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Immunophenotypic analysis of acute lymphocytic leukemia

Hematology/Oncology Clinics of North America, 2002
Acute lymphoblastic leukemia (ALL) is one of the most common hematologic malignancies. Flow cytometry is an integral part of ALL diagnosis and also provides significant patient prognostic information. This article is a practical review of the basic principles of the flow cytometric evaluation of acute leukemias, the interpretation of flow cytometric ...
Roger S, Riley   +4 more
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Treatment of Childhood Acute Lymphocytic Leukemia

The Journal of Pediatrics, 1970
Thank you for the honor of sharing in this memorial to Frederick Stohlman. The work I will report today represents the efforts of many physicians and scientists who have tried to understand and control childhood leukemia.
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Dermatoglyphics and Acute Lymphocytic Leukemia in Children

Journal of Pediatric Oncology Nursing, 1991
Cellular features of acute lymphocytic leukemia (ALL) in children suggest that it originates in abnormal embryogenesis. Because palmar flexion creases develop in the embryo at the same time as the blood-forming cells, and because both arise from mesodermal tissue, insults to the embryo that may lead to leukemic changes in the blood-forming cells may ...
J, Edelstein, M, Amylon, J A, Walsh
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Giant mitochondria in acute lymphocytic leukemia

Experimental and Molecular Pathology, 1987
Giant mitochondria were observed in 2 cases among 28 cases of ALL by electron microscopy. The cristae of the giant mitochondria in the leukemic cells were irregularly arranged, decreased in number, and formed concentric circles. Several morphological abnormalities were also observed in the normal mitochondria.
M, Eguchi   +6 more
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PROGENY OF SURVIVORS OF ACUTE LYMPHOCYTIC LEUKEMIA

Acta Paediatrica, 1979
Abstract. Eight successful pregnancies and one spontaneous abortion have been observed in 5 women belonging to a group of 212 Nordic children who had their antileukemic therapy discontinued before January 1, 1978. Furthermore a young leukemic man was the father of a healthy child after 4 years of intensive cytostatic therapy.
P J, Moe   +5 more
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Angiogenesis in acute and chronic lymphocytic leukemia

Leukemia Research, 2004
The bone marrow microenvironment plays a crucial role in leukemogenesis. Recent studies suggest that its vascularity changes significantly during this process and that angiogenic factors are of major importance in leukemia. This review summarizes the literature concerning the relationship between angiogenesis and the progression of acute and chronic ...
MOLICA S   +4 more
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Acute Lymphocytic Leukemia

1996
Abstract Acute lymphocytic leukemia is a neoplastic proliferation of lymphoid progenitor cells in the blood and bone marrow. Acute lymphocytic leukemia is the predominant form of leukemia in childhood and also occurs in adults. Patients with acute lymphocytic leukemia typically present with symptoms of anemia, thrombocytopenia, or ...
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Lymphocyte glutathione levels in acute leukemia

Clinica Chimica Acta, 1999
The current interest in the clinical significance of the glutathione estimation in leukemia is due to its widespread effect on the cell constituent and cell function of the hematopoietic system. It helps and protects the cells against free radicals and reactive oxygen products.
V, Singh Ghalaut   +3 more
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Acute lymphocytic leukemia cytochemistry and ultrastructure

Blut Zeitschrift für die Gesamte Blutforschung, 1974
Cytochemical methods allow the distinction of a peculiar-PAS and β-glucuronidase positive-type of acute leukemia, which, according to previous authors, is termed acute lymphocytic leukemia (ALL). The cytochemical pattern suggests poor differentiation, which is confirmed by electron microscopic investigations.
F, Schmalzl   +3 more
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HL-A Antigens and Acute Lymphocytic Leukemia

American Journal of Clinical Pathology, 1974
Twenty-four children with acute lymphocytic leukemia were compared with unmatched, unrelated normal controls for 20 HL-A specificities. No association between HL-A specificities and susceptibility to acute leukemia could be established. However, additional cytotoxic reactions were observed in the lymphocytes of three of six patients when malignant ...
F R, Davey, J B, Henry, A J, Gottlieb
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