Results 51 to 60 of about 1,452,841 (291)

Factors Influencing Satisfaction with Patient-Controlled Analgesia Among Postoperative Patients Using a Generalized Ordinal Logistic Regression Model

Asian Nursing Research, 2020
Summary: Purpose: The purpose of this study was to identify the factors affecting the satisfaction with patient-controlled analgesia (PCA) of patients using a generalized ordinal logistic regression model and to evaluate the difference in results of the
Wonhee Baek, Yeonsoo Jang, Chang Gi Park, Mir Moon   +3 more
doaj   +1 more source

Practical and clinical utility of non-invasive vagus nerve stimulation (nVNS) for the acute treatment of migraine. A post hoc analysis of the randomized, sham-controlled, double-blind PRESTO trial [PDF]

, 2018
Background: The PRESTO study of non-invasive vagus nerve stimulation (nVNS; gammaCore®) featured key primary and secondary end points recommended by the International Headache Society to provide Class I evidence that for patients with an episodic ...
Ambrosini, A, Andersson, A, Anna, Ambrosini, Aurilia, C, Baldi, Mg, Barbanti, P, Bernetti, L, Bianchi, M, Bitetto, V, Cevoli, S, Chiariello, Ga, Chiarugi, A, Corbelli, I, Cortelli, P, Cristina, Tassorelli, De Cesaris, F, De Icco, R, De Martino, P, de Tommaso, M, Di Maro, D., Egeo, G, Eric, Liebler, Fofi, L, Gai, A, Geppetti, P, Giulia, Pierangeli, Govone, F, Grazzi, L, Licia GrazziEmail author,, Liebler, E, Lupi, C, Marin, J, Marina de Tommaso,, Marone, I, Martelletti, P, Martinelli, D, Masuzzo, F, McClure, C, Negro, A, Padovan, Am, Paola, Sarchielli, Paolo, Martelletti, Perrotta, A, Pierangeli, G, Pierangelo, Geppetti, Puma, Sl, Rainero, I, Rainero, Innocenzo, Ricci, K, Romoli, M, Rubino, E, Sances, G, Sarchielli, P, Simoni, S, Spitzer, L, Tassorelli C, Piero Barbanti PRESTO Study Group., Terlizzi, R, Thackeray, L, Torrieri, Mc, Vacca, A, Vecchio, E, Verzina, A   +61 more
core   +2 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Systemic Exercise-Induced Hypoalgesia Following Isometric Exercise Reduces Conditioned Pain Modulation [PDF]

, 2018
Objective Physically active individuals show greater conditioned pain modulation (CPM) compared with less active individuals. Understanding the effects of acute exercise on CPM may allow for a more targeted use of exercise in the management of pain. This
Alsouhibani, Ali, Bement, Marie K. Hoeger, Vaegter, Henrik Bjarke   +2 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Incentives for Combining Structure and Process Quality to Improve Outcome in Rheumatic Treatment

SAGE Open, 2022
The study investigates the effects of multidisciplinary treatment for rheumatic treatment regarding (a) financial feasibility based on costs/remuneration in comparison to conventional treatment and (b) Patient reported outcome measures (Proms) to check ...
Tobias Romeyke, Elisabeth Noehammer, Harald Stummer   +2 more
doaj   +1 more source

A rare cause of acute abdomen: radiotherapy-induced bladder rupture [PDF]

, 2016
Introduction: Spontaneous intraperitoneal rupture of the bladder, which is rare, is a life-threatening condition. In emergency services, when patients present with lower quadrant abdominal pain and acute renal failure in the patient's laboratory findings
Başer, Aykut, Başer, Hülya Yılmaz, Erdur, Bülent, Zümrütbaş, Ali Ersin   +3 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Acute low back pain is marked by variability: An internet-based pilot study [PDF]

, 2011
Background Pain variability in acute LBP has received limited study. The objectives of this pilot study were to characterize fluctuations in pain during acute LBP, to determine whether self-reported 'flares' of pain represent discrete periods of ...
Pradeep Suri, James Rainville, Garrett M Fitzmaurice, Jeffrey N Katz, Robert N Jamison, Julia Martha, Carol Hartigan, Janet Limke, Cristin Jouve, David J Hunter   +9 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source