Results 51 to 60 of about 401,465 (309)

Dynamic clonal progression in xenografts of acute lymphoblastic leukemia with intrachromosomal amplification of chromosome 21 [PDF]

, 2018
Intrachromosomal amplification of chromosome 21 is a heterogeneous chromosomal rearrangement occurring in 2% of childhood precursor B-cell acute lymphoblastic leukemia.
Bashton, Matthew, Blair, Helen H., Buechler, Lars, Carey, Peter, Cheng, Joanna, Clayton, Jake, Halsey, Christina, Hanna, Rebecca, Harrison, Christine J., Hawking, Zoe, Heidenreich, Olaf, Hollern, Shaun, Jones, Lisa, Marr, Helen, Moorman, Anthony V., Russell, Lisa J., Ryan, Sarra L., Schwab, Claire J., Sinclair, Paul B.   +18 more
core   +3 more sources

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

Haematologica, 2011
The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases.
Vera Grossmann, Wolfgang Kern, Stefan Harbich, Tamara Alpermann, Sabine Jeromin, Susanne Schnittger, Claudia Haferlach, Torsten Haferlach, Alexander Kohlmann   +8 more
doaj   +1 more source

Explainable AI in Diagnosing and Anticipating Leukemia Using Transfer Learning Method [PDF]

, 2023
This research paper focuses on Acute Lymphoblastic Leukemia (ALL), a form of blood cancer prevalent in children and teenagers, characterized by the rapid proliferation of immature white blood cells (WBCs). These atypical cells can overwhelm healthy cells, leading to severe health consequences.
arxiv   +1 more source

Three-dimensional chromatin landscapes in T cell acute lymphoblastic leukemia

Nature Genetics, 2020
Differences in three-dimensional (3D) chromatin architecture can influence the integrity of topologically associating domains (TADs) and rewire specific enhancer–promoter interactions, impacting gene expression and leading to human disease.
A. Kloetgen, Palaniraja Thandapani, P. Ntziachristos, Yohana Ghebrechristos, Sofia Nomikou, C. Lazaris, Xufeng Chen, Hai-yang Hu, Sofia Bakogianni, Jingjing Wang, Yi Fu, F. Boccalatte, Hua Zhong, E. Paietta, Thomas Trimarchi, Yixing Zhu, P. Van Vlierberghe, G. Inghirami, T. Lionnet, I. Aifantis, A. Tsirigos   +20 more
semanticscholar   +1 more source

T-ALL and thymocytes : a message of noncoding RNAs [PDF]

, 2017
In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs.
Durinck, Kaat, Speleman, Franki, Taghon, Tom, Van Vlierberghe, Pieter, Wallaert, Annelynn   +4 more
core   +3 more sources

A case of therapy-related acute lymphoblastic leukemia following the treatment of acute myeloid leukemia

Leukemia Research Reports, 2022
Therapy-related acute lymphoblastic leukemia represents a distinct entity associated with inferior survival compared with de novo acute lymphoblastic leukemia.
Sufana Shikdar, Yuan Ying, Mohamad Khawandanah   +2 more
doaj  

Automated Detection of Acute Promyelocytic Leukemia in Blood Films and Bone Marrow Aspirates with Annotation-free Deep Learning [PDF]

arXiv, 2022
While optical microscopy inspection of blood films and bone marrow aspirates by a hematologist is a crucial step in establishing diagnosis of acute leukemia, especially in low-resource settings where other diagnostic modalities might not be available, the task remains time-consuming and prone to human inconsistencies.
arxiv  

Rapid identification of BCR/ABL1-like acute lymphoblastic leukaemia patients using a predictive statistical model based on quantitative real time-polymerase chain reaction: clinical, prognostic and therapeutic implications. [PDF]

, 2018
BCR/ABL1-like acute lymphoblastic leukaemia (ALL) is a subgroup of B-lineage acute lymphoblastic leukaemia that occurs within cases without recurrent molecular rearrangements.
Apicella, V, Bareja, R, Chiaretti, S, Di Giacomo, F, Elemento, O, Fedullo, Al, Foà, R, Gianfelici, V, Grammatico, S, Guarini, A, Inghirami, G, Lauretti, A, Li, Ls, Martelli, Mp, Messina, M, Peragine, N, Piciocchi, A, Salek, C, Vignetti, M, Vitale, A, Weinstock, Dm   +20 more
core   +1 more source

A case report of secondary B-cell acute lymphoblastic leukemia treated with a combination of FLT3 inhibitor and decitabine

Frontiers in Oncology
Secondary acute lymphoblastic leukemia (s-ALL) refers to acute lymphoblastic leukemia that occurs after a previous malignant tumor, including therapy-related acute lymphoblastic leukemia (t-ALL) and prior malignant tumor acute lymphoblastic leukemia (pm ...
Mengci Hu, Wenzhe Li, Pan Li, Jie Tan, Ya Wang, Ya Wang   +5 more
doaj   +1 more source

Correlation of Serum Lipoproteins with the Activity of Acute Lymphoblastic Leukaemia

مجله كليه طب الكندي, 2019
Background: the activity of acute lymphoblastic leukemia had been observed to correlate with levels of serum lipoproteins Objective: to evaluate the correlation of serum levels of different types of lipoproteins with activity of the disease in ...
Azher Sebieh Al-Zubaidy
doaj   +1 more source