van der Geest, Jae-Sung Kim, Bo-Ram Jin, Mélia Magnen, William G. Bain, Mohammadreza Tabary, Liwen Zhang, Arpad Somogy, Tomasz Kaminski, Prithu Sundd, Kyunghee Choi, Anuradha Ray, Prabir Ray, Rama K. Mallampalli, Sebastien Gingras, Matthew R. Rosengart, Mark R. Looney, Jonathan K. Alder, Jaehyung Cho, Claudette St. Croix, Janet S. Lee   +30 more
doaj   +1 more source