Results 131 to 140 of about 401,465 (309)

Targeting CDK6 and BCL2 Exploits the MYB Addiction of Ph+ Acute Lymphoblastic Leukemia [PDF]

, 2018
Philadelphia chromosome–positive acute lymphoblastic leukemia (Phþ ALL) is currently treated with BCR-ABL1 tyrosine kinase inhibitors (TKI) in combination with chemotherapy. However, most patients develop resistance to TKI through BCR-ABL1–dependent and –
Addya, Sankar, Calabretta, Bruno, De Dominici, Marco, Ferrari, Anna, Fortina, Paolo, Iacobucci, Ilaria, Mariani, Samanta A., Martinelli, Giovanni, Peterson, Luke F., Porazzi, Patrizia, Rambaldi, Alessandro, Soliera, Angela Rachele, Spinelli, Orietta   +12 more
core   +1 more source

Preclinical efficacy of daratumumab in T-cell acute lymphoblastic leukemia.

Blood, 2018
As a consequence of acquired or intrinsic disease resistance, the prognosis for patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) is dismal. Novel, less toxic drugs are clearly needed.
Karen L. Bride, T. Vincent, Soo-Yeon Im, R. Aplenc, D. Barrett, W. Carroll, R. Carson, Yunfeng Dai, M. Devidas, K. Dunsmore, Tori J. Fuller, Tina Glisovic-Aplenc, T. Horton, S. Hunger, M. Loh, S. Maude, E. Raetz, S. Winter, S. Grupp, M. Hermiston, B. Wood, D. Teachey   +21 more
semanticscholar   +1 more source

Breastfeeding patterns and risk of childhood acute lymphoblastic leukaemia. [PDF]

, 2005
The risk of childhood acute lymphoblastic leukaemia (ALL) was investigated in relation to breastfeeding patterns in the Northern California Childhood Leukaemia Study.
Block, G, Buffler, PA, Ducore, JM, Kwan, ML, Metayer, C, Selvin, S, Wiemels, JL   +6 more
core   +2 more sources

Model-based simulation of maintenance therapy of childhood acute lymphoblastic leukemia [PDF]

arXiv, 2019
Acute lymphoblastic leukemia is the most common malignancy in childhood. Successful treatment requires initial high-intensity chemotherapy, followed by low-intensity oral maintenance therapy with oral 6-mercaptopurine (6MP) and methotrexate (MTX) until 2-3 years after disease onset.
arxiv  

Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. [PDF]

, 2016
High hyperdiploidy (HD), the most common cytogenetic subtype of B-cell acute lymphoblastic leukemia (B-ALL), is largely curable but significant treatment-related morbidity warrants investigating the biology and identifying novel drug targets.
de Smith, Adam J, Endicott, Alyson A, Francis, Stephen S, Hansen, Helen M, Metayer, Catherine, Ojha, Juhi, Sanders, Erica, Smirnov, Ivan, Termuhlen, Amanda M, Walsh, Kyle M, Wiemels, Joseph L   +10 more
core   +1 more source

Genetic Basis of Acute Lymphoblastic Leukemia.

Journal of Clinical Oncology, 2017
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and despite cure rates exceeding 90% in children, it remains an important cause of morbidity and mortality in children and adults.
I. Iacobucci, C. Mullighan
semanticscholar   +1 more source

Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect [PDF]

, 2017
No abstract ...
Baird, Susan F., Forster, Victoria J., Halsey, Christina, Mair, Shona, Skinner, Roderick, van Delft, Frederik W.   +5 more
core   +1 more source

Novel gene targets detected by genomic profiling in a consecutive series of 126 adults with acute lymphoblastic leukemia

Haematologica, 2015
In contrast to acute lymphoblastic leukemia in children, adult cases of this disease are associated with a very poor prognosis. In order to ascertain whether the frequencies and patterns of submicroscopic changes, identifiable with single nucleotide ...
Setareh Safavi, Markus Hansson, Karin Karlsson, Andrea Biloglav, Bertil Johansson, Kajsa Paulsson   +5 more
doaj   +1 more source

Automated Immunophenotyping Assessment for Diagnosing Childhood Acute Leukemia using Set-Transformers [PDF]

arXiv
Acute Leukemia is the most common hematologic malignancy in children and adolescents. A key methodology in the diagnostic evaluation of this malignancy is immunophenotyping based on Multiparameter Flow Cytometry (FCM). However, this approach is manual, and thus time-consuming and subjective. To alleviate this situation, we propose in this paper the FCM-
arxiv  

Ph-like acute lymphoblastic leukemia: a high-risk subtype in adults.

Blood, 2017
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a high-risk subtype of ALL in children. There are conflicting data on the incidence and prognosis of Ph-like ALL in adults.
N. Jain, K. Roberts, E. Jabbour, K. Patel, A. K. Eterovic, Ken Chen, P. Zweidler-McKay, Xinyan Lu, Gloria L. Fawcett, Sa A. Wang, S. Konoplev, R. Harvey, I. Chen, D. Payne-Turner, M. Valentine, D. Thomas, G. Garcia-Manero, F. Ravandi, J. Cortes, S. Kornblau, S. O'brien, S. Pierce, J. Jorgensen, K. Shaw, C. Willman, C. Mullighan, H. Kantarjian, M. Konopleva   +27 more
semanticscholar   +1 more source