Results 101 to 110 of about 593,677 (304)

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, EarlyView.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

MYCOBACTERIUM TUBERCULOSIS BIOLOGICAL PROPERTIES AND CHARACTERISTICS OF THE INFLAMMATORY REACTION IN PATIENTS WITH INFILTRATIVE PULMONARY TUBERCULOSIS

Инфекция и иммунитет, 2014
Host-pathogen relations were analyzed on basis of the results of examinations of 42 patients with newly diagnosed, previously untreated infiltrative pulmonary tuberculosis (IPT) with regard for the biological characteristics of Mycobacterium tuberculosis
O. T. Titarenko, M. E. Dyakova, O. A. Manicheva, D. S. Esmedlyaeva, M. Z. Dogonadze, N. P. Alexeyeva, T. L. Perova, N. N. Melnikova   +7 more
doaj   +1 more source

The Immunologic Properties and Identity of Mucopolysaccharides Associated with C-Reactive Protein in Acute Phase Human Serum [PDF]

, 1967
Y. Hokama, Monroe Coleman, Richard F. Riley   +2 more
openalex   +1 more source

Elevation of Intact and Proteolytic Fragments of Acute Phase Proteins Constitutes the Earliest Systemic Antiviral Response in HIV-1 Infection

PLoS Pathogens, 2010
The earliest immune responses activated in acute human immunodeficiency virus type 1 infection (AHI) exert a critical influence on subsequent virus spread or containment.
H. Kramer, Kerry J. Lavender, L. Qin, Andrea R. Stacey, Michael K P Liu, K. di Gleria, A. Simmons, N. Gasper-Smith, B. Haynes, A. McMichael, P. Borrow, B. Kessler   +11 more
semanticscholar   +1 more source

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

Molecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

Characterization of Acute-Phase Proteins (Apps) [PDF]

, 2012
Upon Injury, a complex biological response of tissues is initiated to protect the organism and remove the injurious stimuli then trigger the healing process. Inflammation is a part of this complex response. The local response to tissue injury or infection is acute inflammation. Without inflammation, wounds and infections would never heal. This response
Ying Chu Lee, Sin Tak Chu
openaire   +3 more sources

Etoposide‐induced cancer cell death: roles of mitochondrial VDAC1 and calpain, and resistance mechanisms

Molecular Oncology, EarlyView.
The complex mode of action of the topoisomerase II inhibitor etoposide in triggering apoptosis involves several mechanisms: overexpression of the mitochondrial protein VDAC1, leading to its oligomerization and formation of a large channel that mediates the release of pro‐apoptotic protein; and overexpression of the apoptosis regulators p53, Bax, and ...
Aditya Karunanithi Nivedita, Varda Shoshan‐Barmatz   +1 more
wiley   +1 more source

Messenger RNA activities of four acute phase proteins during inflammation [PDF]

, 1983
Wolfgang Northemann, Tilo Andus, Volker Groß, Mariko Nagashima, Gerhard Schreiber, Peter C. Heinrich   +5 more
openalex   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Evaluation of acute phase protein indexes in dogs with leishmaniasis at diagnosis, during and after short-term treatment

Veterinární Medicína, 2005
An acute phase index based on a combination of acute phase proteins which permitted monitoring the response to therapy of canine leishmaniasis was developed and evaluated in this study. Six dogs naturally infected by Leishmania infantum were treated with
S. Martinez-Subiela, J.J. Ceron
doaj   +1 more source