Results 281 to 290 of about 87,634 (337)
Allogeneic stem cell transplantation for patients with chronic myeloid leukemia and acute lymphocytic leukemia after Bcr-Abl kinase mutation–related imatinib failure
, 2006 Elias Jabbour, Jorge E. Cortés, Hagop M. Kantarjian, Sergio Giralt, Dan Jones, Roy B. Jones, Francis J. Giles, Börje S. Andersson, Richard E. Champlin, M. Lima +9 moreopenalex +1 more sourceAutologous haematopoietic stem cell transplantation for multiple sclerosis in the UK: A 20‐year retrospective analysis of activity and haematological outcomes from the British Society of Blood and Marrow Transplantation and Cellular Therapy (BSBMTCT)
British Journal of Haematology, EarlyView.We report the UK experience of autologous haematopoietic stem cell transplantation (AHSCT) for multiple sclerosis (MS) in 364 patients. In our observational study, transplant‐related mortality was 1.4%, Epstein–Barr virus reactivation occurred in 75.9%, while disability progression‐free survival was 83.5% at 2 years post‐AHSCT and 62.4% at 5 years.Majid Kazmi, Paolo A. Muraro, Varun Mehra, Ian Gabriel, Eleonora De Matteis, Gavin Brittain, Alice Mariottini, Richard Nicholas, Eli Silber, Julia Lee, Rachel Pearce, Ruth Paul, Maria Pia Sormani, Alessio Signori, Victoria Potter, Eduardo Olavarria, Ram Malladi, Basil Sharrack, John A. Snowden +18 morewiley +1 more sourceDifferent clearance of KITD816V mutation and tryptase levels after haematopoietic cell transplantation in patients with systemic mastocytosis with associated haematological neoplasm
British Journal of Haematology, EarlyView.Summary
The patterns of tryptase normalization, KITD816V clearance and establishment of donor cell chimerism were analysed in 13 patients with systemic mastocytosis and associated haematological neoplasm (AHN) after haematopoietic cell transplantation (HCT).Christian Niederwieser, Anita Badbaran, Radwan Massoud, Nico Gagelmann, Ameya Kunte, Evgeny Klyuchnikov, Niloufar Seyedi, Silke Heidenreich, Ina Rudolph, Gaby Zeck, Catherina Lück, Dietlinde Janson, Christine Wolschke, Francis Ayuk, Nicolaus Kröger +14 morewiley +1 more sourceA prior status of graft‐versus‐host disease affects donor lymphocyte infusion outcomes in patients with relapsed haematological malignancies after allogeneic stem cell transplantation
British Journal of Haematology, EarlyView.Summary
Optimizing the effectiveness of donor lymphocyte infusion (DLI) for relapse after allogeneic stem cell transplantation (alloHSCT) has been challenging. We investigated whether the benefits of achieving full donor chimerism (FDC) and developing graft‐versus‐host disease (GVHD) after DLI are affected by a history of GVHD before DLI.Claudia Mae Velasco, Yoshitaka Inoue, Joseph Cioccio, Kevin Rakszawski, Natthapol Songdej, Myles Nickolich, Hong Zheng, Seema Naik, Christopher Ehmann, Joseph Mierski, Brooke Silar, Caitlin Vajdic, Robert Greiner, Valerie Brown, Shin Mineishi, Hiroko Shike, Kentaro Minagawa +16 morewiley +1 more sourceThe anti‐CD47 antibody magrolimab with obinutuzumab and venetoclax in relapsed or refractory indolent B‐cell lymphomas
