Results 241 to 250 of about 2,092,286 (303)

TIM‐3 Functions as an Activator of NK Cells in GBM and Can Be Upregulated by Torin‐1: Implications for Exogenous NK Cell Transplantation

open access: yesImmunology, EarlyView.
Unlike generalized mTOR inhibitors, Torin‐1 uniquely drives compensatory upregulation of TIM‐3 on human NK cells, shielding them from immunosuppression while concurrently inhibiting glioblastoma (GBM) growth. Selecting or preconditioning ex vivo NK cell products for high TIM‐3 expression can offer a combination strategy for adoptive cell therapy in GBM.
Yuning Liu   +11 more
wiley   +1 more source

Management of Non‐Plaque‐Induced Gingival Conditions: A Systematic Review—Part 2: Inflammatory and Immune Conditions; Neoplasms; and Gingival Pigmentation

open access: yesJournal of Clinical Periodontology, EarlyView.
ABSTRACT Aims This systematic review assesses current evidence on the management of non‐plaque (dental biofilm)‐induced gingival diseases and conditions (NPIGDs), including (i) inflammatory and immune conditions, (ii) neoplasms and (iii) gingival pigmentations.
Maria Clotilde Carra   +5 more
wiley   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

open access: yesJournal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed   +6 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

open access: yesJournal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima   +3 more
wiley   +1 more source

Oral Lichenoid Lesions in Patients With Dyskeratosis Congenita: A Retrospective Case Series

open access: yesOral Diseases, EarlyView.
ABSTRACT Background Dyskeratosis congenita (DKC) is a rare inherited multisystem disorder primarily affecting the mucocutaneous and hematopoietic systems. Classically, it presents with the ectodermal triad of reticulate skin pigmentation, nail dystrophy, and oral leukoplakia.
Yehuda Zadik   +9 more
wiley   +1 more source

Acute lymphocytic leukemia in children

Cancer, 1975
An overview is presented of the improvements in the prognosis of acute lymphocytic leukemia due to combined modality therapy. With the best available regimens, approximately 50% of these children have remained leukemia-free for 5 years or more. Because of these results, there is growing concern for the quality of survival and for the side effects of ...
J V, Simone   +3 more
openaire   +2 more sources

Lymphocyte Surface Markers in Acute Lymphocytic Leukemia

American Journal of Clinical Pathology, 1974
Lymphoblasts from 17 cases of acute lymphocytic leukemia were studied for the presence of lymphocytic surface markers. In one case, lymphoblasts displayed an increase in nonimmune rosette formation. In two cases, an increase in cells manifesting surface immunoglobulins was observed.
F R, Davey, A J, Gottlieb
openaire   +2 more sources

Acute lymphocytic leukemia

Hématologie, 2014
Les leucemies aigues lymphoblastiques (LAL) sont des proliferations malignes de precurseurs lymphoides anormaux bloques a un stade precoce de differenciation. Les LAL de l’enfant et de l’adulte different par leurs caracteristiques et leurs pronostics. L’identification de nouveaux mecanismes d’oncogenese et l’evaluation de la reponse par quantification ...
Diane Lara, Martin Gauthier
openaire   +1 more source

Chromosomes in acute lymphocytic leukemia

Cancer Genetics and Cytogenetics, 1987
Results of chromosome analysis in acute lymphocytic leukemia are reviewed. Emphasis is placed on so-called specific translocations and their association with cytology, immunology, and prognosis. Data presently available suggest that chromosomes in acute lymphocytic leukemia are not only an important, independent prognostic factor, but also contribute ...
openaire   +2 more sources

Relapsed acute lymphocytic leukemia

Current Oncology Reports, 2008
Introduction: Acute lymphocytic leukemia (ALL) is the most common cancer found in children. It accounts for 25% of all childhood cancers in patients younger than 21 years old in the United States [1]. About 2400 children, adolescents, and young adults develop ALL in the United States each year.
openaire   +2 more sources

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