Results 121 to 130 of about 218,068 (352)

Leukocyte density and volume in normal subjects and in patients with acute lymphoblastic leukemia [PDF]

, 1976
Alvin Zipursky, E Bow, RS Seshadri, E J Brown   +3 more
openalex   +1 more source

Targeting the Menin–KMT2A interaction in leukemia: Lessons learned and future directions

International Journal of Cancer, EarlyView.
Abstract Chromosomal rearrangements involving the Mixed Lineage Leukemia gene (MLL1, KMT2A) are defining a genetically distinct subset in about 10% of human acute leukemias. Translocations involving the KMT2A‐locus at chromosome 11q23 are resulting in the formation of a chimeric oncogene, where the N‐terminal part of KMT2A is fused to a variety of ...
Florian Perner, Jayant Y. Gadrey, Scott A. Armstrong, Michael W. M. Kühn   +3 more
wiley   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, EarlyView.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source

A comprehensive consolidation of data on the connection between CDKN2A polymorphisms and the susceptibility to childhood acute lymphoblastic leukemia

Hematology, Transfusion and Cell Therapy
Background: Acute lymphoblastic leukemia is the predominant neoplastic ailment in childhood. Prior research has already established noteworthy connections between CDKN2A polymorphisms and susceptibility to this childhood leukemia, however, substantial ...
Maryam Aghasipour, Fatemeh Asadian, Seyed Alireza Dastgheib, Abolhasan Alijanpour, Ali Masoudi, Maedeh Barahman, Mohammad Golshan-Tafti, Reza Bahrami, Amirmasoud Shiri, Hossein Aarafi, Kazem Aghili, Hossein Neamatzadeh   +11 more
doaj   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

PROGNOSTIC FACTORS IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) [PDF]

, 1977
Stephen E. Sallan, Bruce M. Camitta, Leonard Chess, David G. Nathan   +3 more
openalex   +1 more source

Childhood acute leukemia and type 1 diabetes in children: A nationwide case–control study

International Journal of Cancer, EarlyView.
What's New? The etiology of childhood acute leukemia remains poorly understood. Accumulating evidence suggests a potential link between leukemia and autoimmune diseases. This nationwide, register‐based case–control study investigated the association between childhood acute leukemia and type 1 diabetes in Finland.
Julia Ventelä, Ida Pellikka, Anssi Auvinen, Olli Lohi, Atte Nikkilä   +4 more
wiley   +1 more source

601 IMMUNE STATUS OF CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) IN PROLONGED REMISSION (CR) [PDF]

, 1978
Nancy L. Dunn, Edward C. Russell, Thalachallour Mohanakumar, Nancy B. McWilliams, Harold M. Maurer   +4 more
openalex   +1 more source

Tumor‐infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors

International Journal of Cancer, EarlyView.
Abstract Tumor‐infiltrating B cells (TIBs) exhibit dual roles in the tumor microenvironment (TME) of solid tumors. While they can enhance anti‐tumor immunity through antibody production and immune activation, certain subsets—such as regulatory B cells (Bregs) and immunosuppressive plasma cells—contribute to immune evasion by secreting inhibitory ...
Zhitong Li, Ziyang Shen, Yuxiang Sun, Pengcheng Zhu, Tongyan Liu, Rong Yin   +5 more
wiley   +1 more source

Philadelphia chromosome positive childhood acute lymphoblastic leukemia [PDF]

, 1980
JR Priest, Robison Ll, RW McKenna, LL Lindquist, PI Warkentin, Tucker W. LeBien, WG Woods, JH Kersey, PF Coccia, ME Jr Nesbit   +9 more
openalex   +3 more sources