Results 181 to 190 of about 702,501 (295)

Acute kidney injury in immunocompromised patients with acute respiratory failure: insights from the HIGH clinical trial and relation with mechanical ventilation. [PDF]

Ann Intensive Care
Joseph A, Darmon M, Argaud L, Klouche K, Barbier F, Canet E, Louis G, Demoule A, Girault C, Jaber S, Lebert C, Pène F, Lemiale V, Azoulay E.   +13 more
europepmc   +1 more source

Proteolysis-induced pathomechanisms in acute inflammation and related therapeutic approaches [PDF]

, 1991
A Billing, A Billing, B Blauhut, C Gippner-Steppert, D Inthorn, D Nast-Kolb, H Hoffmann, H Vinazzer, I Assfalg-Machleidt, I Schraufstatter, JI Weitz, K-H Duswald, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Jochum, M Siebeck, M Siebeck, M Spannagl, MD Wewers, RE Jordan, S Idell, S Neumann, TE Emerson, U Obertacke, YT Wachtfogel, YT Wachtfogel   +30 more
core   +1 more source

ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy

Advanced Science, EarlyView.
A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou, Qiming Zhai, Zhihao Yao, Qing Li, Yan Yang, Si Wang, Chao Huang, Liangjing Xin, Tao Chen, Jinlin Song   +9 more
wiley   +1 more source

Dynamic chest radiography for wheezing-associated acute respiratory failure: 4 case reports. [PDF]

Radiol Case Rep
Miyatake H, Toshimitu M, Nakano S, Shimizu J, Tsujita Y, Asada K, Shiomi N.   +6 more
europepmc   +1 more source

Orthogonal Ionic Liquid‐Based Extraction Strategy Enables Amyloid‐Specific Profiling of Aggregate Proteome

Advanced Science, EarlyView.
An orthogonal ionic‐liquid extraction (Orth‐iEA) enables selective isolation of amyloid fibrils. TMGBF4 disrupts hydrogen‐bonded β‐sheet networks to solubilize amyloid aggregates, whereas C12ImCl interacts with hydrophobic regions of non‐amyloid proteins.
Shiying Zheng, Ye Liu, Bowen Zhong, Huiying Chu, Zhou Gong, Baofeng Zhao, Mengchun Cheng, Zhen Liang, Yukui Zhang, Qun Zhao, Lihua Zhang   +10 more
wiley   +1 more source

A Silent Threat: Acute Respiratory Failure and Os Odontoideum in a Child With Down's Syndrome. [PDF]

Cureus
Pasku D, Masarwa R, Bhanushali AK, Najjar E, Nocun W, D'Aquino D.   +5 more
europepmc   +1 more source

Tetrahedral DNA Nanostructure‐Based Biomimetic Nanovesicles Attenuate Sepsis‐Associated ARDS by Suppressing Glycolysis via the BMAL1/PFKFB3 Axis

Advanced Science, EarlyView.
Upon inhalation, RM@TNT could persist long‐term in the diseased lungs, while undergoing disintegration to release TNT specifically within the ROS‐rich pathological microenvironments of SA‐ARDS. The released TNT was then precisely delivered to AMs via Tuftsin, where it released Nob intracellularly to activate BMAL1 expression, thus inhibiting AM ...
Yunlong Zhang, Bin Li, Zhijin Fan, Yan Yan, Fei Ma, Changting He, Shiping Liu, Mingliang Pan, Zhou Pan, Huijuan Wang, Xinting Fu, Jiamei Wang, Yue Jia, Qin Gu, Duo Jiang, Xueting Liu, Bohua Ren, Qinqin Wang, Yuehua Hei, Han Duan, Yanqiu Wu, Zihui Wei, Liying Zhan, Yuhui Liao   +23 more
wiley   +1 more source

Metabolomic biomarkers predict long-term physical function in survivors of acute respiratory failure. [PDF]

Respir Res
Haastrup AI, Roberts JT, Gandotra S, Hartsell EM, Daly GT, Pastukh VM, Purcell LD, Benton RG, Files DC, Stevens T, Gillespie MN, Morris PE, Langley RJ.   +12 more
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source