Results 81 to 90 of about 4,958,209 (258)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Epidemiology and factors associated with acute stress disorder in burned patients: a case-control study

, 2022
Introduction A burn injury is a very painful experience, with subsequent emotional problems, which have been gaining relevance to the extent that survival from burns has improved.
Cortés López, Vladimir, Velásquez Suárez, Juliana María, Paramo Duque, Lina Marcela, Cardeño Castro, Carlos Alberto, Escobar Gómez, Lina María, Ortiz Carmona, Diana Patricia, Tamayo Gómez, Alejandra, Molina Castaño, Carlos Federico   +7 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Demoralization in the Context of Differential Diagnosis of Mental States in Severely Ill Patients with Hazard of Death

Национальный психологический журнал
Background. Timely and accurately conducted introduction of demoralization into the differential diagnostics make it possible to define objective and subjective factors essential to demoralization, which constitute actual psychological state of a patient.
Alexander Yu. Panfilov
doaj   +1 more source

Adiposity is associated with blunted cardiovascular, neuroendocrine and cognitive responses to acute mental stress [PDF]

, 2012
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited - Copyright @ 2012
Vivek Muthurangu, Jones, Alexander, Muthurangu Vivek, Deanfield, John E., McMillan Merlin R., Andrew M Taylor, Muthurangu, Vivek, Jones, RW, Jens C Pruessner, Steeden Jennifer A., Deanfield John E., Grzegorz T Kowalik, Taylor Andrew M., Taylor, Andrew M., Alexander Jones, Jones Alexander, Steeden, JA, Russell W Jones, Jones, Russell W., Merlin R McMillan, Muthurangu, V, Kowalik, GT, John E Deanfield, Pruessner, Jens C., Pruessner, JC, McMillan, MR, Deanfield, JE, Kowalik, Grzegorz T., Jones Russell W., Kowalik Grzegorz T., McMillan, Merlin R., Jones, A, Pruessner Jens C., Taylor, AM, Steeden, Jennifer A., Jennifer A Steeden   +35 more
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Histological and Proteomic Approaches to Assessing the Adrenal Stress Response in Common Dolphins (Delphinus delphis)

Animals
The adrenal glands are central to the stress response in cetaceans, yet their morphological and molecular changes under chronic stress remain poorly described.
Claudia Medina Santana, Orla Slattery, Jim O’Donovan, Sinéad Murphy   +3 more
doaj   +1 more source