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Acute Decompensation and Acute-on-Chronic Liver Failure
Clinics in Liver Disease, 2021 Liver cirrhosis is a major healthcare problem. Acute decompensation, and in particular its interplay with dysfunction of other organs, is responsible for the majority of deaths in patients with cirrhosis. Acute decompensation has different courses, from stable decompensated cirrhosis over unstable decompensated cirrhosis to pre-acute-on-chronic liver ...
Ferstl, Philip, Trebicka, Jonel
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The Role of Monocytes and Macrophages in Acute and Acute-on-Chronic Liver Failure
Frontiers in Immunology, 2018 Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display evidence of a pro-inflammatory state with local liver inflammation ...
Evangelos Triantafyllou +6 more
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Ammonia toxicity: from head to toe? [PDF]
, 2016 Ammonia is diffused and transported across all plasma membranes. This entails that hyperammonemia leads to an increase in ammonia in all organs and tissues.
Dasarathy, Srinivasan +6 more
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Medicina, 2023 Both the Chronic Liver Failure Consortium (CLIF-C) organ failure score (OFs) and the CLIF-C acute-on-chronic-liver failure (ACLF) score (ACLFs) were developed for risk stratification and to predict mortality in patients with liver cirrhosis and ACLF ...
Michael Nagel +7 more
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Matrix metalloproteinases in liver injury, repair and fibrosis. [PDF]
, 2015 The liver is a large highly vascularized organ with a central function in metabolic homeostasis, detoxification, and immunity. Due to its roles, the liver is frequently exposed to various insults which can cause cell death and hepatic dysfunction ...
Baber, John +3 more
core +1 more source
Liver Transplantation for Acute on Chronic Liver Failure [PDF]
Journal of Clinical and Experimental Hepatology, 2017 Acute-on chronic liver failure (ACLF) is defined as acute insult on previous liver disease that causes sudden worsening of liver functions.ACLF is characterized by high incidence of organ failure and prognosis is remarkably worse than patients with cirrhosis. Incidence of organ failures is very high despite best medical care and timely liver transplant
Narendra S. Choudhary +3 more
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Plasma Glutamine Concentrations in Liver Failure. [PDF]
PLoS ONE, 2016 Higher than normal plasma glutamine concentration at admission to an intensive care unit is associated with an unfavorable outcome. Very high plasma glutamine levels are sometimes seen in both acute and chronic liver failure.
Gunnel Helling +7 more
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Effect of acute on chronic liver failure over post-transplant survival
Annals of Hepatology, 2023 Introduction and Objectives: Acute-on-chronic liver failure (ACLF) is associated with reduced short-term survival, and liver transplantation is frequently the only therapeutic option.
Carlos Benítez +18 more
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Liver transplantation for acute-on-chronic liver failure from erythropoietic protoporphyria [PDF]
Clinical and Molecular Hepatology, 2012 Erythropoietic protoporphyria (EPP) is an inherited disorder of the heme metabolic pathway that is characterized by accumulation of protoporphyrin in the blood, erythrocytes, and tissues, and cutaneous manifestations of photosensitivity, all resulting ...
Pyoung-Jae Park +9 more
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Liver transplantation for acute-on-chronic liver failure
Best Practice & Research Clinical Anaesthesiology, 2020 Acute-on-chronic liver failure (AoCLF) represents a newly defined entity in patients with liver disease leading to multiple organ failures and increased mortality. To date, no universally accepted definition exists, and different academic societies developed guidelines on the early diagnosis and classification of AoCLF.
Dana Tomescu +2 more
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