Results 201 to 210 of about 708,169 (323)

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Metabolomic biomarkers predict long-term physical function in survivors of acute respiratory failure. [PDF]

Respir Res
Haastrup AI, Roberts JT, Gandotra S, Hartsell EM, Daly GT, Pastukh VM, Purcell LD, Benton RG, Files DC, Stevens T, Gillespie MN, Morris PE, Langley RJ.   +12 more
europepmc   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

A Silent Threat: Acute Respiratory Failure and Os Odontoideum in a Child With Down's Syndrome. [PDF]

Cureus
Pasku D, Masarwa R, Bhanushali AK, Najjar E, Nocun W, D'Aquino D.   +5 more
europepmc   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Applying journey mapping and human-centered design to improve critical care delivery for patients with acute respiratory failure. [PDF]

BMC Health Serv Res
Golden SE, Lyons PG, Young A, Warner S, Tuepker A, Ilea I, Sullivan DR, Slatore CG, Vranas KC.   +8 more
europepmc   +1 more source

Non‐Invasive Assessment of Respiratory Mechanics Using Anatomical M‐Mode Ultrasound in Acute Pulmonary Oedema With Impending Respiratory Failure: A Case Report [PDF]

Timothy Kangwei Wong, Albert Yick Hou Lim, Lee Chiao Hao   +2 more
openalex   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

An Early Warning Marker in Acute Respiratory Failure: The Prognostic Significance of the PaCO₂-ETCO₂ Gap During Noninvasive Ventilation. [PDF]

Medicina (Kaunas)
Kırık S, Efgan MG, Bora ES, Tavşanoğlu U, Öz HÖ, Acar B, Yıldızlı S.   +6 more
europepmc   +1 more source

A new portable and ready-to-use device for out-of-hospital non-invasive treatment of acute respiratory failure: preclinical validation

openalex   +1 more source