Results 181 to 190 of about 1,201,249 (376)

Airway occlusion pressure (P0.1) — A useful predictor for the weaning outcome in patients with acute respiratory failure — [PDF]

, 1990
Kazufumi Okamoto, Toshihide Sato, Tohru Morioka   +2 more
openalex   +1 more source

Skullcapflavone II Inhibits SLC1A4‐Mediated L‐Serine Uptake and Promotes Mitochondrial Damage in Gastric Cancer

Advanced Science, EarlyView.
Skullcapflavone II (SkII) significantly alters serine metabolism in gastric cancer cells by directly targeting the L‐serine transporter SLC1A4, thereby inhibiting L‐serine uptake rather than de novo synthesis. This disruption of serine metabolism by SkII leads to increased oxidative stress and consequent mitochondrial damage.
Jing Zhao, Yu‐Bo Ma, Rui‐Hong Xia, Zheng‐Chen Jiang, Ying Zhou, Ya‐Nan Wang, Meng‐Yan Yang, Jing‐Jie Dai, Tao Zhu, Li‐Bin Pan, Li Yuan   +10 more
wiley   +1 more source

Respiratory response to CO2 in patients with chronic obstructive pulmonary disease in acute respiratory failure [PDF]

, 1993
Catherine Tardif, G. Bonmarchand, JF Gibon, M.F. Hellot, J Leroy, P Pasquis, J. Milic‐Emili, Derenne Jp   +7 more
openalex   +1 more source

The CXCL10‐CXCR3 Axis Induces Tumor‐Associated Neutrophils to Interfere with CTLs‐Mediated Antitumor Activity in EBV‐Associated Epithelial Cancers

Advanced Science, EarlyView.
Compared with EBV‐negative epithelial cancer cells, EBV‐associated epithelial cancer cells exhibit enhanced secretion of chemokines, including CXCL10 and CCL5, to attract neutrophils. Via the CXCL10‐CXCR3 axis‐mediated positive feedback loop, neutrophils within EBV‐associated epithelial cancer cells are induced to form abundant NETs, which facilitate ...
Dijun Ouyang, Tong Xiang, Yuanyuan Chen, Mengjia Song, Jingjing Zhao, Hao Chen, Si Li, Lifeng Zhang, Chi Xu, Yan Ren, Yong Tao, Qijing Wang, Jia He, Yongqiang Li, Sisi Xie, Yuanyuan Liu, Yan Wang, Xinyi Yang, Jinqi You, Songzuo Xie, Yingzi Li, Desheng Weng, Qiuzhong Pan, Qi Yang, Jianchuan Xia   +24 more
wiley   +1 more source

Acute/Chronic respiratory failure [PDF]

, 1992
C. De La Cruz, A. Criado, L. Diaz, A. Seiz, P. L. Vidaur, J. R. Fraile, Kriton S. Filos, Leonidas C. Goudas, D. Dougenis, Vassilios Tassoudis, Ourania Patroni, Walther‐Benedikt Winkler, R Karnik, O. Seelmann, J. Havlicek, J. Stany, H. Becker, J. H. Peter, W. Pitzer, Heiko Schneider, P. von Wichert, R. A. De Blasi, Giorgio Conti, Consalvo Mattia, A. M. Mega, Marco Ferrari, A Gasparetto, H. Steltzer, M. Hiesmayr, P. Krafft, R. Petcold, Kathrin Strasser, A. F. Hammerle, G. Capellier, Shinta Liauw, T. Wintoh, John C. Marshall, Wilfred Demajo, F Barale, P M Walker, Thierry Dugernier, P. F. Laterre, G. Deby‐Dupont, Maurice Lamy, Marc Reynaert, P. Navarrete, Guillermo Vázquez, Ramón Rivera Espinosa, Erlinda Fernández, A. Mérida, Johannes Boch, K. Eibenberger, Christian Herold, W Schlick, R. M. J. L. van der Heijde, Hans Grotjohan, A. Versprille, C. A. Wagenvoort, Pieter G. Raijmakers, A. B. J. Groeneveld, A. J. Schneider, Han Rauwerda, G. J. J. Teule, L. G. Thija, Morley M. Singer, Joost S.P. Vermaat, G.M. Hall, G. Latter, Manish M. Patel, J. R. C. Jansen, F. Bordet, A. Mercatello, B. Coronel, M. Bret, J. D. Tlgaud, E. Archimbaud, J. F. Moskovtchenko, L. Gregorakos, Ch. Katsanos, Argyris Michalopoulos, V. Malessios, D. Mavropanou, J. Nicolopoulos, Klimentini E. Karageorgiou, E. Tognet, P. Huici Polo, Yves Devaux, D Fière, Päivi Valta, J. Takala, Francesco De Blasio, E. Iannuzzi, A. De Sio, Fausto Ferraro, Fernando Schiraldi, G Mostarda, N. Spannbrucker, U. Kiesow, R. Kleinschmidt, P. Reper   +99 more
openalex   +1 more source

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Continuous positive airway pressure (CPAP) vs. intermittent mandatory pressure release ventilation (IMPRV) in patients with acute respiratory failure [PDF]

, 1992
Jean‐Jacques Rouby, M. Ben Ameur, D. Jawish, A. Chérif, А. С. Андреев, Sophie Dreux, P. Viars   +6 more
openalex   +1 more source

STAT6 Activation Exacerbates Ferroptosis in Airway Epithelium by Inhibiting PRKN‐Mediated Mitophagy in Pulmonary Fibrosis

Advanced Science, EarlyView.
This study uncovers STAT6‐driven pulmonary fibrosis (PF) via suppression of PRKN‐mediated airway epithelial mitophagy, triggering mitochondrial dysfunction and ferroptosis. Rifabutin is identified as a potent STAT6 inhibitor that effectively reverses fibrotic progression. These findings reveal the STAT6‐PRKN axis as a pathogenic regulator and provide a
Youjing Yang, Guangbin Huang, Tao Zhang, Yi Ling, Junyu Jiang, Dingyuan Du, Yu Ma, Shasha Tao   +7 more
wiley   +1 more source

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2+ Smooth Muscle Cells

Advanced Science, EarlyView.
Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao, Huanhuan Cao, Meifang Wu, Zhihuang Qiu, Yuling Zhang, Yue Shen, Qiuyu Huang, Zhiyong Lin, Lemin Zheng, Liangwan Chen   +18 more
wiley   +1 more source

Reply to: Diaphragm excursion and diaphragm thickening fraction: commonality and conflict

European Respiratory Review
Diego Poddighe, Alexandros Kalkanis, Dries Testelmans, Greet Hermans, Daniel Langer, on behalf of all authors of “Respiratory muscle dysfunction in acute and chronic respiratory failure: how to diagnose and how to treat?”   +5 more
doaj   +1 more source