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Seminars in Respiratory and Critical Care Medicine, 2006
Acute lung injury (ALI) is a complex syndrome involving the interplay of both environmental (such as the addition of mechanical ventilation) and genetic factors. Clinical models have identified risk factors for development and poor outcome but these strategies remain imprecise.
Carlos, Flores +4 more
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Acute lung injury (ALI) is a complex syndrome involving the interplay of both environmental (such as the addition of mechanical ventilation) and genetic factors. Clinical models have identified risk factors for development and poor outcome but these strategies remain imprecise.
Carlos, Flores +4 more
openaire +2 more sources
Mechanisms of acute lung injury
Current Opinion in Critical Care, 1997Acute lung injury is the end result of common pathways initiated by a variety of local or systemic insults leading to diffuse damage to the pulmonary parenchyma. Despite the accumulation of abundant information regarding the physiological and cellular basis of lung injury and increasingly sophisticated intensive care, an improvement in prognosis has ...
G P, Downey, J T, Granton
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Autophagy in Acute Lung Injury
Cell Biochemistry and BiophysicsAcute lung injury (ALI) is a critical condition marked by rapid-onset respiratory failure due to extensive inflammation and increased pulmonary vascular permeability, often progressing to acute respiratory distress syndrome (ARDS) with high mortality.
Danjuan, Liu +6 more
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Epidemiology of acute lung injury
Current Opinion in Critical Care, 2005Acute lung injury and its extreme manifestation, acute respiratory distress syndrome, complicate a wide variety of serious medical and surgical conditions, only some of which affect the lung directly. Despite recent evidence-based advances in clinical management, acute lung injury and acute respiratory distress syndrome are associated with significant ...
Niall S, MacCallum, Timothy W, Evans
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Glucocorticoids and acute lung injury
Critical Care Medicine, 2003To describe hypothalamic-pituitary-adrenal (HPA) activation and the role of glucocorticoids in immune modulation during critical illness, and to review clinical trials of pharmacologic and "replacement"' doses of glucocorticoids in early and late acute respiratory distress syndrome (ARDS) and sepsis.Selected review of published literature (1963 to ...
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Lactate Production by the Lungs in Acute Lung Injury
American Journal of Respiratory and Critical Care Medicine, 1997Abstract Arteriovenous differences in lactate (AVLAC) across the lungs are usually small and close to zero. However, it has recently been reported that the lungs can produce increased amounts of lactate in some patients with acute respiratory distress syndrome (ARDS). The aim of this study was to evaluate lactate production in various
De Backer, Daniel +4 more
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Epidemiology of acute lung injury
Critical Care Medicine, 2003To review the epidemiology of acute lung injury (ALI) with particular emphasis on its effect on public health.Published studies on the definitions, incidence, and outcomes of ALI.ALI is a syndrome of acute hypoxemic respiratory failure that is not primarily cardiac in origin. The diagnostic criteria for the syndrome have not been well studied for their
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Transfusion-Related Acute Lung Injury
Current Opinion in Hematology, 2000Transfusion-related acute lung injury is a life-threatening complication of hemotherapy associated with the transfusion of plasma-containing blood products. It is characterized by acute respiratory distress, pulmonary edema and hypoxemia. Although its frequency is unknown, Food and Drug Administration data suggest that it is the third most common cause
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