Results 251 to 260 of about 361,051 (341)

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

cellMCD Effectively Discovers Drug Resistance and Sensitivity Genes for Acute Myeloid Leukemia. [PDF]

Genes (Basel)
Obodo D, Nguyen NHK, Cao X, Parcha PK, Vulpe CD, Lamba JK, Pounds SB.   +6 more
europepmc   +1 more source

A Novel Prognostic Risk‐Scoring Model Based on RAS Gene‐Associated Cluster in Pediatric Acute Myeloid Leukemia [PDF]

Chen Luo, Yilimuguli Abudukeremu, Mingliang Rao, Dun‐hua Zhou, Jian‐Pei Fang, Yang Li, Lu‐Hong Xu   +6 more
openalex   +1 more source

Leukemia in Older Adults: Global, National, and Regional Disease Burden Patterns During 1990–2019 and Forecasted Trends to 2030

Medicine Advances, EarlyView.
After analyzing the burden of leukemia in the elderly aged 60–89 years from 1990 to 2019 using the Global Burden of Disease database, we found that although the burden of chronic myeloid leukemia has decreased over the past 30 years, the burden of other types of leukemia has continued to increase to varying degrees.
Jing Wei, Qijian Feng, Ziyuan Lu
wiley   +1 more source

Characterizing <i>KMT2A</i> Rearrangement in Acute Myeloid Leukemia: A Comprehensive Genomic Study. [PDF]

Cancers (Basel)
Batayneh O, Moein M, Naji NS, Patel A, Mandava AR, Goodman A, Ross JS, Ho C, Marcus C, Zhou Z, Kupakuwana-Suk G, Gentile T, Ghimire KB.   +12 more
europepmc   +1 more source

Incidence of JAK2V617F Mutation in Patients with Acute Myeloid Leukemia

, 2015
HALIME OZCAM
openalex   +1 more source

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source

Assessment <b></b>of Serum P53 Protein Level in Adult Patients with Acute Myeloid Leukemia in Correlation with Response to Treatment

Laith A. Jebur, Haithem Ahmed Al-Rubaie
openalex   +2 more sources

Rib Ewing Sarcomas in Children and Young Adults: A Large National Retrospective Series

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Purpose Ewing sarcoma (ES) is the most prevalent malignant thoracic tumor in childhood and young adults. This study reports the outcome of a national cohort treated in an international prospective trial for a localized rib ES, with a long follow‐up.
Audrey Claren, Alexandre Beige, Magali Morelle, Jérôme Doyen, Cyril Lervat, Luc Ollivier, Cécile Vérité, Perrine Marec‐Bérard, Maria Jolnerovski, Anne Ducassou, Valentine Martin, Line Claude, French Multidisciplinary Working Group on Bone Primary Tumours (GROUPOS), GSF (French Sarcoma Group), GETO (Bone Tumour Study Group) and SFCE (French Society for the Fight against Childhood and Adolescent Cancer and Leukaemia)   +14 more
wiley   +1 more source

Aggressive Disease and Poor Clinical Outcome in CEBPα-Mutated Acute Myeloid Leukemia Patient. [PDF]

Clin Case Rep
Alshammari AA, AlSabbagh MO, Alshehri HM, AlSwayyed AF, Alseraye FM, Peer-Zada AA.   +5 more
europepmc   +1 more source