Results 271 to 280 of about 124,423 (315)
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Leukemia cutis in acute lymphoblastic leukemia
Journal of the American Academy of Dermatology, 1994separating normal epidermis from a diffuse dermal infiltrate of lymphoid blast cells with round and regular nuclei, inconspicuous nucleoli, and scanty, moderately basophilic cytoplasm. Immunophenotype analysis revealed strong positivity for CD 10.The patient wastreated with methotrexate, teniposide, cytosine arabinoside, and local irradiation, and a ...
J F, de Lacerda +5 more
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Pediatric Clinics of North America, 1980
The improved outlook in childhood leukemia can be attributed to more accurate diagnosis, better supportive care, the use of drug combinations to achieve and maintain remission, and prophylactic therapy to prevent central nervous system leukemia. With the best treatment available today, 65 to 70 per cent of children are in complete continuous remission ...
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The improved outlook in childhood leukemia can be attributed to more accurate diagnosis, better supportive care, the use of drug combinations to achieve and maintain remission, and prophylactic therapy to prevent central nervous system leukemia. With the best treatment available today, 65 to 70 per cent of children are in complete continuous remission ...
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Treatment of Acute Lymphoblastic Leukemia
Annual Review of Medicine, 1972The treatment of acute lymphoblastic leukemia in the last decade can be said to have reached a revolutionary phase. Prior to that time, the disease was considered to be uniformly fatal and treatment was being given essen tially for palliation. These concepts have changed and now the well-informed investigator is employing acute leukemia protocols ...
J H, Burchenal, M D, Dowling, C T, Tan
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2007
Acute lymphoblastic leukemia (ALL) comprises a heterogeneous group of disorders which originate from various important genetic lesions in B and T progenitor cells, including mutations that lead to stage-specific developmental arrest and those that impart the capacity for unlimited self-renewal, resulting in clonal expansion of immature progenitor cells
Biondi A., Scrideli C. A., Cazzaniga G.
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Acute lymphoblastic leukemia (ALL) comprises a heterogeneous group of disorders which originate from various important genetic lesions in B and T progenitor cells, including mutations that lead to stage-specific developmental arrest and those that impart the capacity for unlimited self-renewal, resulting in clonal expansion of immature progenitor cells
Biondi A., Scrideli C. A., Cazzaniga G.
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Hematology/Oncology Clinics of North America, 2009
Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms ...
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Acute lymphoblastic leukemia and lymphoblastic lymphoma constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms ...
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Preleukemia in Acute Lymphoblastic Leukemia
Acta Haematologica, 2009A patient who presented with preleukemia evolving into acute lymphoblastic leukemia is described. The preleukemic phase was characterized by a positive acidified serum lysis test (Ham test). The connection between an erythromyeloproliferative disorder and a lymphoproliferative disorder is discussed.
I, Ariel +2 more
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Pathobiology of acute lymphoblastic leukemia
Seminars in Diagnostic Pathology, 2011In the present review, the authors described the pathobiological features of B- and T-ALL, which appear to be quite heterogeneous with regard to molecular pathogenesis. The last edition of the World Health Organization Classification considered this aspect by defining many entities based on genetic findings.
PAOLINI, STEFANIA +5 more
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Pharmacogenetics of acute lymphoblastic leukemia
Current Opinion in Hematology, 2004The outcome in children with acute lymphoblastic leukemia has improved significantly over the past four decades. Current therapy results in event-free survival exceeding 80% for most patients. The development of risk-adapted therapy based on characteristics of the child (age), leukemia (leukocyte count, acquired genetic characteristics) and early ...
Parinda A, Mehta, Stella M, Davies
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Best Practice & Research Clinical Haematology, 2001
Precursor B-ALL (BCP-ALL) is associated with a good outcome in children. Cytogenetics is one of the gold standards for risk stratification for treatment that has contributed to improved survival. Although in T-ALL genetic analysis has not been used to guide therapy, it has contributed significantly to the understanding of the biology.
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Precursor B-ALL (BCP-ALL) is associated with a good outcome in children. Cytogenetics is one of the gold standards for risk stratification for treatment that has contributed to improved survival. Although in T-ALL genetic analysis has not been used to guide therapy, it has contributed significantly to the understanding of the biology.
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Acute Lymphoblastic Leukemia in Childhood
Pediatric Clinics of North America, 1988This article reviews the current biologic understanding of acute lymphoblastic leukemia and describes current approaches to treatment. It discusses the areas likely to be the focus of future research for this disease, including therapy for high-risk patients, understanding the reasons for treatment failure, and identification of new antileukemic agents.
D G, Poplack, G, Reaman
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