Results 131 to 140 of about 124,423 (315)

Leucemia Linfoblástica aguda recidivada tratada com rituximab: relato de caso e revisão de literatura. [PDF]

, 2007
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Borbinhão, Rodrigo Widholzer
core  

Metabolic feature profiling and metabolic vulnerability in acute lymphoblastic leukemia

Interdisciplinary Medicine, EarlyView.
For the first time, our study develops a novel metabolic classification and subtyping program, metabolic reprogramming‐based classifier for acute lymphoblastic leukemia, using internal PDT‐ALL‐2016 and external cohorts, which dissects metabolic profiling, clinical outcome, and therapeutic vulnerability for precision metabolic intervention in ALL ...
Xiaojie Liang, Zihong Cai, Bingqing Tang, Zicong Huang, Baiwei Luo, Bingyu Lin, Yunong Yang, Zhihao Jin, Xiaoqing Li, Xiuli Xu, Yeling Deng, Chaoran Lin, Liang Wang, Hongsheng Zhou   +13 more
wiley   +1 more source

Blinatumomab in acute lymphoblastic leukemia [PDF]

Expert Review of Anticancer Therapy, 2016
Thomas, Xavier, Lejeune, Caroline
openaire   +3 more sources

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia [PDF]

, 2013
Blair, Allison, Moppett, John P, Diamanti, Paraskevi, Cox, Charlotte V   +3 more
core   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis

, 2008
AML1/RUNX1 is a critical transcription factor in hematopoietic cell differentiation and proliferation. From the _AML1_ gene, at least three isoforms, _AML1a_, _AML1b_ and _AML1c_, are produced through alternative splicing.
Zhen Tian, Haiyan Xing, Xiangrong Liu, Dong-er Zhang, Min Wang, Qing Zhang, Qing Rao, Jianxiang Wang, Chunlin Zhou   +8 more
core  

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Not Missing the Notch: Detection Challenges of Juxtamembrane NOTCH1 Variant Detection in T‐Cell Acute Lymphoblastic Leukemia

Journal of Clinical Laboratory Analysis, EarlyView.
ABSTRACT Background Activating mutations in NOTCH1 are frequent in T‐cell acute lymphoblastic leukemia (T‐ALL) and, in the absence of alterations in RAS or PTEN, are associated with favorable prognosis. Besides classical heterodimerization and PEST domain mutations, juxtamembrane internal tandem duplications (JME‐ITDs) represent a third class of ...
Francisco Beas, Stephan Hutter, Ferran Balbastre‐Úbeda, Sandra Novoa‐Jáuregui, Maria Gabarrós‐Subirà, Eulalia Genescà, Petri Pölönen, Torsten Haferlach, Andrés Jerez   +8 more
wiley   +1 more source

Nail Toxicities Associated With Anticancer Therapies in Children

JEADV Clinical Practice, EarlyView.
ABSTRACT Nail toxicities are a frequent yet often underrecognized component of dermatologic adverse events in children receiving anticancer therapies. Both conventional cytotoxic chemotherapy and newer targeted agents can affect the nail matrix, nail bed and periungual tissues, producing a broad spectrum of clinical manifestations that range from ...
Luca Rapparini, Michela Starace
wiley   +1 more source

Genetic alterations in myeloid sarcoma among acute myeloid leukemia patients: insights from 37 cohort studies and a meta-analysis

Frontiers in Oncology
IntroductionVariations in mutation rates among acute myeloid leukemia (AML) patients with myeloid sarcoma (MS) underscore the need for a thorough examination. This meta-analysis was conducted to fill the information gap concerning mutation frequencies in
Suvijak Untaaveesup, Sasinipa Trithiphen, Kamolchanok Kulchutisin, Tarinee Rungjirajittranon, Tarinee Rungjirajittranon, Nattawut Leelakanok, Sujitra Panyoy, Thanapon Kaokunakorn, Weerapat Owattanapanich, Weerapat Owattanapanich   +9 more
doaj   +1 more source