Results 31 to 40 of about 185,548 (298)

B-Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma [PDF]

American Journal of Clinical Pathology, 2015
This session of the 2013 Society of Hematopathology/European Association for Haematopathology Workshop was dedicated to B-acute lymphoblastic leukemia (B-ALL)/lymphoblastic lymphoma (LBL) with recurrent translocations and not otherwise specified.In this review, we summarize the cases discussed during the workshop, review the pertinent and most recent ...
Sanam, Loghavi, Jeffery L, Kutok, Jeffrey L, Jorgensen   +2 more
openaire   +2 more sources

CREBBP knockdown enhances RAS/RAF/MEK/ERK signaling in Ras pathway mutated acute lymphoblastic leukemia but does not modulate chemotherapeutic response

Haematologica, 2017
Relapsed acute lymphoblastic leukemia is the most common cause of cancer-related mortality in young people and new therapeutic strategies are needed to improve outcome.
Zach A. Dixon, Lindsay Nicholson, Martin Zeppetzauer, Elizabeth Matheson, Paul Sinclair, Christine J. Harrison, Julie A.E. Irving   +6 more
doaj   +1 more source

Poor Prognosis Biomolecular Factors Are Highly Frequent in Childhood Acute Leukemias From Oaxaca, Mexico

Technology in Cancer Research & Treatment, 2020
Objective: To investigate the cellular and molecular epidemiology of acute leukemias in vulnerable populations of children and adolescents in Oaxaca de Juarez, Mexico.
Gerardo Juárez-Avendaño MSc, Nuria Citlalli Luna-Silva MD, Euler Chargoy-Vivaldo MD, Laura Alicia Juárez-Martínez MD, Mayra Noemí Martínez-Rangel BS, Noemí Zárate-Ortiz BS, Edith Martínez-Valencia BS, Briceida López-Martínez MD, Rosana Pelayo PhD, Juan Carlos Balandrán PhD   +9 more
doaj   +1 more source

Acute Lymphoblastic Leukemia Presenting with Right Atrial Thrombosis and Massive Pulmonary Embolism: A Case Report

Middle East Journal of Cancer, 2020
Thrombosis is a rare complication of acute lymphoblastic leukemia usually occurring following chemotherapy. The most common reported site is intracranial thrombosis.
Amirataollah Hiradfar, Shamsi Ghaffari, Soroush Mostafavi   +2 more
doaj   +1 more source

Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria

Haematologica, 2010
Background Mixed phenotype acute leukemia (MPAL) represents a diagnostic and therapeutic dilemma. The European Group for the Immunological Classification of Leukemias (EGIL) scoring system unambiguously defines MPAL expressing aberrant lineage markers ...
Ester Mejstrikova, Jana Volejnikova, Eva Fronkova, Katerina Zdrahalova, Tomas Kalina, Jaroslav Sterba, Yahia Jabali, Vladimir Mihal, Bohumir Blazek, Zdena Cerna, Daniela Prochazkova, Jiri Hak, Zuzana Zemanova, Marie Jarosova, Alexandra Oltova, Petr Sedlacek, Jiri Schwarz, Jan Zuna, Jan Trka, Jan Stary, Ondrej Hrusak   +20 more
doaj   +1 more source

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia [PDF]

, 2013
Key Points First report demonstrating in vivo elimination of multiple LIC populations from childhood ALL cases using animal models. In vivo models of leukemia are essential for drug evaluation studies.
Blair, Allison, Cox, Charlotte V, Diamanti, Paraskevi, Moppett, John P   +3 more
core   +2 more sources

Pediatric acute lymphoblastic leukemia

Haematologica, 2020
The last decade has witnessed great advances in our understanding of the genetic and biological basis of childhood acute lymphoblastic leukemia (ALL), the development of experimental models to probe mechanisms and evaluate new therapies, and the development of more efficacious treatment stratification.
Hiroto Inaba, Charles G. Mullighan
openaire   +4 more sources

Immature MEF2C-dysregulated T-cell leukemia patients have an early T-cell precursor acute lymphoblastic leukemia gene signature and typically have non-rearranged T-cell receptors

Haematologica, 2014
Three distinct immature T-cell acute lymphoblastic leukemia entities have been described including cases that express an early T-cell precursor immunophenotype or expression profile, immature MEF2C-dysregulated T-cell acute lymphoblastic leukemia cluster
Linda Zuurbier, Alejandro Gutierrez, Charles G. Mullighan, Kirsten Canté-Barrett, A. Olivier Gevaert, Johan de Rooi, Yunlei Li, Willem K. Smits, Jessica G.C.A.M. Buijs-Gladdines, Edwin Sonneveld, A. Thomas Look, Martin Horstmann, Rob Pieters, Jules P.P. Meijerink   +13 more
doaj   +1 more source

Cerebral sinuses thrombosis prior to the diagnosis of acute lymphoblastic leukemia in a child: A case report

SAGE Open Medical Case Reports, 2022
Acute lymphoblastic leukemia is the most common malignancy in children. In children, venous thromboembolism is relatively common. In most cases, venous thromboembolism manifests in patients who are diagnosed with acute lymphoblastic leukemia.
Laila M Sherief, Marwa Zakaria, Basma K Soliman, Naglaa M Kamal, Sultan A Alharthi, Sara AS Abosabie, Mahmoud Abdelazeem   +6 more
doaj   +1 more source

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

Haematologica, 2011
The runt-related transcription factor 1, RUNX1, is crucial in the development of myeloid and lymphoid cell lineages and has been reported to be mutated in myeloid malignancies in approximately 30% of cases.
Vera Grossmann, Wolfgang Kern, Stefan Harbich, Tamara Alpermann, Sabine Jeromin, Susanne Schnittger, Claudia Haferlach, Torsten Haferlach, Alexander Kohlmann   +8 more
doaj   +1 more source