Results 21 to 30 of about 1,680,023 (310)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Relapsed Acute Lymphoblastic Leukemia

Indian Journal of Pediatrics, 2023
AbstractOutcomes for children with acute lymphoblastic leukemia (ALL) have improved worldwide to >85%. For those who relapse, outcomes have remained static at ~50% making relapsed acute lymphoblastic leukemia one of the leading causes of death in childhood cancers.
Sidhu, Jasmeet, Gogoi, Manash Pratim, Krishnan, Shekhar, Saha, Vaskar; id_orcid 0000-0002-2916-9649   +3 more
openaire   +4 more sources

Association of ARID5B gene variants with acute lymphoblastic leukemia in Yemeni children

Tumor Biology, 2017
Studies have shown an association between ARID5B gene polymorphisms and childhood acute lymphoblastic leukemia. However, the association between ARID5B variants and acute lymphoblastic leukemia among the Arab population still needs to be studied. The aim
Boshra Al-absi, Suzita M Noor, Riyadh Saif-Ali, Sameer D Salem, Radwan H Ahmed, Muhammad FM Razif, Sekaran Muniandy   +6 more
doaj   +1 more source

In vitro validation of γ-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia

Haematologica, 2008
Background Activating NOTCH1 mutations are common in T-cell acute lymphoblastic leukemia. Inhibition of NOTCH1 signaling with γ-secretase inhibitors causes cell cycle block, but only after treatment for several days.
Kim De Keersmaecker, Idoya Lahortiga, Nicole Mentens, Cedric Folens, Leander Van Neste, Sofie Bekaert, Peter Vandenberghe, Maria D. Odero, Peter Marynen, Jan Cools   +9 more
doaj   +1 more source

Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia

Haematologica, 2010
Background Differences in survival have been reported between pediatric and adult acute lymphoblastic leukemia. The inferior prognosis in adult acute lymphoblastic leukemia is not fully understood but could be attributed, in part, to differences in ...
Ryoko Okamoto, Seishi Ogawa, Daniel Nowak, Norihiko Kawamata, Tadayuki Akagi, Motohiro Kato, Masashi Sanada, Tamara Weiss, Claudia Haferlach, Martin Dugas, Christian Ruckert, Torsten Haferlach, H. Phillip Koeffler   +12 more
doaj   +1 more source

Preserved cellular immunity in smoldering acute leukemia [PDF]

, 1976
"Smoldering acute leukemia", a variant of acute myelogenous leukemia, has been recognized with frequent incidence in recent years. This is chracterized by benign clinical course, poor physical findings, leukopenia and mild anemia in the ...
Hironobu Toki, Toki, Hironobu
core   +1 more source

Acute lymphoblastic leukemia and gingival enlargement – a case report

, 2021
Gingival enlargement is caused by various factors such as inflammation, medications and malignant diseases. Acute leukemic enlargement is commonly seen in children.
Neetha J. Shetty, Sameep Shetty, Raj, Akanksha, Akanksha Raj, Gayathri, S., Shetty, Neetha J., S. Gayathri, Shetty, Sameep   +7 more
core   +1 more source

The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system

Haematologica, 2017
Central nervous system infiltration and relapse are poorly understood in childhood acute lymphoblastic leukemia. We examined the role of zeta-chain-associated protein kinase 70 in preclinical models of central nervous system leukemia and performed ...
Ameera Alsadeq, Henning Fedders, Christian Vokuhl, Nele M. Belau, Martin Zimmermann, Tim Wirbelauer, Steffi Spielberg, Michaela Vossen-Gajcy, Gunnar Cario, Martin Schrappe, Denis M. Schewe   +10 more
doaj   +1 more source

WILMS' TUMOR GENE 1 (WT1) EXPRESSION IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA [PDF]

Zagazig University Medical Journal, 2014
Aim &Objectives: Wilms ٰ ٰ tumor 1 (Wt1) gene is over expressed in majorty of acute leukemia.The aim of this study is to evaluate(WT1) gene expression in children with acute lymphoblastic leukemia and to find out the relationship between it and other
Mohamed Badr, Tamer Hassan, Asmaa Esh, Wesam Mokhtar   +3 more
doaj   +1 more source

Evaluation of Plasma Level of Anticoagulant Proteins (Protein C, S and Anti thrombin III) in Patients with Acute Lymphoblastic Leukemia [PDF]

Al-Azhar International Medical Journal, 2023
Background: Acute lymphoblastic leukemia (ALL) is related to many coagulation abnormalities like hemorrhage and thrombosis.Objectives: research was to assess role of plasma activity levels of anticoagulant proteins( Protein C, Protein S & Anti ...
ibrahim Hazman, Osama bakheet, Mohamed Khedr, Yousri Zoheri   +3 more
doaj   +1 more source