Results 151 to 160 of about 1,385,174 (349)

Transmission dynamics of the etiological agent of SARS in Hong Kong: impact of public health interventions.

, 2003
We present an analysis of the first 10 weeks of the severe acute respiratory syndrome (SARS) epidemic in Hong Kong. The epidemic to date has been characterized by two large clusters-initiated by two separate "super-spread" events (SSEs)-and by ongoing ...
Lee, Koon-Hung, Leung, Gabriel M, Leung, Pak-Yin, Lau, Edith MC, Ghani, Azra C, Ho, Lai-Ming, Anderson, Roy M, Chan, King-Pan, Riley, Steven, Ho, William, Lo, Su-Vui, Hedley, Anthony J, Donnelly, Christl A, Chau, Patsy, Abu-Raddad, Laith J, Tsang, Thomas, Thach, Thuan Q, Lam, Tai-Hing, Ferguson, Neil M, Fraser, Christophe   +19 more
core   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Global prevalence and case fatality rate of Enterovirus D68 infections, a systematic review and meta-analysis

PLoS Neglected Tropical Diseases, 2022
A substantial amount of epidemiological data has been reported on Enterovirus D68 (EV-D68) infections after the 2014 outbreak. Our goal was to map the case fatality rate (CFR) and prevalence of current and past EV-D68 infections.
Amary Fall, Sebastien Kenmoe, Jean Thierry Ebogo-Belobo, Donatien Serge Mbaga, Arnol Bowo-Ngandji, Joseph Rodrigue Foe-Essomba, Serges Tchatchouang, Marie Amougou Atsama, Jacqueline Félicité Yéngué, Raoul Kenfack-Momo, Alfloditte Flore Feudjio, Alex Durand Nka, Chris Andre Mbongue Mikangue, Jean Bosco Taya-Fokou, Jeannette Nina Magoudjou-Pekam, Efietngab Atembeh Noura, Cromwel Zemnou-Tepap, Dowbiss Meta-Djomsi, Martin Maïdadi-Foudi, Ginette Irma Kame-Ngasse, Inès Nyebe, Larissa Gertrude Djukouo, Landry Kengne Gounmadje, Dimitri Tchami Ngongang, Martin Gael Oyono, Cynthia Paola Demeni Emoh, Hervé Raoul Tazokong, Gadji Mahamat, Cyprien Kengne-Ndé, Serge Alain Sadeuh-Mba, Ndongo Dia, Giuseppina La Rosa, Lucy Ndip, Richard Njouom   +33 more
doaj  

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

Acute respiratory infection - Viral multiplication cycle

, 2016
Covers aspects of acute respiratory infections (ARI) in young children in developing countriesEducação Superior::Ciências da Saúde::MedicinaEducação Superior::Ciências da Saúde ...
Topics in International Health Acute Respiratory Infection CD-ROM, The Wellcome Trust
core   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Are patient views about antibiotics related to clinician perceptions, management and outcome? A multi-country study in outpatients with acute cough

, 2013
Background: outpatients with acute cough who expect, hope for or ask for antibiotics may be more unwell, benefit more from antibiotic treatment, and be more satisfied with care when they are prescribed antibiotics.
Francis, N.K., Hasse Melbye, Butler, Christopher, GRACE Project Group, Little, P, Verheij, Theo J. M., Francis, N., Nick Francis (475899), Verheij, Theo J.M., Samuel Coenen (397250), Paul Little (475903), Butler, C.C., Goossens, Herman, Nuttall, Jacqui, Kelly, M., Mark Kelly, Little, P., Melbye, H., Goossens, H., Samuel Coenen, Hasse Melbye (475905), Melbye, H, Jacqui Nuttall, Kelly, Mark, Melbye, Hasse, Paul Little, Kerenza Hood, Herman Goossens, Mark Kelly (475900), Herman Goossens (305529), Nuttall, J, Nuttal, Jacqui, Butler, Christopher C., Goossens, H, Hood, K., Little, Paul, Coenen, S, Grace Project Group, x, Jacqui Nuttall (475902), Theo J M Verheij, Verheij, T.J., Theo J. M. Verheij (475904), Verheij, TJ, Francis, Nicholas, Coenen, S., Nuttall, J., Francis, Nick, Nick Francis, Hood, K, Coenen, Samuel, Christopher C Butler, Kerenza Hood (475901), Christopher C. Butler (475906), Kelly, M, Verheij, Th.J.M., Francis, N, Kelly, M.J., Hood, Kerenza, Butler, CC   +58 more
core   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source