Results 181 to 190 of about 124,423 (315)

The use of venetoclax in the treatment of acute lymphoblastic leukemia-a systematic review. [PDF]

Ther Adv Med Oncol
Kowalczyk A, Zarychta J, Zawitkowska J, Lejman M.   +3 more
europepmc   +1 more source

Acute lymphoblastic leukemia

, 2011
Práce je věnována akutní lymfoblastické leukémii. Akutní lymfoblastická leukémie je závažné onemocnění krvetvorby, vzniklé nekontrolovaným dělením lymfoblastických buněk.
Suchá, Petra
core  

Blocking SETD2 Enhances the Therapeutic Efficiency of Menin Inhibitor in MLL‐Fusion Leukemia

Cancer Science, EarlyView.
Combined SETD2 and menin inhibitors make synergistic effects against MLL‐fusion leukemia; the combination therapy reduces the expression of target genes through blocking transcription elongation and initiation. ABSTRACT During transcriptional elongation, the histone methyltransferase SETD2 binds to RNA polymerase II and deposits trimethylation marks at
Anpei Li, Yuan Zhang, Ziwei Li, Anhao Liu, Li Zhang, Shubin Gao, Xiao Lin, Xiaoming Liu, Huan Li, Guanghui Jin, Bin Xu   +10 more
wiley   +1 more source

The impact of periconceptional folate on the DNA methylome of acute lymphoblastic leukemia. [PDF]

Leukemia
Nickels EM, Morimoto LM, Kang AY, Metayer C, Wiemels JL.   +4 more
europepmc   +1 more source

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

[Acute lymphoblastic leukemia].

[Rinsho ketsueki] The Japanese journal of clinical hematology, 2014
openaire   +2 more sources

A Rare Case of Cutaneous Extramedullary Hematopoiesis in Chronic Myeloid Leukemia

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Cutaneous extramedullary hematopoiesis (CEH) is a rare manifestation of extramedullary hematopoiesis (EMH), a process typically associated with fetal development or myeloproliferative neoplasms. EMH most commonly involves the spleen, liver, and lymph nodes, with CEH being exceedingly rare in chronic myeloid leukemia (CML).
Bennett Christie‐Nguyen, Hanadi El Achi, Levani Iashvili, Amer Wahed, Brenda Mai, Jacob Armstrong   +5 more
wiley   +1 more source

Central nervous system penetration of imatinib in acute lymphoblastic leukemia: Pharmacokinetic analysis and clinical implications. [PDF]

Cancer Chemother Pharmacol
Rasmussen ASB, Rank CU, Christensen IJ, Weimann A, Hansen K, Thastrup M, Yang T, Lund TM, Wik HS, Vogt H, Norén-Nyström U, Vaitkeviciene G, Albertsen BK, Wehner PS, Als-Nielsen B, Andersen CL, Dalhoff K, Schmiegelow K.   +17 more
europepmc   +1 more source

Superficial Ewing Sarcoma of the Rectum: A Case Report and the Utility of Molecular Diagnostics

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Ewing sarcoma is an undifferentiated small round cell sarcoma that most commonly presents as a malignant bone tumor in pediatric and young adult patients. The diagnosis is typically confirmed by molecular genetic identification of a fusion protein, most commonly involving members of the FET and ETS gene families.
Jessica L. Muldoon, Laura M. Warmke, Ahmed K. Alomari, Rachel P. Kowal   +3 more
wiley   +1 more source

CRLF2 rearrangement and extramedullary disease in B-cell acute lymphoblastic leukemia: a possible link? [PDF]

Blood Adv
Gava F, Yates B, Sun Z, Li G, O'Koren C, Adhikari B, Lugar S, Shalabi H, Mattison R, Turkbey EB, Yuan CM, Paietta E, Wang HW, Mullighan C, Silbert SK, Litzow M, Shah NN.   +16 more
europepmc   +1 more source