British Journal of Haematology, EarlyView.Follicular lymphoma (FL), marginal zone lymphoma (MZL), chronic lymphocytic leukaemia (CLL) and mantle cell lymphoma (MCL) are characterized by a continuous incidence of relapse and increasing resistance to therapy. Novel immunotherapy approaches are needed.Rahul Lakhotia, Christopher Melani, Stefania Pittaluga, Max J. Gordon, James D. Phelan, Jagan R. Muppidi, Atekelt Tadese, Sarah Evans, Elaine S. Jaffe, Louis M. Staudt, Wyndham H. Wilson, Mark Roschewski +11 morewiley +1 more sourceOutcomes of children with haematological malignancies given second haploidentical haematopoietic stem cell transplantation with either TCRαβ/CD19 depletion or post‐transplant cyclophosphamide
British Journal of Haematology, EarlyView.Summary
Human leukocyte antigen (HLA)‐haploidentical haematopoietic cell transplantation (haplo‐HCT) is a suitable salvage strategy in children with haematological malignancies experiencing either relapse or graft failure (GF) after the first HCT.Riccardo Masetti, Davide Leardini, Francesca Gottardi, Francesco Baccelli, Giorgio Antonio Maria Ottaviano, Francesca Vendemini, Francesco Saglio, Filomena Pierri, Mattia Algeri, Francesca Del Bufalo, Pietro Merli, Arcangelo Prete, Simone Cesaro, Marek Ussowicz, Maura Faraci, Marco Zecca, Franca Fagioli, Adriana Balduzzi, Jean‐Hugues Dalle, Franco Locatelli, Daria Pagliara +20 morewiley +1 more sourceCD123‐targeting immunotherapeutic approaches in acute myeloid leukaemia
British Journal of Haematology, EarlyView.Summary
Treatment of relapsed or refractory acute myeloid leukaemia (AML) has remained a significant challenge, with limited available targeted immunotherapies. CD123, or the interleukin‐3 (IL‐3) receptor, has long been known as a potential target expressed on AML blasts, and a range of different approaches to targeting CD123 have been trialled with ...Alexandra Dreyzin, Noa G. Holtzman, Challice L. Bonifant +2 morewiley +1 more sourceThe importance of systemic inflammatory response measurements as pretransplant risk factors for outcome after allogeneic haematopoietic cell transplantation
British Journal of Haematology, EarlyView.In oncological patients SIR measures like the mGPS have great impact on prognosis at starting therapy. We recorded at admission for allo‐HCT the mGPS in 2201 patients: score 0 CRP/sALB normal; score 1 CRP >10mg/dl; score 2 CRP >10mg/dl + sALB <35g/L. Multivariate analysis revealed a significant impact with a low GPS score for OS: mGPS 1 vs.Hartmut Bertz, Jörg Sahlmann, Donald C. McMillan, Claudia Wehr, Jesus Duque‐Afonso, Kristina Maas‐Bauer, Ralph Wäsch, Julia Nikolaychuk, Christine Greil, Jann Arends, Jürgen Finke, Robert Zeiser +11 morewiley +1 more sourceImpact of the addition of antithymocyte globulin to post‐transplantation cyclophosphamide in haploidentical transplantation with peripheral blood compared to post‐transplantation cyclophosphamide alone: A retrospective study on behalf of the Cellular Therapy and Immunobiology Working Party of the European Society for Blood and Marrow Transplantation
British Journal of Haematology, EarlyView.Summary
In the setting of haploidentical haematopoietic cell transplantation (HCT), post‐transplant cyclophosphamide (PTCy) has dramatically reduced the incidence of graft‐versus‐host disease (GVHD) and non‐relapse mortality. To further reduce GVHD incidence, the addition of antithymocyte globulin (ATG) to PTCy was evaluated in retrospective and non ...Antoine Capes, Jarl E. Mooyaart, Didier Blaise, Stefania Bramanti, Mi Kwon, Mohamad Mohty, Patrice Chevallier, Jan Vydra, Péter Reményi, Edouard Forcade, Lucía López Corral, Maija Itälä‐Remes, Ali Bazarbachi, Enrico Derenzini, Jorinde D. Hoogenboom, Jürgen Kuball, Giorgia Battipaglia, Florent Malard, Annalisa Ruggeri +18 morewiley +1 more source