Results 51 to 60 of about 1,703,142 (259)
Epigenetic Activation of SOX11 in Lymphoid Neoplasms by Histone Modifications [PDF]
, 2011 Recent studies have shown aberrant expression of SOX11 in various types of aggressive B-cell neoplasms. To elucidate the molecular mechanisms leading to such deregulation, we performed a comprehensive SOX11 gene expression and epigenetic study in stem ...Amador Virginia, Ott, G. (German), Royo Cristina, Palomero, J. (Jara), Agirre, Xabier, Salaverria Frigola, Itziar, Manel Esteller, Román-Gómez, José, Esteller, Manel, Balazs Balint, Andreas Rosenwald, Xargay-Torrent Silvia, Martín-Guerrero Idoia, Rosenwald, Andreas, Campo, E. (Elías), Pedro Jares, Royo Moreno, Cristina, Royo, Cristina, Hernández, Luis, Vegliante Maria Carmela, Rosenwald Andreas, Siebert, Reiner, Siebert Reiner, Martin-Guerrero, I. (Idoia), Balint, B. (Balazs), Jares, P. (Pedro), Calasanz María José, Prosper Felipe, Esteller Manel, Palomero Jara, Reiner Siebert, Agirre Xabier, Calasanz, María José, Bea Silvia, Roman-Gomez José, Vegliante, M.C. (Maria Carmela), Campo Elias, Silvia Bea, Lujambio, A. (Amaya), Beà Bobet, Sílvia M., Jose Calasanz, Maria, Roman-Gomez, J. (José), Vegliante, Maria Carmela, Maria Carmela Vegliante, María José Calasanz, Balint Balazs, Luis Hernandez, Enjuanes Anna, Enjuanes, A. (Anna), Felipe Prosper, Balint, Balazs, Martin-Subero, J.I. (Jose Ignacio), Salaverria, Itziar, Richter, Julia, Martín Guerrero, Idoia, Ott, German, Jares Gerboles, Pedro, Xargay-Torrent, S. (Silvia), Martín-Subero José I., Amaia Lujambio, Cristina Royo, José Roman-Gomez, José I Martín-Subero, Maria Carmela Vegliante, Martin-Guerrero, Idoia, Anna Enjuanes, Carmela Vegliante, Maria, Salaverria-Lete, I. (Itziar), Richter, J. (Julia), Esteller, M. (Manel), Martin-Subero, Jose I., Richter Julia, Bea, Silvia, Rosenwald, A. (Andreas), Xargay-Torrent, Silvia, Jares Pedro, Royo, C. (Cristina), Prosper-Cardoso, F. (Felipe), Campo Güerri, Elias, José I. Martín-Subero, Campo, Elias, Idoia Martín-Guerrero, Ott German, Calasanz-Abinzano, M.J. (Maria Jose), Lujambio, Amaia, Hernandez, L. (Luis), Palomero, Jara, Silvia Xargay-Torrent, Jares, Pedro, Hernandez Luis, Lujambio Amaia, Virginia Amador, German Ott, Jara Palomero, Bea, S. (Silvia), Elias Campo, Amador, V. (Virginia), Xargay i Torrent, Sílvia, Julia Richter, Salaverria Itziar, Siebert, R. (Reiner), Amador, Virginia, Enjuanes, Anna, Aguirre-Ena, X. (Xabier), Itziar Salaverria, Prosper, Felipe, Xabier Agirre, Esteller, Manel, 1968- +107 morecore +1 more sourceGenetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models
Advanced Science, EarlyView.Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna +22 morewiley +1 more sourceFirst case of B ALL with KMT2A-MAML2 rearrangement: a case report
BMC Cancer, 2017 Background A large number of chromosomal translocations of the human KMT2A gene, better known as the MLL gene, have so far been characterized. Genetic rearrangements involving KMT2A gene are frequently involved in lymphoid, myeloid and mixed lineage ...Estelle Menu, Nathalie Beaufils, Fabrice Usseglio, Estelle Balducci, Marina Lafage Pochitaloff, Regis Costello, Jean Gabert +6 moredoaj +1 more sourceRelationship between FLT3 mutation status, biologic characteristics, and response to targeted therapy in acute promyelocytic leukemia [PDF]
