Results 21 to 30 of about 1,795,367 (304)

Hypomethylation and expression of BEX2, IGSF4 and TIMP3 indicative of MLL translocations in Acute Myeloid Leukemia [PDF]

, 2009
Background Translocations of the Mixed Lineage Leukemia (MLL) gene occur in a subset (5%) of acute myeloid leukemias (AML), and in mixed phenotype acute leukemias in infancy - a disease with extremely poor prognosis.
Meyer, Claus, Röhrs, Sonja, Claus Meyer, Slany, Robert, Scherr, Michaela, Wilhelm G Dirks, Meyer Claus, Marschalek Rolf, Dirks, Wilhelm G., Quentmeier Hilmar, Wallace, Andrew, Scherr Michaela, Sonja Röhrs, Hans G Drexler, Drexler, Hans Günter, Quentmeier, Hilmar, Dirks Wilhelm G, Marschalek, Rolf (Prof. Dr.), Robert Slany, Drexler Hans G, Rolf Marschalek, Slany Robert, Andrew Wallace, Wallace Andrew, Röhrs Sonja, Michaela Scherr, Hilmar Quentmeier   +26 more
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Comparison of genetic and clinical aspects in patients with acute myeloid leukemia and myelodysplastic syndromes all with more than 50% of bone marrow erythropoietic cells

Haematologica, 2011
Background The World Health Organization separates acute erythroid leukemia (erythropoiesis in ≥50% of nucleated bone marrow cells; ≥20% myeloblasts of non-erythroid cells) from other entities with increased erythropoiesis – acute myeloid leukemia with ...
Ulrike Bacher, Claudia Haferlach, Tamara Alpermann, Wolfgang Kern, Susanne Schnittger, Torsten Haferlach   +5 more
doaj   +1 more source

NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia

Haematologica, 2008
Acute myeloid leukemia carrying NPM1 mutations and cytoplasmic nucleophosmin (NPMc+ acute myeloid leukemia) represents one-third of adult AML (50–60% of all acute myeloid leukemia with normal karyotype) and shows distinct biological, pathological and ...
Brunangelo Falini, Cristina Mecucci, Giuseppe Saglio, Francesco Lo Coco, Daniela Diverio, Patrick Brown, Fabrizio Pane, Marco Mancini, Maria Paola Martelli, Stefano Pileri, Torsten Haferlach, Claudia Haferlach, Susanne Schnittger   +12 more
doaj   +1 more source

Hypocellular acute myeloid leukemia in adults: analysis of the clinical outcome of 123 patients

Haematologica, 2012
Background The hypocellular variant of acute myeloid leukemia accounts for less than 10% of all cases of adult acute myeloid leukemia. It is defined by having less than 20 percent of cellular bone marrow in a biopsy at presentation.
Aref Al-Kali, Sergej Konoplev, Erpei Lin, Tapan Kadia, Stefan Faderl, Farhad Ravandi, Mohamad Ayoubi, Mark Brandt, Jorge E. Cortes, Hagop Kantarjian, Gautam Borthakur   +10 more
doaj   +1 more source

Feasibility of azacitidine added to standard chemotherapy in older patients with acute myeloid leukemia - a randomised SAL pilot study [PDF]

