Results 31 to 40 of about 442,026 (299)

Clinical and biological characteristics of adult biphenotypic acute leukemia in comparison with that of acute myeloid leukemia and acute lymphoblastic leukemia: a case series of a Chinese population

Haematologica, 2009
Background Biphenotypic acute leukemia is a rare disorder that is difficult to diagnose. It displays features of both myeloid and lymphoid lineage. There is still a lack of studies in biphenotypic acute leukemia in a Chinese population. We present here a
Xiao-Qian Xu, Jian-Min Wang, Shu-Qing Lü, Li Chen, Jian-Min Yang, Wei-Ping Zhang, Xian-Min Song, Jun Hou, Xiong Ni, Hui-Ying Qiu   +9 more
doaj   +1 more source

One Stone, Two Birds: N6-Methyladenosine RNA Modification in Leukemia Stem Cells and the Tumor Immune Microenvironment in Acute Myeloid Leukemia

Frontiers in Immunology, 2022
Acute myeloid leukemia is the most common acute leukemia in adults, with accumulation of abundant blasts and impairment of hematogenic function. Despite great advances in diagnosis and therapy, the overall survival of patients with acute myeloid leukemia
Xianfeng Ouyang, Xianfeng Ouyang, Yuping Gong   +2 more
doaj   +1 more source

Acute Myeloid Leukemia and Acute Promyelocytic Leukemia

Hematology, 2003
AbstractThe therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as
Bob, Löwenberg, James D, Griffin, Martin S, Tallman   +2 more
openaire   +2 more sources

Dendrogenin A drives LXR to trigger lethal autophagy in cancers

Nature Communications, 2017
Dendrogenin A, cholesterol metabolite, has tumor suppressive properties but the mechanisms are unknown. Here the authors show that Dendrogenin A can induce autophagy-mediated cell death in both melanoma and acute myeloid leukaemia.
Gregory Segala, Marion David, Philippe de Medina, Mathias C. Poirot, Nizar Serhan, François Vergez, Aurelie Mougel, Estelle Saland, Kevin Carayon, Julie Leignadier, Nicolas Caron, Maud Voisin, Julia Cherier, Laetitia Ligat, Frederic Lopez, Emmanuel Noguer, Arnaud Rives, Bruno Payré, Talal al Saati, Antonin Lamaziere, Gaëtan Despres, Jean-Marc Lobaccaro, Silvere Baron, Cecile Demur, Fabienne de Toni, Clément Larrue, Helena Boutzen, Fabienne Thomas, Jean-Emmanuel Sarry, Marie Tosolini, Didier Picard, Michel Record, Christian Récher, Marc Poirot, Sandrine Silvente-Poirot   +34 more
doaj   +1 more source

Functional Genomic Landscape of Acute Myeloid Leukemia

Nature, 2018
The implementation of targeted therapies for acute myeloid leukaemia (AML) has been challenging because of the complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events.
J. Tyner, C. Tognon, D. Bottomly, Beth Wilmot, S. Kurtz, Samantha Savage, Nicola Long, Anna Reister Schultz, E. Traer, Melissa L. Abel, A. Agarwal, A. Blucher, U. Borate, Jade Bryant, Russell T. Burke, A. Carlos, Richie Carpenter, J. Carroll, B. Chang, Cody Coblentz, A. D'Almeida, R. Cook, A. Danilov, K. Dao, Michie Degnin, D. Devine, J. Dibb, David K Edwards, C. Eide, I. English, J. Glover, Rachel Henson, Hibery Ho, Abdusebur Jemal, Kara Johnson, Ryan C. Johnson, Brian Junio, A. Kaempf, Jessica T. Leonard, Chen-Jzong Lin, S. Liu, Pierrette Lo, M. Loriaux, Samuel B. Luty, T. Macey, Jason D. MacManiman, Jacqueline Martinez, M. Mori, D. Nelson, Ceilidh Nichols, Jill Peters, Justin W Ramsdill, Angela Rofelty, Robert Schuff, R. Searles, E. Segerdell, Rebecca Smith, S. Spurgeon, Tyler Sweeney, Aashis Thapa, Corinne Visser, Jacob P. Wagner, Kevin Watanabe-Smith, Kristen Werth, Joelle Wolf, Libbey White, Amy Yates, Haijiao Zhang, C. Cogle, R. Collins, D. Connolly, M. Deininger, L. Drusbosky, C. Hourigan, C. Jordan, P. Kropf, Tara L. Lin, M. Martinez, B. Medeiros, Rachel R. Pallapati, D. Pollyea, R. Swords, J. Watts, S. Weir, D. Wiest, R. M. Winters, S. McWeeney, B. Druker   +87 more
semanticscholar   +1 more source

