Results 61 to 70 of about 47,614 (291)

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

Deconstructing Pediatric Acute Lymphocytic Leukemia

MedEdPORTAL, 2012
This is an online module which is aimed at teaching medical students key concepts about Pediatric Acute Lymphocytic Leukemia. At the end of this module, the learner will be able to: (1) Recognize different presenting symptoms of leukemia in pediatric ...
David Gass, Harris Burstin, Sabrina Lee, So-Young Oh, Linda Tewksbury   +4 more
doaj   +1 more source

Acute lymphocytic leukemia masquerading as acute retinal necrosis

American Journal of Ophthalmology Case Reports, 2020
To report a case of B-cell acute lymphocytic leukemia (ALL) relapse presenting as acute retinal necrosis.An 11-year old boy with history of B-cell ALL undergoing maintenance therapy presented with a three-month history of intermittent blurry vision and pain in the right eye when a routine lumbar puncture indicated an elevated lymphoblast-predominant ...
Kaylene L. Carter, Muhammad Hassan, Diana V. Do, Quan Dong Nguyen   +3 more
openaire   +4 more sources

Suppressing t(4;11) Acute Leukemia by Lipopolymer Nanoparticle Delivery of siRNA Targeting KMT2A::AFF1 with Enhanced Extrahepatic Delivery

Advanced Healthcare Materials, EarlyView.
This study introduces a new lipopolymer nanoparticle (LPNP) system that efficiently delivers siRNA to leukemia cells. The LPNPs silence the leukemia fusion gene KMT2A::AFF1, induce apoptosis, and decrease leukemia burden in mice. These results demonstrate the potential of LPNPs as a targeted siRNA therapy for acute lymphoblastic leukemia.
Mohammad Nasrullah, Remant KC, Amarnath Praphakar Rajendran, Saba Abbasi Dezfouli, Cezary Kucharski, Xiaoyan Jiang, Spencer B. Gibson, Joseph Brandwein, Olaf Heidenreich, Hasan Uludağ   +9 more
wiley   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Sweet Syndrome in a Patient with Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Curious Lymphocyte/Neutrophil Fluctuations

Turkish Journal of Hematology, 2013
Sweet syndrome, also referred to as acute febrile neutrophilic dermatosis, is characterized by tender, red inflammatory nodules or papules that occur in association with infection, malignancy, connective tissue disease, or following exposure to certain ...
Çiğdem Usul Afşar, Semra Paydaş, Meral Günaldı, Berna Bozkurt Duman, Vehbi Erçolak, Suzan Zorludemir, Arbil Açıkalın   +6 more
doaj   +1 more source

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Advanced Therapeutics, EarlyView.
This review covers the mechanical forces experienced by immune cells through cell–cell and cell–extracellular matrix interactions and how these forces influence their receptors and functions. These relationships between forces and cellular functions can be exploited using engineering techniques to modify the physical properties of materials for novel ...
Yu‐Chang Chen, Nghi M. Tran, Kyle H. Vining   +2 more
wiley   +1 more source

MALIGNANT HEMATOLOGICAL DISORDERS ON BONE MARROW ASPIRATION : AN EXPERIENCE FROM TERTIARY CARE HOSPITALS

Gomal Journal of Medical Sciences, 2018
Background: Bone marrow aspiration is a diagnostic test for various hematological malignancies. Present study was designed to determine the frequency of malignant Hematological disorders on bone marrow aspiration.
Hamzullah Khan, Riaz Uddin Ghori, Fakhre Alam Khattak, Toqeeer Ahmad   +3 more
doaj  

Nutritional assessment and serum zinc and copper concentration in leukemic children

São Paulo Medical Journal, 1999
CONTEXT: Malnutrition in childhood cancer is commonly a serious problem. Changes in blood zinc and copper have also been found in malignant diseases. OBJECTIVE: To describe the protein-energy nutritional status and serum zinc and copper of children with
Ursula Rohr Sgarbieri, Mauro Fisberg, Luis Gonzaga Tone   +2 more
doaj   +1 more source