Results 181 to 190 of about 223,598 (343)

Expression of the CXCR4 S338X Variant Improves Anti‐Leukemia Efficacy of Anti‐CD19 CAR‐T Cells

Cancer Science, EarlyView.
Under normal conditions, CXCL12 stimulation induces CXCR4 degradation. In contrast, CAR19‐T cells expressing the CXCR4 S338X variant maintain receptor stability and sustain ERK and AKT signaling, which supports T‐cell effector function, migration, and survival. Therefore, the enhanced anti‐leukemic activity is conferred by CXCR4 S338X expression in CAR‐
Yushu Mao, Xiaodan Wang, Chun‐Hui Jin, Zhifeng Wei, Qinghao Ding, Ke‐Ke Zhang, Bo‐Wen Dong, Kai‐Wen Zheng, Yufei Hou, Tao Zhang, Wen‐Jie Zhao, Zheng Hu, Yong‐Guang Yang   +12 more
wiley   +1 more source

Ectopic expression of BEX genes in T-cell acute lymphoblastic leukemia. [PDF]

Blood Adv
Quessada J, Nozais M, Grosjean C, Savey C, Pankaew S, Allelova S, Potier D, Loosveld M, Payet-Bornet D.   +8 more
europepmc   +1 more source

Mapping Dental Care for Children and Adolescents With Rare Diseases: A Brazilian Multicentre Study

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives To describe the landscape of dental care provided by specialised centres for children and adolescents with rare diseases (RDs) in the state of Minas Gerais, southeastern Brazil. Methods A retrospective cross‐sectional study was conducted involving individuals aged 0–18 years with a confirmed diagnosis of a RD who received care at ...
Heloisa Vieira Prado, Rayssa Maria Soalheiro de Souza, Gabriella Guerra Freire Gabrich Fonseca, Kamila Rodrigues Junqueira Carvalho, Anna Vitória Mendes Viana Silva, Iasmin Fonseca Tolentino Mascarenhas, Beatriz Rezende Bergo, Hanna Larissa Barbosa Soares, Bárbara Mendes de Jesus, Layanne Ribeiro Ferreira e Sobral, Kélisson Duarte Reis, Késia Lara dos Santos Marques, Fabiana Sodré de Oliveira, Daniella Reis Barbosa Martelli, José Alcides Almeida de Arruda, Benjamin P. J. Fournier, Denise Vieira Travassos, Soraia Macari, Célia Regina Moreira Lanza, Ana Cristina Borges‐Oliveira, Hercílio Martelli‐Júnior, Tarcília Aparecida Silva   +21 more
wiley   +1 more source

Cerebrovascular complications in pediatric patients with acute lymphoblastic leukemia. [PDF]

Sci Rep
Rocka A, Lesniak M, Majka P, Lipniarska J, Suchcicka M, Lejman M, Wozniak M, Zawitkowska J.   +7 more
europepmc   +1 more source

Oral Microbiome Dynamics in Patients with Acute Lymphoblastic Leukemia and Oral Mucositis. [PDF]

Microorganisms
Sánchez-Becerra AE, Peña-Rodríguez M, Vega-Magaña AN, García-Arellano S, Romo-Rubio HA, Flores-Navarro S, Escobedo-Melendez G, Aranda-Romo S, Zepeda-Nuño JS.   +8 more
europepmc   +1 more source

No benefit of Interfant protocols compared to BFM‐based protocols for infants with acute lymphoblastic leukemia. Results from an institution in Argentina [PDF]

, 2020
Carla Pennella, María A. Deu, Jorge G. Rossi, Edgardo Baialardo, Cristina N. Alonso, Patricia Rubio, Myriam Guitter, C G Sanchez La Rosa, Elizabeth M. Alfaro, Pedro Zubizarreta, Marı́a Sara Felice   +10 more
openalex   +1 more source

Benchmarking the paediatric T‐cell ALL subtype classifier, TALLSorts

British Journal of Haematology, EarlyView.
Ozcan Gulbey, Terena James, Ruth E. Cranston, Dagmara Furmanczyk, Claire Schwab, Anna Lawson, Pam Kearns, Ajay Vora, Juliette Roels, Pieter Van Vlierberghe, Christine J. Harrison, Mark T. Ross, Amir Enshaei, Frederik W. van Delft, Anthony V. Moorman   +14 more
wiley   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Hyper-CVAD in Adults With Acute Lymphoblastic Leukemia in Ecuador: A Multicenter Retrospective Study. [PDF]

Adv Hematol
Sabando B, Quinonez J, Orquera A, Navarrete D, Ramírez J, Sanchez L, Chisesi T, Oliveros J, Pacheco MA, Trujillo MC, Plaza C, Loor Y.   +11 more
europepmc   +1 more source

Dasatinib Produces Lengthy Remissions of Extramedullary Leukemia: A Retrospective Observational Study

European Journal of Haematology, EarlyView.
ABSTRACT Since 2004, patients receiving imatinib with relapse in non‐marrow sites were given dasatinib to preserve control of leukemic marrow. Remissions in CNS and other organs began to be reported and are continuously observed to present. With resistance to one BCR::ABL1 tyrosine kinase inhibitor and sensitivity to a dual BCR::ABL1/SRC inhibitor ...
I. Cunningham, R. A. Fisher, J. Yang, Y. Guo, U. Bommhardt   +4 more
wiley   +1 more source