, 2012
INTRODUCTION: Older patients with acute myeloid leukemia (AML) experience short survival despite intensive chemotherapy. Azacitidine has promising activity in patients with low proliferating AML.
Ulrich Dührsen, Anja Koschmieder (106749), Matthias Stelljes, Christian Thiede (106768), Carsten Müller-Tidow, Nicola Tidow (106758), Noppeney, Richard, Utz Krug, Gerhard Ehninger, Daniela Schwammbach (106754), Steffen Koschmieder, Nicola Tidow, Wolfgang E Berdel, Markus Schaich (106764), Stelljes, Matthias, Matthias Stelljes (106772), Utz Krug (106744), Carsten Müller-Tidow (105305), Krug, Utz, Tidow, Nicola, Bug, Gesine, Schaich, Markus, Björn Steffen, Richard Noppeney (106769), Gerss, Joachim, Christian Thiede, Joachim Gerss, Schwammbach, Daniela, Thomas Büchner, Björn Steffen (106759), Büchner, Thomas, Ulrich Dührsen (106782), Anja Koschmieder, Christoph Röllig, Steffen, Björn, Markus Schaich, Steffen Koschmieder (106779), Thomas Büchner (106775), Hubert Serve, Koschmieder, Steffen, Christian H. Brandts (106762), Ehninger, Gerhard, Brandts, Christian Hubertus, Berdel, Wolfgang E., Joachim Gerss (106757), Gerhard Ehninger (106788), Dührsen, Ulrich, Wolfgang E. Berdel (106792), Richard Noppeney, Gesine Bug (106760), Serve, Hubert, Müller-Tidow, Carsten, Daniela Schwammbach, Christian H Brandts, Hubert Serve (106786), Thiede, Christian, Gesine Bug, Koschmieder, Anja, Röllig, Christoph, Christoph Röllig (106766), Koschmieder Steffen, Ehninger, G. (Gerhard), Schaich, M. (Markus), Tidow Nicola, Gerß, J. (Joachim), Müller-Tidow, C. (Carsten), Steffen Björn, Röllig, C. (Christoph), Thiede Christian, Dührsen, U. (Ulrich), Bug Gesine, Brandts, C.H. (Christian), Stelljes Matthias, Thiede, C. (Christian), Brandts Christian H., Noppeney, R. (Richard), Büchner, T. (Thomas), Schaich Markus, Tidow, N. (Nicola), Schwammbach, D. (Daniela), Röllig Christoph, Steffen, B. (Björn), Koschmieder Anja, Serve, H. (Hubert), Koschmieder, A. (Anja), Noppeney Richard, Bug, G. (Gesine), Krug Utz, Dührsen Ulrich, Stelljes, M. (Matthias), Berdel, W.E. (Wolfgang), Büchner Thomas, Schwammbach Daniela, Serve Hubert, Krug, U. (Utz), Berdel Wolfgang E., Ehninger Gerhard, Koschmieder, S. (Steffen), Gerss Joachim, Müller-Tidow Carsten   +99 more
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Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia

Haematologica, 2010
Background C-type lectin-like molecule-1 is a transmembrane receptor expressed on myeloid cells, acute myeloid leukemia blasts and leukemic stem cells.
Xiaoxian Zhao, Shweta Singh, Cecile Pardoux, Jingsong Zhao, Eric D. Hsi, Arie Abo, Wouter Korver   +6 more
doaj   +1 more source

Identification of cooperating genetic events in acute leukemia [PDF]

, 2009
The genetic alterations associated with acute leukemia can be divided into two functional groups. The class I mutations enhance cellular proliferation and survival by constitutive activation of mainly protein tyrosine kinases signaling pathways.
Liu, Ting
core   +1 more source

Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia

Haematologica, 2012
The recent identification of DNMT3A mutations in de novo acute myeloid leukemia prompted us to determine their frequency, patterns and clinical impact in a cohort of 98 patients with either therapy-related or secondary acute myeloid leukemia developing ...
Isabella Fried, Claudia Bodner, Monika M. Pichler, Karin Lind, Christine Beham-Schmid, Franz Quehenberger, Wolfgang R. Sperr, Werner Linkesch, Heinz Sill, Albert Wölfler   +9 more
doaj   +1 more source

Targeting the MLL complex in acute leukemia [PDF]

, 2014
Chromosomal rearrangements leading mostly to fusion oncoproteins of the Mixed Lineage Leukemia (MLL) gene occur in about 10% of all patients with acute leukemia and are often associated with poor clinical outcome, emphasizing the need for new treatment ...
Méreau, Hélène
core   +1 more source

Clonal leukemic evolution in myelodysplastic syndromes with TET2 and IDH1/2 mutations

Haematologica, 2014
Somatic mutations of TET2, IDH1, and IDH2 have been described in myelodysplastic syndrome. The impact of these mutations on outcome of myelodysplastic syndrome and their progression to secondary acute myeloid leukemia remains unclear.
Tung-Liang Lin, Yasunobu Nagata, Hsiao-Wen Kao, Masashi Sanada, Yusuke Okuno, Chein-Fuang Huang, Der-Cherng Liang, Ming-Chung Kuo, Chang-Liang Lai, En-Hui Lee, Yu-Shu Shih, Hiroko Tanaka, Yuichi Shiraishi, Kenichi Chiba, Tung-Huei Lin, Jin-Hou Wu, Satoru Miyano, Seishi Ogawa, Lee-Yung Shih   +18 more
doaj   +1 more source