Results 61 to 70 of about 4,323,505 (305)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Viruses and Acute Respiratory Infections

BMJ, 1965
The most common infectious diseases in Western urban communities are acute infections of the respiratory tract, and most of these are because of viruses. The viruses enter the ciliated and other cells lining the respiratory tract, multiplying there and damaging the cells.
openaire   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Acute respiratory infection - Secretion of secretory IgA

, 2016
Covers aspects of acute respiratory infections (ARI) in young children in developing countriesEducação Superior::Ciências da Saúde::MedicinaEducação Superior::Ciências da Saúde ...
Topics in international Health Acute Respiratory Infection CD-ROM, the wellcome Trust
core   +1 more source

Severe lower respiratory tract infection in early infancy and pneumonia hospitalizations among children, Kenya. [PDF]

, 2013
Severe lower respiratory tract infection (LRTI) in infants caused by respiratory syncytial virus (RSV) has been associated with later pneumonia hospitalization among children.
Eric O. Ohuma, Nokes, D. James, Ngama, Mwanajuma, Patrick Kiio Munywoki, Scott, J Anthony G, Ohuma, Eric O., Munywoki, Patrick Kiio, J. Anthony G. Scott, Bauni, Evasius, Mwanajuma Ngama, Scott, J. Anthony G., Nokes, D James, Ohuma, Eric O, Evasius Bauni, D. James Nokes   +14 more
core   +1 more source

Virus detection among cases of acute respiratory infection (ARI) and severe acute respiratory infection (SARI), India 2016–2018.

, 2022
Virus detection among cases of acute respiratory infection (ARI) and severe acute respiratory infection (SARI), India 2016–2018.
Siddhartha Saha (734497), Dipankar Biswas (734500), K. Kaveri (14059398), Aslesh Ottapura Prabhakaran (14059395), Santosh Jadhav (6729725), Parvaiz Koul (6660503), Varsha Potdar (3243867), Mandeep Chadha (336230), Chawla Sarkar Mamta (14059401), Manohar Lal Choudhary (13760878), Lalit Dar (734499), Kayla Laserson (287607), Sumit Dutt Bhardwaj (14059404)   +12 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source