Results 61 to 70 of about 388 (169)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Bilateral acute retinal necrosis with choroidal detachment

Indian Journal of Ophthalmology. Case Reports
A 42-year-old man with history of topiramate intake presented with sudden diminution of vision. He was diagnosed with bilateral panuveitis with retinitis and serous choroidal detachment, with ultrasound biomicroscopy revealing ciliary body effusion ...
Akanksha Sharma, Uday Tekchandani, Swechya Neupane, Ramandeep Singh   +3 more
doaj   +1 more source

Acute retinal necrosis secondary to Varicella Zoster Virus

IDCases, 2019
A 54 year old female presented to the ophthalmology clinic with pain and decreased vision in her left eye. No past medical history other than primary varicella zoster infection, in her childhood.
Archana Vasudevan, Christian Rojas-Moreno, Tushar Tarun   +2 more
doaj   +1 more source

Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline

Neuroprotection, EarlyView.
Schematic diagram of the experimental design and key findings of traumatic brain injury (TBI) with varying severities. Mild, moderate, and severe TBI were induced in the right motor cortex of mice using the controlled cortical impact (CCI) method, with impact depths of 0.5, 1.0, and 2.0 mm, respectively. A subset of severe TBI mice received minocycline
Yan Yu, Chen Wang, Jinyu Zhu, Jiahui Du, Hao Li, Shuyi Ning, Rui Yang, Yiwen Ma, Mengyuan Yuan, Wei Shen, Huailin Wang, Huihui Jiang, Liping Chen, Haitao Wu   +13 more
wiley   +1 more source

Bilateral acute retinal necrosis-A case report

Indian Journal of Ophthalmology, 1992
A 42 year old man presented with acute bilateral uveitis and necrotizing retinitis. Systemic investigations including test for AIDS and CMV retinitis were negative.
Prasad Palimar, Upadhyaya N
doaj  

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Valacyclovir in the treatment of acute retinal necrosis

BMC Ophthalmology, 2012
Background To report the outcome of oral valacyclovir as the sole antiviral therapy for patients with acute retinal necrosis (ARN). Methods This study reports a retrospective, interventional case series of nine consecutive patients with ten eyes with ...
Taylor Simon RJ, Hamilton Robin, Hooper Claire Y, Joshi Lavnish, Morarji Jiten, Gupta Nitin, Lightman Sue L   +6 more
doaj   +1 more source

Nanomaterials' Multigenerational Effects by Single and Joint Exposure in Non‐mammalian Models

Environmental Toxicology, EarlyView.
ABSTRACT Nanotoxicology has mainly focused on single‐generation studies, leaving multigenerational toxicity underexplored. Having animal welfare recently gained importance, we aimed to provide the state‐of‐the‐art of knowledge about multigenerational effects in non‐mammalian models in the case of nanomaterials (NM) single and joint exposure to other ...
Andy Joel Taipe Huisa, Analía Ale, Azael Francisco Silva Neto, Lorena De Mendonça Lucena, Marcelo Estrella Josende, Milena Ferreira de Lima, Rhayanny Kethylly Pereira Santos, Martín Federico Desimone, Priscila Gubert, José María Monserrat   +9 more
wiley   +1 more source

Antiviral selection in the management of acute retinal necrosis

Clinical Ophthalmology, 2009
Patrick MK Tam1, Claire Y Hooper2, Susan Lightman21Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, N.T., Hong Kong, People’s Republic of China; 2Institute of Ophthalmology ...
Patrick MK Tam, Claire Y Hooper, Susan Lightman   +2 more
doaj