Results 111 to 120 of about 6,391 (198)
Andrology, EarlyView.Abstract Background Imatinib and dasatinib are tyrosine kinase inhibitors (TKIs) increasingly used to treat several diseases in both children and adults at fertile age. We have previously shown that imatinib has adverse effects on developing testis, and imatinib‐treated male patients have been reported to have reduced sperm counts.
Anna Eggert +10 more
wiley +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Carriage of any loss of function NUDT15 varaint is associated with an increased risk of thiopurine‐induced myelosuppression. Pre‐treatment genotype testing of NUDT15. ABSTRACT Background The clinical utility and cost‐effectiveness of pre‐thiopurine NUDT15 pharmacogenetic testing in European and admixed populations are unknown.
Christopher Roberts +32 more
wiley +1 more source
British Journal of Haematology, EarlyView.Proposed management of newly diagnosed Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukaemia (ALL) in transplant‐eligible patients. Suggested considerations when deciding the treatment pathway available to a newly diagnosed Ph+ ALL patient that would be deemed transplant eligible. Summary Acute lymphoblastic leukaemia (ALL) in 20%–30% of
Naranie Shanmuganathan, Andrew Grigg
wiley +1 more source
British Journal of Haematology, EarlyView.To identify pathogenic somatic and germline gene variants associated with blast‐phase transformation and cancer predisposition in paediatric chronic myeloid leukaemia (CML), n = 19 patients with blast‐phase paediatric CML were analysed with whole genome and targeted panel sequencing and compared to n = 19 patients with chronic phase paediatric CML.
Yvonne Lisa Behrens +22 more
wiley +1 more source
The role of blinatumomab in adult acute B lymphoblastic leukaemia
British Journal of Haematology, EarlyView.Blinatumomab, a CD19‐directed bispecific T‐cell engager, has become a crucial part of BCP‐ALL therapy in r/r disease, MRD‐positive disease and has recently been implemented into first‐line therapy of BCP‐ALL. This review discusses important clinical trials with a focus on blinatumomab in first‐line therapy of adult BCP‐ALL.
Anne C. Wilke, Nicola Gökbuget
wiley +1 more source
Anaplastic large cell lymphoma in children and adolescents
British Journal of Haematology, EarlyView.Summary Anaplastic lymphoma kinase (ALK)‐positive anaplastic large‐cell lymphoma (ALCL) accounts for >95% of ALCL cases in children and adolescents. The first description of ALCL as a CD30‐positive lymphoma in 1985 was followed by the detection of chromosomal translocations involving the ALK gene at chromosome 2p23.
Eric J. Lowe, Wilhelm Woessmann
wiley +1 more source
Hematology, Transfusion and Cell TherapyBackground: Acute lymphoblastic leukemia is the predominant neoplastic ailment in childhood. Prior research has already established noteworthy connections between CDKN2A polymorphisms and susceptibility to this childhood leukemia, however, substantial ...
Maryam Aghasipour +11 more
doaj
British Journal of Haematology, EarlyView.This study demonstrates the clinical utility of a next‐generation sequencing (NGS)‐based chimerism assay (CASAL) in haematopoietic stem cell transplantation (HSCT). Compared to conventional short tandem repeat (STR) methods, CASAL showed significantly higher marker informativeness, detecting mixed chimerism (MC) below 5% recipient DNA with a median of ...
Jin Ju Kim +7 more
wiley +1 more source
British Journal of Haematology, EarlyView.We report the UK experience of autologous haematopoietic stem cell transplantation (AHSCT) for multiple sclerosis (MS) in 364 patients. In our observational study, transplant‐related mortality was 1.4%, Epstein–Barr virus reactivation occurred in 75.9%, while disability progression‐free survival was 83.5% at 2 years post‐AHSCT and 62.4% at 5 years.
Majid Kazmi +18 more
wiley +1 more source
Risk Factors for Traumatic Lumbar Puncture in Children With ALL
Acta Paediatrica, EarlyView.
Sirkku Setänen +3 more
wiley +1 more source