Results 51 to 60 of about 486,348 (304)

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Effects of Coronavirus Disease 2019 on Prevalence of Acute Respiratory Viruses: Changes during the Pandemic

Journal of Global Infectious Diseases
Introduction: The coronavirus disease 2019 (COVID-19) pandemic may have influenced the prevalence and seasonality of acute respiratory viral infections. The aim of the study was to investigate the prevalence of all viruses causing acute viral respiratory
Yonghee Lee, Tae Su Jang, Jae Kyung Kim
doaj   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Eicosanoids and Respiratory Viral Infection: Coordinators of Inflammation and Potential Therapeutic Targets

Mediators of Inflammation, 2012
Viruses are frequent causes of respiratory infection, and viral respiratory infections are significant causes of hospitalization, morbidity, and sometimes mortality in a variety of patient populations.
Mary K. McCarthy, Jason B. Weinberg
doaj   +1 more source

The Spread of RS-virus Infection and other ARVI not Influenza Etiology in Children and Adults in the Regions of Russia from 2014 to 2016

Эпидемиология и вакцинопрофилактика, 2018
Relevance. Respiratory syncytial virus (RSV) is the leading viral cause of acute lower respiratory tract infections in infants and young children in whom this virus is the cause of the primary  infection. Goal. The aim of the study is to study the spread
L. S. Karpova, E. A. Smorodintseva, T. J. Sysoeva, T. P. Stolyarova, N. M. Popovtseva, K. A. Stolyarov, D. M. Danilenko, L. M. Tsybalova   +7 more
doaj   +1 more source

A prospective one-year microbiologic survey of combined pneumonia and respiratory failure [PDF]

, 2017
Background: Pneumonia and respiratory failure are common problems in the intensive care unit (ICU) setting, often occurring together. The relative prevalence of pneumonia types (community acquired, hospital acquired, ventilator associated) and causative ...
Fisher, Kristen, Juang, Paul, Kollef, Marin H, Micek, Scott T, Trupka, Tracy   +4 more
core   +2 more sources

Acute respiratory viral infections in children

Russian Family Doctor, 2019
Acute respiratory viral infections in children lead in the structure of child morbidity. The defeat of the upper respiratory tract accompanied by fever and impaired general condition, the main symptoms of acute respiratory viral infections. Diagnosis of most acute respiratory viral infections is based on the assessment of clinical manifestations and ...
openaire   +2 more sources

Spinal Cord Infarction Versus Idiopathic Transverse Myelitis: Clinical, Radiological, and Functional Insights From a Retrospective Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Spinal cord infarction (SCI) is a rare but devastating myelopathy, characterized by a high disability rate and an unfavorable prognosis. It has often been underdiagnosed and misdiagnosed as idiopathic transverse myelitis (ITM). This study aimed to describe the clinical features, radiological biomarkers, treatments, and functional ...
Zeqiang Ji, Jianlong Zhang, Yiming Shi, Shiyu Shan, Yang Du, Guangshuo Li, Ying Jin, Yani Zhang, Chuanying Wang, Yijun Lin, Yuhao Guo, Decai Tian, Xingquan Zhao, Tian Song   +13 more
wiley   +1 more source

Respiratory viruses in children hospitalized for acute lower respiratory tract infection in Ghana

Virology Journal, 2012
Background Acute respiratory tract infections are one of the major causes of morbidity and mortality among young children in developing countries. Information on the viral aetiology of acute respiratory infections in developing countries is very limited.
Kwofie Theophilus B, Anane Yaw A, Nkrumah Bernard, Annan Augustina, Nguah Samuel B, Owusu Michael   +5 more
doaj   +1 more source

Resolved Influenza A Virus Infection Has Extended Effects on Lung Homeostasis and Attenuates Allergic Airway Inflammation in a Mouse Model

Microorganisms, 2020
Allergic airway inflammation (AAI) involves T helper cell type 2 (Th2) and pro-inflammatory responses to aeroallergens and many predisposing factors remain elusive.
Qingyu Wu, Ilka Jorde, Olivia Kershaw, Andreas Jeron, Dunja Bruder, Jens Schreiber, Sabine Stegemann-Koniszewski   +6 more
doaj   +1 more source