Results 211 to 220 of about 7,088,301 (243)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

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Depression, anxiety and acute pain: links and management challenges

Postgraduate Medicine, 2019
Pain is a subjective experience that is influenced by genetics, gender, social, cultural and personal parameters. Opposed to chronic pain, which by definition has to last for at least 3 months, acute pain is mostly because of trauma, acute medical ...
Panagiotis Zis, Athena Michaelides
exaly   +2 more sources

Selective Inhibition of NaV1.8 with VX-548 for Acute Pain.

New England Journal of Medicine, 2023
BACKGROUND The NaV1.8 voltage-gated sodium channel, expressed in peripheral nociceptive neurons, plays a role in transmitting nociceptive signals. The effect of VX-548, an oral, highly selective inhibitor of NaV1.8, on control of acute pain is being ...
Jim Jones, D. Correll, S. Lechner, Ina Jazic, Xiaopeng Miao, David Shaw, C. Simard, Jeremiah D. Osteen, B. Hare, Alina Beaton, Todd Bertoch, A. Buvanendran, A. S. Habib, L. Pizzi, R. Pollak, S. Weiner, C. Bozic, PaulA . Negulescu, P. White   +18 more
semanticscholar   +1 more source

Nonpharmacologic and Pharmacologic Management of Acute Pain From Non–Low Back, Musculoskeletal Injuries in Adults: A Clinical Guideline From the American College of Physicians and American Academy of Family Physicians

Annals of Internal Medicine, 2020
DESCRIPTION The American College of Physicians (ACP) and American Academy of Family Physicians (AAFP) developed this guideline to provide clinical recommendations on nonpharmacologic and pharmacologic management of acute pain from non-low back ...
A. Qaseem, R. McLean, David O’Gurek, P. Batur, Kenneth W. Lin, D. Kansagara   +5 more
semanticscholar   +1 more source

Is the minimal clinically important difference (MCID) in acute pain a good measure of analgesic efficacy in regional anesthesia?

Regional anesthesia and pain medicine, 2020
In the field of acute pain medicine research, we believe there is an unmet need to incorporate patient related outcome measures that move beyond reporting pain scores and opioid consumption.
Felipe Muñoz-Leyva, K. El-Boghdadly, V. Chan   +2 more
semanticscholar   +1 more source

Racial and ethnic disparities in the management of acute pain in US emergency departments: Meta-analysis and systematic review.

American Journal of Emergency Medicine, 2019
OBJECTIVE This review aims to quantify the effect of minority status on analgesia use for acute pain management in US Emergency Department (ED) settings.
P. Lee, Maxine A. Le Saux, R. Siegel, M. Goyal, Chen Chen, Yan Ma, A. Meltzer   +6 more
semanticscholar   +1 more source

Risk factors for severe acute pain and persistent pain after surgery for breast cancer: a prospective observational study

Regional anesthesia and pain medicine, 2019
Background and objectives There are few prospective studies providing comprehensive assessment of risk factors for acute and persistent pain after breast surgery.
A. Habib, M. Kertai, M. Cooter, R. Greenup, Shelley Hwang   +4 more
semanticscholar   +1 more source

Laws limiting the prescribing or dispensing of opioids for acute pain in the United States: A national systematic legal review.

Drug and Alcohol Dependence, 2019
BACKGROUND Opioid overdose is a continuing public health crisis. In response to an increasing recognition of the negative outcomes sometimes associated with the use of opioid analgesics, states have taken a number of steps attempting to reduce ...
C. Davis, Amy Judd Lieberman, H. Hernandez-Delgado, C. Suba   +3 more
semanticscholar   +1 more source

Intravenous Lidocaine for Acute Pain: A Systematic Review

Pharmacotherapy, 2018
This systematic review evaluates the safety and efficacy of intravenous (IV) lidocaine for the treatment of acute pain in adult patients. The PubMed database was searched for randomized controlled trials, retrospective cohort studies, case series, and ...
D. Masic, Edith Liang, Christina Long, Ethan Sterk, Brian Barbas, M. Rech   +5 more
semanticscholar   +1 more source

Acute Pain

Pain Care Essentials, 2019
Chapter 14 covers the essentials of acute pain care in the hospital and procedural setting. The chapter begins with an overview of the negative physiologic impacts of uncontrolled acute pain.
N. Zinboonyahgoon, Kristin L. Schreiber
semanticscholar   +1 more source