Results 61 to 70 of about 4,958,209 (258)

Biologic response of animals to husbandry stress with implications for biomedical models [PDF]

, 2010
Peer-reviewedThe quality of life of animals is defined by a range of parameters including health, physiology, and behavior. Stress is defined as any damaging strain, force, or agent which stimulates a physiologic defense reaction and is capable under ...
Buckham-Sporer, Kelly, Pang, Wanyong, Gupta, Sandeep, Earley, Bernadette, Ting, Simon   +4 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Understanding the role of early life trauma in the neuroendocrine dysregulation of youth depression

European Journal of Psychotraumatology, 2012
Background : To date there are inconsistent empirical findings regarding the nature of hypothalamic–pituitary–adrenal (HPA)-axis dysregulation in depressed youth.
Kate Ryan Kuhlman, Nestor L. Lopez-Duran
doaj   +1 more source

A non-randomized pilot trial of the use of prazosin in the prevention of transition from acute stress disorder to post-traumatic stress disorder

European Journal of Psychotraumatology, 2023
Background: Following a traumatic event, 40–80% of the patients with acute stress disorder (ASD) will develop post-traumatic stress disorder (PTSD), 67% at 6 months.
Charline Magnin, Emmanuel Poulet, Laurent Fanton, Philippe Vignaud, Jerome Brunelin   +4 more
doaj   +1 more source

Occupational role stress is associated with higher cortisol reactivity to acute stress [PDF]

, 2013
We investigated whether occupational role stress is associated with differential levels of the stress hormone cortisol in response to acute psychosocial stress. Forty-three medication-free nonsmoking men aged between 22 and 65 years (mean ± SEM: 44.5 ± 2)
Kottwitz, Maria U, Wirtz, Petra H., Ehlert, Ulrike; https://orcid.org/, Semmer, Norbert K, Ehlert, Ulrike, Wirtz, Petra H, La Marca, Roberto, Semmer, Norbert K., Kottwitz, Maria U.   +8 more
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Influence of Acute Coffee Consumption on Postprandial Oxidative Stress

, 2013
Background Coffee has been reported to be rich in antioxidants, with both acute and chronic consumption leading to enhanced blood antioxidant capacity.
Trepanowski, John F., Bloomer, Richard J., Tyler M. Farney, Farney, Tyler M., John F. Trepanowski, Richard J. Bloomer   +5 more
core   +1 more source

Stressors, Appraisal of Stressors, Experienced Stress and Cardiac Response:A Real-Time, Real-Life Investigation of Work Stress in Nurses [PDF]

, 2015
Background: Stress in health care professionals may reflect both the work and appraisal of work and impacts on the individuals, their patients, colleagues and managers.Purpose: The purpose of the present study is to examine physiological and ...
Farquharson, B., Julia Allan, Marie Johnston, Martyn Jones (720171), Bell, Cheryl, Jones, Martyn C, Martyn Jones, Ian Ricketts (16669965), Marie Johnston (18271), Farquharson, Barbara, Derek Johnston, Johnston, D., Barbara Farquharson (16669962), Derek Johnston (3064002), Bell, C., Jones, M., Patricia Schofield, Jones, Martyn, Barbara Farquharson, Ricketts, I., Schofield, Patricia, Patricia Schofield (625809), Johnston, M., Cheryl Bell (16669959), Bell, Cheryl Louise, Cheryl Bell, Ian Ricketts, Johnston, Derek, Julia Allan (4991684), Allan, J., Allan, Julia, Johnston, Marie, Johnston, Derek W, Ricketts, Ian, Allan, Julia L   +34 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source