Results 81 to 90 of about 318,103 (313)

A consensus redefinition of transfusion‐related acute lung injury

Transfusion, 2019
Transfusion‐related acute lung injury (TRALI) is a serious complication of blood transfusion and is among the leading causes of transfusion‐related morbidity and mortality in most developed countries.
A. Vlaar, P. Toy, M. Fung, M. Looney, N. Juffermans, J. Bux, P. Bolton-Maggs, A. Peters, C. Silliman, D. Kor, S. Kleinman   +10 more
semanticscholar   +1 more source

Megakaryocyte and platelet thrombospondin-1 regulates matrix remodeling by stabilizing basement membrane COL6A1 in lung injury

Nature Communications
An early event after lung injury is extracellular matrix (ECM) remodeling and the formation of a provisional matrix. While megakaryocytes and platelets (Mgk/plt) play important roles in hemostasis, their impact on the matrix in lung injury is not fully ...
Hernán F. Peñaloza, Atish Gheware, Ananya Gupta, Donovan Watza, Anupam Kumari, Shekina Gonzalez-Ferrer, Zeyu Xiong, Xingan Wang, Gregory Gibson, Pooja Bhojraj, Rick van der Geest, Jae-Sung Kim, Bo-Ram Jin, Mélia Magnen, William G. Bain, Mohammadreza Tabary, Liwen Zhang, Arpad Somogy, Tomasz Kaminski, Prithu Sundd, Kyunghee Choi, Anuradha Ray, Prabir Ray, Rama K. Mallampalli, Sebastien Gingras, Matthew R. Rosengart, Mark R. Looney, Jonathan K. Alder, Jaehyung Cho, Claudette St. Croix, Janet S. Lee   +30 more
doaj   +1 more source

Transfusion-related acute lung injury – afrequently undiagnosed reaction following transfusion ofblood components

Pediatria i Medycyna Rodzinna, 2015
Transfusion-related acute lung injury is the leading cause of mortality following transfusion of blood components. Its characteristic feature is acute hypoxaemia during or 6 hours after transfusion.
Jolanta Korsak, Anna Łata
doaj   +1 more source

Tofacitinib reduces acute lung injury and improves survival in a rat model of sepsis by inhibiting the JAK-STAT/NF-κB pathway

Journal of Inflammation, 2023
Acute lung injury is a major cause of death in sepsis. Tofacitinib (TOFA), a JAK inhibitor, has anti-inflammatory activity in autoimmune diseases, but its role in acute lung injury in sepsis remains unclear.
Xinxin Zhang, Xingsheng Wang, Li Sun, Guangsheng Gao, Yun Li   +4 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Neutrophils and galectin-3 defend mice from lethal bacterial infection and humans from acute respiratory failure

Nature Communications
Respiratory infection by Pseudomonas aeruginosa, common in hospitalized immunocompromised and immunocompetent ventilated patients, can be life-threatening because of antibiotic resistance.
Sudipta Das, Tomasz W. Kaminski, Brent T. Schlegel, William Bain, Sanmei Hu, Akruti Patel, Sagar L. Kale, Kong Chen, Janet S. Lee, Rama K. Mallampalli, Valerian E. Kagan, Dhivyaa Rajasundaram, Bryan J. McVerry, Prithu Sundd, Georgios D. Kitsios, Anuradha Ray, Prabir Ray   +16 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Differential effects of extracellular vesicles from aging and young mesenchymal stem cells in acute lung injury

Aging, 2019
Old age is a known risk factor for mortality in acute respiratory distress syndrome (ARDS)/acute lung injury. Mesenchymal stem cells (MSCs) possess potent immunomodulatory properties, while aging MSCs have reduced capacity.
Ruoqiong Huang, Chaojin Qin, Jiangmei Wang, Yaoqin Hu, G. Zheng, Guanguan Qiu, Menghua Ge, Huikang Tao, Q. Shu, Jianguo Xu   +9 more
semanticscholar   +1 more source

Use of pressure muscle index to predict the contribution of patient’s inspiratory effort during pressure support ventilation: a prospective physiological study

Frontiers in Medicine
BackgroundThe successful implementation of assisted ventilation depends on matching the patient’s effort with the ventilator support. Pressure muscle index (PMI), an airway pressure based measurement, has been used as noninvasive monitoring to assess the
Ran Gao, Ran Gao, Jian-Xin Zhou, Yan-Lin Yang, Shan-Shan Xu, Yi-Min Zhou, Linlin Zhang, Ming-Yue Miao   +7 more
doaj   +1 more source

Neutrophils in acute lung injury

Frontiers in Bioscience, 2012
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is characterised by lung oedema due to increased permeability of the alveolar-capillary barrier and subsequent impairment of arterial oxygenation. Lung oedema and endothelial and epithelial injury are accompanied by an influx of neutrophils into the interstitium and alveolar space ...
Xiaohong, Zhou, Qingchun, Dai, Xinli, Huang   +2 more
openaire   +2 more sources