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Pediatric Acute Lymphoblastic Leukemia
Hematology, 2003AbstractThe outcome for children with acute lymphoblastic leukemia (ALL) has improved dramatically with current therapy resulting in an event free survival exceeding 75% for most patients. However significant challenges remain including developing better methods to predict which patients can be cured with less toxic treatment and which ones will ...
William L, Carroll +8 more
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Granular Acute Lymphoblastic Leukemia
American Journal of Clinical Pathology, 1983Granules in blasts are most typical of acute myeloblastic leukemia. However, there have been scattered reports of patients with acute lymphoblastic leukemia (ALL) that have lymphoblasts with azurophilic cytoplasmic granules. These reports do not describe immunologic markers or cytogenetics.
P, Stein +5 more
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Pharmacogenomics in acute lymphoblastic leukemia
Best Practice & Research Clinical Haematology, 2017Pharmacogenomics is a fast-growing field of personalized medicine using a patient's genomic profile to determine drug disposition or response to drug therapy, in order to develop safer and more effective pharmacotherapy. Childhood acute lymphoblastic leukemia (ALL), being the most common malignancy in childhood, which is treated with uniform and ...
Shawn H R, Lee, Jun J, Yang
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Mitoxantrone in acute lymphoblastic leukemia
Cancer Treatment Reviews, 1983Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethylamino]]9,10 anthracenedione dihydrochloride, CL 232,215 (NSC 301739) is a synthetic aminoanthraquinone which binds to DNA (2, 17), and was designed to reduce or eliminate the cardiotoxicity seen with the structurally related anthracycline antibiotics (1).
P A, Paciucci +4 more
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Asparaginase in Acute Lymphoblastic Leukemia
Clinical Lymphoma Myeloma and Leukemia, 2014Cure rates in pediatric acute lymphoblastic leukemia have significantly improved over the past decades. Now, almost 90% of children will survive the disease. The cure rates in adolescents, young adults, and adults have not kept pace with the improvements in younger patients, even though almost an equal proportion of adult patients achieve complete ...
Jitesh D, Kawedia, Michael E, Rytting
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Childhood Acute Lymphoblastic Leukemia
Pediatric Annals, 1988Acute lymphoblastic leukemia accounts for 80% of leukemia in children. The exact cause is unknown, but some genetic, immunologic, viral, and environmental factors have been implicated. Symptoms at the time of diagnosis frequently include fever, bleeding, fatigue, and irritability. Initial white blood cell count and patient age at diagnosis are the most
C A, Diamond, K K, Matthay
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Acute Lymphoblastic Leukemia in Childhood
Pediatric Clinics of North America, 1985This article reviews those factors that have been responsible for progress in the past, describes current biologic and therapeutic approaches to ALL, and discusses those unresolved treatment issues that pose the major challenge for the future.
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Childhood acute lymphoblastic leukemia
Reviews in Clinical and Experimental Hematology, 2002As cure rates in childhood acute lymphoblastic leukemia reach 80%, emphasis is increasingly placed on the accurate identification of drug‐resistant cases, the elucidation of the mechanisms involved in drug resistance and the development of new therapeutic strategies targeted toward the pivotal molecular lesions.
Ching-Hon, Pui +3 more
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Acute lymphoblastic leukemia in adults
Current Treatment Options in Oncology, 2000The therapy of acute lymphoblastic leukemia (ALL) in adults has built on the remarkable success achieved in the treatment of this disease in children. However, older age and other adverse risk factors seen more commonly in adults than in children have lessened the success of the treatment of ALL in comparison with what has been achieved in children ...
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Acute lymphoblastic leukemia: Treatment
Cancer, 1978Over the past thirty years, major progress has been achieved in the treatment of ALL. Many of the concepts, definitions, and principles of chemotherapy have and continue to be derived from studies in ALL. Major and continuing progress is ongoing for the various categories of treatment; that is, remission induction, treatment at sites of high risk for ...
E, Frei, S E, Sallan
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