Results 191 to 200 of about 623,505 (258)

SCTR–Expressing Astrocyte–Serotonergic Neuron Signaling Drives Sexual Dimorphism in Depression Through KAT7/H4ac–Foxc2 Epigenetic Axis in an AMPK‐Dependent Manner

Advanced Science, EarlyView.
Astrocytic SCTR modulates depressive‐related phenotypes via AMPKα1, whereas lowered Mt1 blunts Megalin‐dependent AMPKα2 signaling in serotonergic neurons. Diminished AMPKα2 hinders KAT7 nuclear translocation, curtails KAT7 occupancy and H4K8ac at the Foxc2 promoter, and represses Foxc2 transcription, revealing cell‐type‐specific AMPK‐linked epigenetic ...
Fantao Meng, Jing Liu, Juanjuan Dai, Min Wu, Wentao Wang, Mengdi Zhang, Shujun Jiang, Yifan Cao, Lihong Xu, Lin Du, Dan Wang, Di Zhao, Gaofeng Qin, Dong Wang, Wei Li, Chen Li   +15 more
wiley   +1 more source

Viral spectrum differences between outpatients and inpatients with suspected pediatric acute respiratory infections: a prospective sentinel surveillance study in Pudong, Shanghai, China. [PDF]

BMC Infect Dis
Chen Z, Zhang X, Zhang L, Ye C, Shen Y, Wu R, Zhao B, Hao L.   +7 more
europepmc   +1 more source

Versatile Microgel Platform for Intervertebral Disc Degeneration Therapy: Targeting Pericyte‐Mediated Fibrosis and Protecting Nucleus Pulposus Cells

Advanced Science, EarlyView.
The engineered MMS@TRP microgel enables targeted, acid‐responsive delivery of a miR‐21 inhibitor to pericytes. It effectively suppresses disc fibrosis by inhibiting TGF‐β signaling while protecting nucleus pulposus cells via sustained, antioxidant tannic acid release.
Fei Ma, Zhen Zhao, Chuan Guo, Yuheng Liu, Yu Wang, Dengbo Yao, Weiqiang Lan, Dejun Zhong, Chen Fan, Yao He, Mei Zhang, Qingquan Kong, Yunfeng Lin   +12 more
wiley   +1 more source

Acute Respiratory Infections Due to Antibiotic-nonsusceptible <i>Streptococcus pneumoniae</i> in US Adults. [PDF]

Open Forum Infect Dis
King LM, Andrejko KL, Kobayashi M, Xing W, Cohen AL, Lewnard JA.   +5 more
europepmc   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Longitudinal Study of Subsequent Wheezing/Asthma Risk Among Children Hospitalized for Acute Respiratory Infections - Yichang City, Hubei Province, China, 2017-2024. [PDF]

China CDC Wkly
Qin Q, Wang Q, Wang S, Wang L, Sun J, Li G.   +5 more
europepmc   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

Surveillance of respiratory viruses in severe acute respiratory infections in Southern Brazil, 2023-2024. [PDF]

BMC Infect Dis
Ruivo AP, da Cruz Bauermann M, Gregianini TS, Dos Santos FM, Godinho F, Baethgen LF, Machado TRM, Martins LG, Mondini RP, Port CN, Correa A, Selayaran T, Resende PC, da Luz Wallau G, Salvato RS, da Veiga ABG.   +15 more
europepmc   +1 more source

Burden and risk factors of influenza-associated acute respiratory infections among older adults in India: a multicentric community-based surveillance (2018-2023). [PDF]

Lancet Reg Health Southeast Asia
Rajkumar P, Chethrapilly Purushothaman GK, Amarchand R, Prabhakaran AO, Kumar R, Kanungo S, Bhardwaj SD, Potdar V, Chakrabarty AK, Choudekar A, Vinoth M, Parameswaran GG, Bhattacharya U, Ghuge R, Mohanraj M, Dhakad S, Choudhary A, Boopathi K, Harish P, Malik P, Shanmugasundaram P, Sarda K, Babu NK, Chakrabarty P, Priya SB, Hindupur A, Lafond K, Azziz-Baumgartner E, Tan KR, Saha S, Dar L, Krishnan A.   +31 more
europepmc   +1 more source

A lifestyle-driven inflammatory load index and its circulating metabolomic signature identify susceptibility to hospital-recorded acute respiratory infections: a population-based cohort study of 295,679 adults. [PDF]

Front Endocrinol (Lausanne)
Fu X, Li X, Ma X, Wu N, Ni W, Li H.
europepmc   +1 more source