Results 71 to 80 of about 4,908,147 (289)

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Hypokalemic Rhabdomyolysis Induced Acute Renal Failure As a Presentation of Coeliac Disease

Balkan Medical Journal, 2012
Adult coeliac disease commonly presents without classical symptoms as chronic diarrhea and weight loss. We describe the case of a 31-year-old woman with persistent life-threatening hypokalemia, acute renal failure, and acute quadriplegia due to diarrhea ...
Funda Sarı, Ayşe Güneş, Metin Sarıkaya, Mustafa Eren, Ahmet Korkmaz, Ramazan Çetinkaya, Hasan Can, Nur Tukel   +7 more
doaj  

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Acute renal failure due to rhabdomyolysis following a seizure

Journal of Family Medicine and Primary Care, 2013
Acute renal failure, oliguric or nonoliguric, is the most common complication of rhabdomyolysis. Rhabdomyolysis should be suspected in patients presenting with states of increased muscular activity, such as seizures, agitation, strenuous muscle exercise,
Ajay Mishra, Nikhil Dave
doaj   +1 more source

Acute renal failure in pregnancy

Kidney International, 1980
Since the dramatic decrease in the incidence of septic abortion in industrialized countries, acute renal failure (ARF) complicating pregnancy represents a small percentage of the cases of acute renal shutdown, falling in France from 40% in 1966 to 4.5% in 1978 [1]. It is underlined in most series that the mortality rate in ARF associated with pregnancy
Grünfeld, Jean-Pierre, Ganeval, Dominique, Bournérias, François   +2 more
openaire   +2 more sources

A Modified Sequential Organ Failure Assessment Score to Predict Hospital Mortality of Postoperative Acute Renal Failure Patients Requiring Renal Replacement Therapy

, 2011
Background: A predictive model for hospital mortality in postoperative acute renal failure (ARF) patients requiring renal replacement therapy ( RRT) may aid clinicians' therapeutic decision-making and research design. Methods: A prospective observational
LIN, YU-FENG;KO, WEN-JE;WU, VIN-CENT;CHEN, YIH-SHARNG;CHEN, YUNG-MING;HU, FU-CHANG;SHIAO, CHIH-CHUNG;WU, MING-SHIOU;CHEN, YUNG-WEI;LI, WEN-YI;HUANG, TAO-MIN;WU, KWAN-DUN;CHU, TZONG-SHINN, 林裕峯;柯文哲;吳允升;陳益祥;陳永銘;胡賦强;蕭志忠;吳明修;陳詠瑋;李玟儀;黃道民;吳寬墩;朱宗信   +1 more
core   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

ACUTE RENAL INJURY IN THE PERI-OPERATIVE PERIOD

Вестник анестезиологии и реаниматологии, 2018
Acute renal injury is a relatively new notion (introduced into the practice since 2012), which is currently understood as a fast failure of renal functions (within 48 hours) with increasing absolute rates of serum creatinine up to 26.5 mcmol/l and more ...
D. V. Sokolov, Yu. S. Polushin
doaj   +1 more source

An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. [PDF]

, 2014
BACKGROUND: Organ dysfunction consequent to infection ('severe sepsis') is the leading cause of admission to an intensive care unit (ICU). In both animal models and early clinical studies the calcium channel sensitizer levosimendan has been demonstrated ...
McAuley, Daniel F, Orme, RML, Singer, M, L'E Orme, Robert M, Alexina J Mason, McAuley DF, Mason, Alexina J., Orme, Robert M L'E, Ashby D, Orme, Robert M., Mason, Alexina J, Liu, KD, Perkins, Gavin D., McAuley, Daniel F.; id_orcid, Gordon, Anthony C., Robert M Orme, Daniel F McAuley, Mason, AJ, Gordon, Anthony C, Gordon AC, Liu, Kathleen D., Orme RM, Gordon, AC, Mervyn Singer, Perkins, GD, Kathleen D Liu, Mason AJ, McAuley, Daniel F., Liu KD, Andrea Morelli, Ashby, D, Liu, Kathleen, Liu, Kathleen D, Gavin D Perkins, Morelli, A, Singer, Mervyn, Singer M, Perkins, Gavin D, Ashby, Deborah, Anthony C Gordon, Deborah Ashby, Orme, Robert MLE, Morelli, Andrea, Perkins GD, McAuley, DF   +44 more
core   +1 more source

In Situ Genetic Engineering Facilitates MMP‐9‐Responsive TIMP1 Release Through Proteolytic Cleavage to Boost Diabetic Wound Healing

Advanced Science, EarlyView.
This study develops an MMP‐9‐responsive protein release system that transforms resident cells into drug depots through in situ genetic engineering. Anchored to the membrane, the therapeutic protein TIMP1 is selectively released upon MMP‐9 cleavage.
Yuan Zhang, Jiani Deng, Man Yee Cheung, Tingting Fu, Xufeng Qi, Dongqing Cai, Jianmin Sun, Gang Lu, Peng Shi, Wai‐Yee Chan, Xu Li, Hui Zhao   +11 more
wiley   +1 more source