Results 171 to 180 of about 850,976 (303)

MVP Inhibits Influenza A Virus‐Induced Ferroptosis by Targeting IRF1 and Increasing FSP1 Activity

Advanced Science, EarlyView.
During IAV infection, MVP inhibits IRF1 polyubiquitination, thereby relieving IRF1‐mediated transcriptional inhibition of FSP1. Consequently, this leads to an upregulation of FSP1 expression, thereby reinforcing the inhibition of ferroptosis. In addition, the MVP can promote myristoylation and ubiquitination of FSP1, enabling its membrane localization ...
Yingbo Chen, Paili Lin, Yongfang Xia, Zhiqiang Liu, Zilu Cheng, Qingmei Zhu, Shiqi Wan, Xiaoyu Chen, Haiyan Bao, Renbo Qiao, Gechang Zhong, Ying Zhu, Shi Liu   +12 more
wiley   +1 more source

The Burden of Acute Respiratory Infections on Emergency Departments: A Retrospective Study From a University Hospital in Central Italy. [PDF]

Health Sci Rep
Zotti N, Di Serafino F, Carmisciano L, Baglietto L, Cristofano M, Foltran F, Paolilli O, Porretta AD, Arzilli G, Pistello M, Rizzo C.   +10 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Correction: Surveillance of respiratory viruses in severe acute respiratory infections in Southern Brazil, 2023-2024. [PDF]

BMC Infect Dis
Ruivo AP, da Cruz Bauermann M, Gregianini TS, Dos Santos FM, Godinho F, Baethgen LF, Machado TRM, Martins LG, Mondini RP, Port CN, Correa A, Selayaran T, Resende PC, da Luz Wallau G, Salvato RS, da Veiga ABG.   +15 more
europepmc   +1 more source

Endogenous Ceramide 24:1 Constrains Th17‐Driven Neutrophilic Inflammation by Antagonizing EP2 Signaling

Advanced Science, EarlyView.
Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu, Abudureyimujiang Aili, Zheng Kuang, Liting Cao, Zemin Li, Ying Shang, Yingying Ge, Tingting Hu, Yongchang Sun, Wuli Zhao, Rong Jin, Chun Chang   +11 more
wiley   +1 more source

Epidemiology of severe acute respiratory infections in South Korea: a nationwide surveillance study. [PDF]

BMC Pulm Med
Kang DH, Kim SY, Ju H, Lee S, Lee YS, Moon JY, Kim DK, Choi HR, Rhee JE, Lee SI.   +9 more
europepmc   +1 more source

Primary care summary of the British Thoracic Society Guidelines for the management of community acquired pneumonia in adults:2009 update. Endorsed by the Royal College of General Practitioners and the Primary Care Respiratory Society UK [PDF]

, 2010
,, Le Jeune, Ivan, Levy, Mark L, Lim, Wei Shen, Macfarlaned, John T, Woodhead, Mark A   +5 more
core   +1 more source

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source

Burden and risk factors of influenza-associated acute respiratory infections among older adults in India: a multicentric community-based surveillance (2018-2023). [PDF]

Lancet Reg Health Southeast Asia
Rajkumar P, Chethrapilly Purushothaman GK, Amarchand R, Prabhakaran AO, Kumar R, Kanungo S, Bhardwaj SD, Potdar V, Chakrabarty AK, Choudekar A, Vinoth M, Parameswaran GG, Bhattacharya U, Ghuge R, Mohanraj M, Dhakad S, Choudhary A, Boopathi K, Harish P, Malik P, Shanmugasundaram P, Sarda K, Babu NK, Chakrabarty P, Priya SB, Hindupur A, Lafond K, Azziz-Baumgartner E, Tan KR, Saha S, Dar L, Krishnan A.   +31 more
europepmc   +1 more source

Plant Genetic Engineering: Technological Pathways, Application Scenarios, and Future Directions

Advanced Science, EarlyView.
This review maps the fast‐evolving landscape of plant genetic engineering, linking enabling platforms with trait‐focused applications in architecture optimization, stress resilience, yield improvement, and quality enhancement. It highlights how genome editing, transgenic strategies, and emerging multi‐gene approaches reshape breeding pipelines, while ...
Peilin Wang, Wenzhi Wang, Dongjiao Wang, Qibin Wu, Youxiong Que   +4 more
wiley   +1 more source