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Total Therapy of Acute Lymphocytic Leukemia
JAMA: The Journal of the American Medical Association, 1972In 1962, the total therapy approach to acute lymphocytic leukemia was developed at St. Jude Children's Research Hospital. Briefly, it consists of rapid and efficient induction of complete remission with prednisone and vincristine in order to minimize early attrition, cranial or craniospinal irradiation during the first month of complete remission to ...
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PATHOLOGIC DIAGNOSIS OF ACUTE LYMPHOCYTIC LEUKEMIA
Hematology/Oncology Clinics of North America, 2000With present knowledge, the optimal management of individual patients with acute leukemia requires that every case be studied by morphology, cytochemistry, cytogenetic, immunologic and molecular techniques. An algorithm for diagnostic evaluation and classification of ALL is provided in Fig. 11.
R, Lai +2 more
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Infectious Mononucleosis in Acute Lymphocytic Leukemia
JAMA: The Journal of the American Medical Association, 1965An 18-year-old high-school student was found to have lymphoblastic leukemia at the age of 16 years. Remission was obtained with weekly doses of 2 mg/sq m of body surface of vincristine sulfate and daily doses of 40 mg/ sq m of prednisone. Maintenance treatment with intramuscular administration of methotrexate, 30 mg/sq m twice weekly, was initiated ...
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Acute transformation of chronic lymphocytic leukemia
Medical and Pediatric Oncology, 1984AbstractA patient with chronic lymphocytic leukemia had typical cell morphology and a characteristic clinical course for 7 years. He then developed progressive disease with a rapidly rising WBC which proved resistant to chemotherapy. The cells resembled lymphoblasts.
A D, Jacobs, R W, Schroff, R P, Gale
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CYTOGENETICS IN ADULT ACUTE LYMPHOCYTIC LEUKEMIA
Hematology/Oncology Clinics of North America, 2000The outcome of adult ALL patients has improved over the years, with an increase in median DFS from 0.9 years before 1988 to 1.7 years alter 1988. There is still ample room for improvement. Cytogenetic analysis at diagnosis can assist in developing risk-adapted therapeutic strategies and in devising new treatment modalities by an understanding of the ...
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Emerging drugs for acute lymphocytic leukemia
Expert Opinion on Emerging Drugs, 2013Acute lymphoblastic leukemia (ALL) is typically treated with complex multi-agent chemotherapy regimens over a prolonged time period. Long-term outcomes depend on the age of the patient and the biological characteristics of the leukemic cells. While pediatric patients achieve cure more often than adults, therapy can continue to be improved for all ...
Michael S, Mathisen +2 more
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Treatment of Acute Lymphocytic Leukemia in Uganda
Acta Haematologica, 2009The hematologic remission rate of 17 black Ugandan children with acute lymphocytic leukemia treated with prednisone and vincristine was 41%. There was no correlation of the remission rate with any clinical or laboratory finding at the time of diagnosis.
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Cytomegaloviremia in children with acute lymphocytic leukemia
The Journal of Pediatrics, 1975Leukocyte and urine cultures were done at monthly intervals in 36 children with acute lymphocytic leukemia known to be excreting cytomegalovirus in their or saliva in order to determine the relationship of viremia to clinical cytomegalic inclusion disease. Eleven of 36 (30.5%) patients had viremia.
F, Cox, W T, Hughes
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Cancer After Acute Lymphocytic Leukemia
Archives of Pediatrics & Adolescent Medicine, 1981Curing children of cancer is wonderful, but it is not without other risks, as we are beginning to learn. In 1964 only 2% of children with acute lymphocytic leukemia (ALL) survived five years. 1 Now, if treated with optimal therapy, 50% of these children survive five years or longer.
P A, Gilman, R W, Miller
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Apoptosis and Acute Lymphocytic Leukemia in Children
Annals of the New York Academy of Sciences, 1997We examined in vivo spontaneous and prednisolone-induced apoptosis in peripheral blood samples of 23 children with ALL by flow cytometric and morphologic methods. There was no significant spontaneous apoptosis before the therapy. Six hours after prednisolone therapy, increased apoptosis was found in 19 of 23 cases.
Schuler, Dezső, Szende, Béla
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