Results 201 to 210 of about 218,068 (352)

NEAT1 lncRNA overexpression results in short‐term progression and poor treatment outcome in childhood B‐ALL

open access: yesBritish Journal of Haematology, EarlyView.
Childhood acute lymphoblastic leukaemia (chALL) remains the most prevalent malignancy in children and adolescents. Improving risk stratification and providing personalized prognosis and treatment remain major clinical challenges. NEAT1 lncRNA overexpression constitutes a powerful, independent predictor of poor treatment outcomes and disease progression
Marieta Xagorari   +13 more
wiley   +1 more source

A characteristic gene expression profile regulated by ACIN1::NUTM1 fusion in a newly identified infant leukaemic cell line and an ACIN1::NUTM1‐inducible model

open access: yesBritish Journal of Haematology, EarlyView.
An ACIN1::NUTM1‐positive ALL cell line, KOPN32, which was previously established from a relapsed infant‐ALL case, was newly identified. Comparison using 94 BCP‐ALL cell lines, an ACIN1::NUTM1‐inducible ALL model and clinical sample data revealed upregulation of HOXA9, HOXA10, SKIDA1 and BMI1, indicating direct involvement of ACIN1::NUTM1 fusion in the ...
Minori Tamai   +13 more
wiley   +1 more source

Global burden of acute lymphoblastic leukemia following the COVID-19 pandemic. [PDF]

open access: yesAnn Hematol
Fan H   +6 more
europepmc   +1 more source

Early prediction of subsequent peg‐asparaginase inactivation in acute lymphoblastic leukaemia patients—A NOPHO ALL2008 study

open access: yesBritish Journal of Haematology, EarlyView.
Summary Polyethylene glycol (peg)‐asparaginase plays a crucial role in acute lymphoblastic leukaemia (ALL) treatment, yet its associated toxicity often leads to treatment discontinuation, elevating relapse risk. Hypersensitivity with inactivation of asparaginase is common and often associated with severe allergic reactions.
Merete Dam   +18 more
wiley   +1 more source

Combination of targeted pharmacotherapy and immunotherapy with anti-CD19 CAR NK cells in acute lymphoblastic leukemia. [PDF]

open access: yesHemasphere
Kirchhoff H   +10 more
europepmc   +1 more source

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