, 2005 The prognostic significance of FLT3 mutations in acute promyelocytic leukemia (APL) is not firmly established and is of particular interest given the opportunities for targeted therapies using FLT3 inhibitors.Gilkes, Amanda F., Ellen Solomon, Linch, D C, Gale, Rosmary E., Burnett, Alan Kenneth, Gale, RE, David C. Linch, Pizzey, AR, Elizabeth Nugent, Keith Wheatley, Grimwade, D., Grimwade, D, Solomon, E, Pizzey, A R, Solomon, Ellen, Kenneth I. Mills, Swirsky, D, Pizzey, A.R., Burnett, A K, Alan K. Burnett, Hills, Robert Kerrin, Swirsky, David, Kottaridis, Panagiotis D., Grimwade, David, Linch, David C., ?, ?, Hills, R., David Swirsky, Gale, R E, Gilkes, A F, Kottaridis, PD, Solomon, E., Robert Hills, Linch, D.C., Arnold R. Pizzey, Nugent, E., Rosemary E. Gale, Mills, KI, Nugent, Elizabeth, Gale, R.E., Swirsky, D., Hills, Robert, Hills, R, NCRI Adult Leukaemia Working Party, David Grimwade, Kottaridis, P D, Linch, DC, Wheatley, K., Amanda F. Gilkes, Wheatley, Keith, Gilkes, AF, Nugent, E, Panagiotis D. Kottaridis, Mills, K I, Mills, Ken; id_orcid, Kottaridis, P.D., Burnett, AK, Burnett, A.K., Mills, Kenneth I., Gilkes, A.F., Wheatley, K, Pizzey, Arnold R. +61 morecore +1 more sourceRepurposing a Small Molecule Plant Hormone as a Tunable ON‐Switch for CAR‐T Cell Immunotherapy
Advanced Science, EarlyView.By engineering a receptor system integrating the plant auxin receptor AFB1 with its co‐receptor IAA7, we enable ligand‐dependent interactions triggered by the plant hormone auxins. This design allows rapid, reversible, and dose‐dependent T cell activation, resulting in potent cytotoxicity against B‐cell lymphoma in vitro and in vivo.Hongxiang Zeng, Lei Zheng, Rongkun Tao, Sirui Zheng, Yanke Zhong, Yongxia Niu, Peng Zhang, Xiang Ma, Chen Yang, Min Zhang, Fuyu Duan, Jing Yang, Xuan Wei, Xiang Zhou, Zhenbiao Yang, Zhaoxi Sun, Qizhou Lian +16 morewiley +1 more sourceFarnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells
Haematologica, 2014 Although farnesyltransferase inhibitors have shown promising activity in relapsed lymphoma and sporadic activity in acute myelogenous leukemia, their mechanism of cytotoxicity is incompletely understood, making development of predictive biomarkers ...Husheng Ding, Jennifer S. McDonald, Seongseok Yun, Paula A. Schneider, Kevin L. Peterson, Karen S. Flatten, David A. Loegering, Ann L. Oberg, Shaun M. Riska, Shengbing Huang, Frank A. Sinicrope, Alex A. Adjei, Judith E. Karp, X. Wei Meng, Scott H. Kaufmann +14 moredoaj +1 more sourceKinase Inhibition in Relapsed/Refractory Leukemia and Lymphoma Settings: Recent Prospects into Clinical Investigations
Pharmaceutics, 2021 Cancer is still a major barrier to life expectancy increase worldwide, and hematologic neoplasms represent a relevant percentage of cancer incidence rates.Caio Bezerra Machado, Flávia Melo Cunha de Pinho Pessoa, Emerson Lucena da Silva, Laudreísa da Costa Pantoja, Rodrigo Monteiro Ribeiro, Manoel Odorico de Moraes Filho, Maria Elisabete Amaral de Moraes, Raquel Carvalho Montenegro, Rommel Mário Rodriguez Burbano, André Salim Khayat, Caroline Aquino Moreira-Nunes +10 moredoaj +1 more sourceLeukemia autopsies in Japan [PDF]
, 1964 For the purpose to know whether the annual increase of leukemia incidence in Japan is due to some leukemogenic factors or due to the increased detection
rate, the authors made some statistical survey of autopsy cases in which the
diagnosis is reliable ...Seno, Satimaru, Asakura, Hikaru, Katano, Takashi, Hamada, Hisao, Toyama, Yuki, Shibata, Takashi, Hayashi, Kenji, Nakatsuka, Ayako, Matsuoka, Kenichi, Monden, Hisashi, Seki, Shuji +10 morecore +1 more source
