Results 151 to 160 of about 185,548 (298)

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

Allergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller, Julia Hambach, Alessa Zoe Schaffrath, Thomas Eden, Sophia Cichutek, Anna Josephine Gebhardt, Natalie Tode, Ronald Maitschke‐Rajasekharan, Philipp Lewe, Sharon Qi, Susanne Witt, Marie Eggers, Nicola M. Tomas, Friedrich Haag, Friedrich Koch‐Nolte, Boris Fehse, Kristoffer Riecken   +16 more
wiley   +1 more source

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Cytomegalovirus Reactivation During Therapy for Pediatric Acute Lymphoblastic Leukemia. [PDF]

J Med Virol
Melavarige Venkatagiri A, Reddy N, Chandwani R, Shekar N, Perampalli Manjunath S, Abdu Rahiman E, Mukhopadhyay C, Bhat Kalya V.   +7 more
europepmc   +1 more source

A Personalised Vaccination Program Based on Immune Reconstitution in Paediatric Cancer Survivors

Acta Paediatrica, EarlyView.
ABSTRACT Aims Paediatric cancer survivors often experience treatment‐induced immunosuppression, requiring post‐treatment revaccination. However, immune recovery timelines vary, and current revaccination guidelines, largely based on data of varied quality derived from studies on acute‐lymphoblastic‐leukaemia (ALL), may not be applicable across all ...
Menucha Jurkowicz, Raz Somech, Dan Dominissini, Nathan Keller, Efrat Dresner, Michal Paret, Gilad Sherman, Guy Katzenellenbogen, Elina Gelman, Keren Asraf, Ram Doolman, Atar Lev, Amos J. Simon, Helly Vernitsky, Assaf Barg, Hana Golan, Amos Toren, Michal Stein   +17 more
wiley   +1 more source

Dose‐dependent impairment of brain functional and microstructural connectivity during leukaemia chemotherapy

British Journal of Haematology, EarlyView.
Prospective functional MRI brain and neurocognitive assessments were performed serially during intensive chemotherapy for a cohort of adults with newly diagnosed acute myeloid leukaemia to elucidate ‘chemobrain’ language phenomena. At completion of consolidation, significant reductions in functional and microstructural connectivity were observed ...
Ashleigh P. Scott, Ada Lo, Ying Xia, Kate Thompson, Harriet Bodimeade, Amir Fazlollahi, Nicholas Weber, Cameron Curley, Stewart Hunt, Kirk Morris, Caroline McNamara, Nilu Perera, Elango Subramoniapillai, Steven W. Lane, Glen A. Kennedy, Olivier Salvado, Javier Urriola, Katie L. McMahon   +17 more
wiley   +1 more source

The use of venetoclax in the treatment of acute lymphoblastic leukemia-a systematic review. [PDF]

Ther Adv Med Oncol
Kowalczyk A, Zarychta J, Zawitkowska J, Lejman M.   +3 more
europepmc   +1 more source

Invasive yeast infection in paediatric acute lymphoblastic leukaemia: A report from the multi‐international clinical trial AIEOP‐BFM ALL 2009

British Journal of Haematology, EarlyView.
Prospective data of a large randomized multi‐international leukaemia trial revealed an incidence of 1.1% of invasive yeast infections (IYIs) in children with acute lymphoblastic leukaemia. IYIs occurred predominantly during induction chemotherapy, presented as bloodstream infection ± tissue involvement, were due to a variety of yeast and had an ...
Andreas H. Groll, Simone Cesaro, Julia Alten, Andishe Attarbaschi, Draga Barbaric, Daniel Ebrahimi‐Fakhari, Nicole Bodmer, Valentino Conter, Sarah Elitzur, Anja Möricke, Martin Schrappe, Jan Stary, Ester Zapotocka, Martin Zimmermann, Thomas Lehrnbecher   +14 more
wiley   +1 more source

Acute lymphoblastic leukemia: an update on treatment and Brazilian perspective. [PDF]

Front Oncol
Correa BT, Silva GSS, Mendes WJS, Soares LL, Lima JA, Pereira CGS, de Souza JVT, Dos Santos MEF, Aleluia ACM, da Guarda CC, Póvoas RQS, Gonçalves MS, Aleluia MM.   +12 more
europepmc   +1 more source

Haematopoietic stem cell transplantation outcomes for teenage and young adult patients with acute leukaemia: A British Society of Blood and Marrow Transplantation and Cellular Therapy registry study

British Journal of Haematology, EarlyView.
Summary Teenage and young adult (TYA) patients undergoing allogeneic stem cell transplant have distinct psychosocial needs, yet they are poorly represented in research and their outcomes are not well understood. This study uses prospectively collected data from the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT ...
Graham McIlroy, Ben Carpenter, Rachael Hough, Beki James, Caroline Besley, Emma Nicholson, Persis Amrolia, Oana Mirci‐Danicar, Caroline L. Furness, Brenda Gibson, Victoria Potter, Rachel Pearce, Julia Lee, Clementina Abamba, Anna Castleton, Ram Malladi   +15 more
wiley   +1 more source

The combination therapy with venetoclax in therapeutic strategy of acute lymphoblastic leukemia. [PDF]

Discov Oncol
Shamahmood MN, Yousefi MJ, Miri A, Mezginejad F.   +3 more
europepmc   +1 more source