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Acute lymphoblastic leukemia in the elderly
European Journal of Haematology, 1990We report our findings in 18 patients with acute lymphoblastic leukemia (ALL) aged 60 years or older. A preleukemic syndrome was observed in 2 patients. Compared to younger adults with ALL, L3 morphology was unexpectedly frequent (4/16) T‐ALL was not observed. Other criteria of poor prognosis (high white blood cell count, CNS involvement, organomegaly,
Delannoy, André +7 more
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Chemoimmunotherapy in acute lymphoblastic leukemia
Blood Reviews, 2012ALL blast cells express a variety of specific antigens e.g. CD19, CD20, CD22, CD33, and CD52, which serve as targets for Monoclonal Antibodies (MoAbs). So far, the most experience is available for anti-CD20 (rituximab), which has been combined with chemotherapy for treatment of mature B-ALL/Burkitt's lymphoma.
Dieter, Hoelzer, Nicola, Gökbuget
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Immunophenotyping of Acute Lymphoblastic Leukemia
2019Immunophenotyping by flow cytometry is an important component in the diagnostic evaluation of patients with acute lymphoblastic leukemia. This technique further permits the detection of minimal residual disease after therapy, a robust prognostic factor that may guide individualized treatment.
Joseph A, DiGiuseppe +1 more
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Acute Lymphoblastic Leukemia: Background
2003Acute lymphoblastic leukemia is a fascinating disease for the cytogeneticist, as so many cases have a clone detectable by cytogenetics or FISH, and because identifying the abnormalities provides such useful information to the clinician. However, it is also a frustrating disease, as it has technical challenges such as a marked tendency for the sample to
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Acute Lymphoblastic Leukemia of Childhood
Hematology/Oncology Clinics of North America, 1987Over the last 20 years, the rate of long-term disease-free survival of childhood acute lymphoblastic leukemia increased from less than 1 to 60 per cent. Strategies for disease control include (1) intensive multiagent induction to rapidly decrease the tumor burden and minimize the chance of emergence of a resistant population of cells, (2) restoration ...
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Hypercalcemia in acute lymphoblastic leukemia
Leukemia Research, 1994J F, Seymour, H M, Kantarjian
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Extensive Remodeling of the Immune Microenvironment in B Cell Acute Lymphoblastic Leukemia
Cancer Cell, 2020Matthew T Witkowski +2 more
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Infection-related complications during treatment for childhood acute lymphoblastic leukemia
Annals of Oncology, 2017Randall T Hayden +2 more
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Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia
Cancer Cell, 2018Michelle L Churchman +2 more
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