Unified classification and risk-stratification in Acute Myeloid Leukemia

Nature Communications, 2022
Clinical recommendations for Acute Myeloid Leukemia (AML) classification and risk-stratification remain heavily reliant on cytogenetic findings at diagnosis, which are present in
Yanis Tazi, J. Arango-Ossa, Yangyu Zhou, E. Bernard, Ian Thomas, A. Gilkes, S. Freeman, Y. Pradat, S. Johnson, R. Hills, R. Dillon, M. Levine, D. Leongamornlert, A. Butler, A. Ganser, L. Bullinger, K. Döhner, O. Ottmann, R. Adams, H. Döhner, P. Campbell, A. Burnett, M. Dennis, N. Russell, S. Devlin, B. Huntly, E. Papaemmanuil   +26 more
semanticscholar   +1 more source

Pharmacological inhibition of dihydroorotate dehydrogenase induces apoptosis and differentiation in acute myeloid leukemia cells

Haematologica, 2018
Acute myeloid leukemia is a disorder characterized by abnormal differentiation of myeloid cells and a clonal proliferation derived from primitive hematopoietic stem cells.
Dang Wu, Wanyan Wang, Wuyan Chen, Fulin Lian, Li Lang, Ying Huang, Yechun Xu, Naixia Zhang, Yinbin Chen, Mingyao Liu, Ruth Nussinov, Feixiong Cheng, Weiqiang Lu, Jin Huang   +13 more
doaj   +1 more source

FTO plays an oncogenic role in acute myeloid leukemia as a N6-methyladenosine RNA demethylase

Cancer Cell, 2016
SUMMARY N6-methyladenosine (m6A) represents the most prevalent internal modification in mammalian mRNAs. Despite its functional importance in various fundamental bioprocesses, the studies of m6A in cancer have been limited.
Zejuan Li, Hengyou Weng, R. Su, X. Weng, Zhixiang Zuo, Chenying Li, Huilin Huang, S. Nachtergaele, Lei Dong, Chao Hu, Xi Qin, Li-Juan Tang, Yungui Wang, Gia-ming Hong, Hao Huang, Xiao Wang, Ping Chen, S. Gurbuxani, Stephen Arnovitz, Yuanyuan Li, Shenglai Li, J. Strong, Mary Beth Neilly, R. Larson, Xi Jiang, Pumin Zhang, Jie Jin, Chuan He, Jianjun Chen   +28 more
semanticscholar   +1 more source

NCCN Guidelines Insights: Acute Myeloid Leukemia, Version 2.2021.

The Journal of the National Comprehensive Cancer Network, 2021
The NCCN Guidelines for Acute Myeloid Leukemia (AML) provide recommendations for the diagnosis and treatment of adults with AML based on clinical trials that have led to significant improvements in treatment, or have yielded new information regarding ...
D. Pollyea, D. Bixby, A. Perl, V. Bhatt, J. Altman, F. Appelbaum, Marcos de Lima, A. Fathi, J. Foran, I. Gojo, Aric Hall, Meagan A. Jacoby, J. Lancet, G. Mannis, G. Marcucci, Mike G Martin, A. Mims, Jadee L. Neff, R. Nejati, R. Olin, M. Percival, T. Prebet, Amanda C. Przespolewski, D. Rao, F. Ravandi-Kashani, P. Shami, R. Stone, S. Strickland, K. Sweet, P. Vachhani, M. Wieduwilt, K. Gregory, Ndiya Ogba, M. Tallman   +33 more
semanticscholar   +1 more source

Progress in Acute Myeloid Leukemia [PDF]

Clinical Lymphoma Myeloma and Leukemia, 2015
Significant progress has been made in the treatment of acute myeloid leukemia (AML). Steady gains in clinical research and a renaissance of genomics in leukemia have led to improved outcomes. The recognition of tremendous heterogeneity in AML has allowed individualized treatments of specific disease entities within the context of patient age ...
Kadia, Tapan M, Ravandi, Farhad, O'Brien, Susan, Cortes, Jorge, Kantarjian, Hagop M   +4 more
openaire   +4 more sources