Results 171 to 180 of about 1,921,670 (307)

Prognostic Significance of Secondary-Type Mutations in NPM1-Mutated Acute Myeloid Leukemia. [PDF]

Cancer Med
Yang K, Luo H, Xiang B, Dai Y, Gong Y, Huang J, Li J, Jia Y, Guo Y, Zheng Y, Ma H.   +10 more
europepmc   +1 more source

A practical difference from the normal approach to evaluate natural killer (NK) cells and NK cell neoplasms by flow cytometry

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Natural killer (NK) cell neoplasms span indolent to highly aggressive entities, and flow cytometric immunophenotyping is central to their detection and classification. However, distinguishing reactive from neoplastic NK cell expansions can be challenging because NK cells lack somatically recombined antigen receptors, and reactive states may ...
Aaron J. Wilk, Afshin Shameli, Erik Ames, Jonathan R. Fromm, Bartosz Grzywacz, Min Shi, Sindhu Cherian, Jean Oak   +7 more
wiley   +1 more source

Synthetic lethality in TP53-mutant acute myeloid leukemia. [PDF]

Blood Adv
Patel SA.
europepmc   +1 more source

Old data, new tricks: Comprehensive computational analysis of 10 years of multi‐center EuroFlow acute myeloid leukemia diagnostic immunophenotypic data

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Acute myeloid leukemia (AML) is characterized by high genotypic and immunophenotypic heterogeneity. We collected an extensive dataset containing 5366 flow cytometry files from 885 AML patients, stained with the EuroFlow acute leukemia orientation tube (ALOT) and AML/MDS panel, acquired in a standardized way at eight centers over a period of 10 
Sarah Bonte, Rosan Olsman, Sofie Van Gassen, Sergio Matarraz, Neus Villamor, Stefan Nierkens, Paula Fernandez, Elaine Sobral da Costa, Carmen‐Mariana Aanei, Alberto Orfao, Jacques J. M. van Dongen, Yvan Saeys, Mattias Hofmans, Vincent H. J. van der Velden   +13 more
wiley   +1 more source

Melatonin potentiates the antineoplastic effects of venetoclax in acute myeloid leukemia cells. [PDF]

Hematol Transfus Cell Ther
Vahedian V, Lima K, de Almeida BO, Cavaglieri RC, Machado-Neto JA, Rego EM.   +5 more
europepmc   +1 more source

Subset‐specific and tissue‐specific expression of NK‐cell markers and killer immunoglobulin‐like receptors: Implications for NK‐cell clonality assessment

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate immunophenotypic evaluation of natural killer (NK)‐cell neoplasms is challenging because NK‐cells lack somatically rearranged antigen receptors, are comprised of phenotypically distinct subsets, and exhibit tissue‐specific subset distribution. We developed a flow cytometry (FC) panel for NK‐cell immunophenotypic analysis and clonality
Valerie Woodings, Orrin Koepke, Jason E. Love, Alireza Torabi, Lianqun Qiu, Jonathan R. Fromm, Sindhu Cherian, Afshin Shameli   +7 more
wiley   +1 more source

Clinical applications of CD34+ progenitor cell immunophenotyping in myelodysplastic neoplasms—The CytHem SMD French network experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Myelodysplastic neoplasms (MDS) are clonal hematopoietic disorders characterized by ineffective hematopoiesis, peripheral cytopenias, and a risk of progression to acute myeloid leukemia. As the disease originates in hematopoietic stem and progenitor cells (HSPCs), flow cytometry (FCM) has emerged as a key approach to interrogate the bone ...
Nicolas Chapuis, Anne‐Catherine Lhoumeau, Stéphanie Mathis, Michel Ticchioni, Valérie Bardet, the French Working Group CytHem‐SMD   +5 more
wiley   +1 more source

Consolidation Therapy Based on Mutation Clearance in Acute Myeloid Leukemia. [PDF]

NEJM Evid
Jacoby MA, Spencer DH, Gao F, Uy GL, Burton T, Heath SE, Du F, O'Laughlin M, Fulton RS, Miller CA, Duncavage EJ, Schroeder MA, Ghobadi A, Pusic I, Stockerl-Goldstein KE, Kahl BS, Cashen AF, Christopher MJ, Singh N, Vij R, Crees ZD, Wartman LD, Day RB, Fehniger TA, Oetjen KA, Patel DA, Kim MY, Slade MJ, Ferraro F, Walter MJ, Abboud CN, Abboud R, Link DC, Al-Mansour ZA, Cogle CR, Huselton EJ, DiPersio JF, Westervelt P, Ley TJ.   +38 more
europepmc   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source

Menin Inhibitors in Acute Myeloid Leukemia: From Molecular Rationale to Clinical Practice. [PDF]

J Pers Med
Alati C, Molica M, Pitea M, Porto G, Marafioti V, Giordano L, De Fazio L, Rossi M, Martino M.   +8 more
europepmc   +1 more source