Results 311 to 320 of about 218,068 (352)
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Acute lymphoblastic leukemia in the elderly
European Journal of Haematology, 1990We report our findings in 18 patients with acute lymphoblastic leukemia (ALL) aged 60 years or older. A preleukemic syndrome was observed in 2 patients. Compared to younger adults with ALL, L3 morphology was unexpectedly frequent (4/16) T‐ALL was not observed. Other criteria of poor prognosis (high white blood cell count, CNS involvement, organomegaly,
Delannoy, André +7 more
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Asparaginase in Acute Lymphoblastic Leukemia
Clinical Lymphoma Myeloma and Leukemia, 2014Cure rates in pediatric acute lymphoblastic leukemia have significantly improved over the past decades. Now, almost 90% of children will survive the disease. The cure rates in adolescents, young adults, and adults have not kept pace with the improvements in younger patients, even though almost an equal proportion of adult patients achieve complete ...
Michael Rytting, Jitesh D. Kawedia
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Pharmacogenomics in acute lymphoblastic leukemia
Best Practice & Research Clinical Haematology, 2017Pharmacogenomics is a fast-growing field of personalized medicine using a patient's genomic profile to determine drug disposition or response to drug therapy, in order to develop safer and more effective pharmacotherapy. Childhood acute lymphoblastic leukemia (ALL), being the most common malignancy in childhood, which is treated with uniform and ...
Shawn H.R. Lee, Jun J. Yang
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Preleukemia in Acute Lymphoblastic Leukemia
Acta Haematologica, 1981A patient who presented with preleukemia evolving into acute lymphoblastic leukemia is described. The preleukemic phase was characterized by a positive acidified serum lysis test (Ham test).
I. Ariel +2 more
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Neonatal Acute Lymphoblastic Leukemia
Pediatric Emergency Care, 2020Abstract Acute lymphoblastic leukemia (ALL) in a neonate can have a similar clinical appearance to other serious pathology and should be considered in the ill-appearing infant. We present the case of a 24-hour-old male infant born to a mother with limited prenatal care who was brought to the pediatric emergency department with a rash and ...
Andrew L. Juergens +4 more
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Pharmacogenetics of acute lymphoblastic leukemia
Current Opinion in Hematology, 2004The outcome in children with acute lymphoblastic leukemia has improved significantly over the past four decades. Current therapy results in event-free survival exceeding 80% for most patients. The development of risk-adapted therapy based on characteristics of the child (age), leukemia (leukocyte count, acquired genetic characteristics) and early ...
Stella M. Davies, Parinda A. Mehta
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2007
Acute lymphoblastic leukemias (ALLs) are a group of hematological neoplasias defined by cytomorphology, cytochemistry, immunological markers, and more recently, molecular markers. The prognosis of ALL has much improved in the last 30 yr, especially in the age group between 2 and 10 yr, where most patients can be cured by chemotherapy.
Vishwas S. Sakhalkar, Reinhold Munker
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Acute lymphoblastic leukemias (ALLs) are a group of hematological neoplasias defined by cytomorphology, cytochemistry, immunological markers, and more recently, molecular markers. The prognosis of ALL has much improved in the last 30 yr, especially in the age group between 2 and 10 yr, where most patients can be cured by chemotherapy.
Vishwas S. Sakhalkar, Reinhold Munker
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Mitoxantrone in acute lymphoblastic leukemia
Cancer Treatment Reviews, 1983Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethylamino]]9,10 anthracenedione dihydrochloride, CL 232,215 (NSC 301739) is a synthetic aminoanthraquinone which binds to DNA (2, 17), and was designed to reduce or eliminate the cardiotoxicity seen with the structurally related anthracycline antibiotics (1).
Takao Ohnuma +4 more
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Treatment of Acute Lymphoblastic Leukemia
New England Journal of Medicine, 2006Although the overall cure rate of acute lymphoblastic leukemia (ALL) in children is about 80 percent, affected adults fare less well. This review considers recent advances in the treatment of ALL, emphasizing issues that need to be addressed if treatment outcome is to improve further.
William E. Evans, Ching-Hon Pui
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Acute lymphoblastic leukemia in adults
Current Treatment Options in Oncology, 2000The therapy of acute lymphoblastic leukemia (ALL) in adults has built on the remarkable success achieved in the treatment of this disease in children. However, older age and other adverse risk factors seen more commonly in adults than in children have lessened the success of the treatment of ALL in comparison with what has been achieved in children ...
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