Results 181 to 190 of about 4,006,034 (296)

Intentional Large-Volume Diazinon Ingestion Complicated by Seizure and Acute Respiratory Failure: A Case Report. [PDF]

Cureus
Alnuaimi KH, Alharmoodi S, Almerri R, Alneyadi M, Al Harthi A.   +4 more
europepmc   +1 more source

Acute respiratory failure

Acute respiratory failure (ARF) is the inability of the respiratory system to continue oxygenation or to eliminate carbon dioxide. ARF is a common life-threatening medical condition with multiple underlying etiologies. A comprehensive evaluation of these
Akarca F.K.
core  

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

A polymicrobial opportunistic infection leading to osteolytic destruction and acute respiratory failure: a case report. [PDF]

BMC Infect Dis
Huang Y, Zheng F, Cao W, Qiu Y, Pan M, Lin H, Yu H, Zhang J.   +7 more
europepmc   +1 more source

Renal Clearable Luminogenic Reporter for Ultrasensitive Influenza Virus Imaging and Efficient Antiviral Therapies Monitoring in Living Mice

Advanced Science, EarlyView.
A viral luminogenic reporter with chemiluminescence/fluorescence dual‐response and efficient renal clearance was developed for non‐invasive imaging and urinalysis of H1N1 virus protease, allowing for remote detection of H1N1 virus infections and monitoring of antiviral therapeutic efficacy in living mice.
Bankang Ruan, Chudan Liang, Meilin Hu, Weiping Xu, Jingjing Che, Jun Qian, Bingcai Jiang, Linna Liu, Xiancai Ma, Jiaguo Huang   +9 more
wiley   +1 more source

Reproducible clinical archetypes in acute respiratory failure: a multi-cohort trajectory analysis. [PDF]

Intensive Care Med
Marshall DC, Green AD, Komorowski M, Patel BV, Parbhoo S, Antcliffe DB.   +5 more
europepmc   +1 more source

Reversing Temozolomide Resistance in Glioblastoma Based on Cuproptosis‐Mediated Positive Feedback Loop

Advanced Science, EarlyView.
To effectively reverse TMZ resistance, this work proposes a cuproptosis‐mediated positive feedback loop that integrates mitochondrial dysfunction, ATP depletion, AMPK‐p53 signaling, and glycolytic inhibition, ultimately amplifying cell death. This cuproptosis‐mediated feedback loop simultaneously disrupts multiple resistance pathways in GBM, including ...
Wenjie Feng, Rui Yang, Chang Weng, Chen Li, Wanrui Shi, Yang Chen, Yang Yang, Yi Liu, Pengfei Ge, Hao Zhang   +9 more
wiley   +1 more source

Inflammatory biomarkers associated with infection-related type I acute respiratory failure. [PDF]

World J Emerg Med
Ren K, Xu J, Wang Y, Li Y, Zhu H.
europepmc   +1 more source

Harmonizing Rigidity and Flexibility: Embedding COF Quantum Dots Into Extracellular Matrix Gel as Carbon Monoxide Depot for Acoustically Triggered Time‐Programmable Anti‐Infective Therapy

Advanced Science, EarlyView.
A rigid‑flexible integrated CO depot is engineered by embedding rigid COFQDs into a flexible ECM gel network. The rigid framework enables high‑capacity CO storage and sonodynamic bacterial killing, while the flexible ECM gel controls sustained CO release, collectively eradicating multidrug‑resistant infection and promoting scarless healing.
Baohong Sun, Fang Han, Chunxiao Zhu, Zhiyuan Yang, Haoru Wang, Jinpei Mei, Jie Chen, Jingwen Zhu, Zihan Bo, Taju Wu, Xiaogang Zhou, Tao Ma, Yutian Su, Youhui Lin   +13 more
wiley   +1 more source

Machine learning model for early prediction of acute respiratory failure in acute pancreatitis: Multicenter validation. [PDF]

iScience
Wang Y, Lv F, Tao M, Cui J, Zhang D, Zhao H, Li J, Sun G, Wang X.   +8 more
europepmc   +1 more source