Results 91 to 100 of about 4,986,959 (302)

Acute and chronic toxicity of a polyherbal preparation – Jueyin granules

BMC Complementary and Alternative Medicine, 2018
Background The potential toxicity of Chinese herbal medicine has attracted more attention in recent years. Jueyin granules (JYG), a polyherbal formula, have been proven to be an effective agent for treating psoriasis in both animal models and clinical ...
Yu Chen, Dong-jie Guo, Hui Deng, Min-feng Wu, Ya-Nan Zhang, Su Li, Rong Xu, Jie Chen, Xing-xiu Jin, Bin Li, Qi Xu, Fu-lun Li   +11 more
doaj   +1 more source

ProTox-II: a webserver for the prediction of toxicity of chemicals

Nucleic Acids Res., 2018
Advancement in the field of computational research has made it possible for the in silico methods to offer significant benefits to both regulatory needs and requirements for risk assessments, and pharmaceutical industry to assess the safety profile of a ...
Priyanka Banerjee, Andreas Eckert, Anna K. Schrey, R. Preissner   +3 more
semanticscholar   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Acute, subacute, and sub‐chronic toxicity evaluation of Bletilla formosana tubers in rats

Food Safety and Health
Bletilla formosana (Hayata) Schltr. is an important economic medicinal and edible plant in China. Its tubers (BFTs) are traditionally consumed as a beverage and canned foods for promoting human health.
Yongchao Wang, Jian Zhang, Tianrui Zhao, Jianxin Cao, Afsar Khan, Zhengxuan Wang, Yaping Liu, Guiguang Cheng   +7 more
doaj   +1 more source

Status of Acute Systemic Toxicity Testing Requirements and Data Uses by U.S. Regulatory Agencies

Regulatory toxicology and pharmacology : RTP, 2018
Acute systemic toxicity data are used by a number of U.S. federal agencies, most commonly for hazard classification and labeling and/or risk assessment for acute chemical exposures.
J. Strickland, A. Clippinger, Jeffrey Brown, D. Allen, A. Jacobs, J. Matheson, A. Lowit, Emily N. Reinke, Mark S. Johnson, M. Quinn, D. Mattie, S. Fitzpatrick, S. Ahir, N. Kleinstreuer, W. Casey   +14 more
semanticscholar   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Integrating genetic polymorphisms and clinical data to develop predictive models for skin toxicity in breast cancer radiation therapy

Breast
Background: We aim to develop and validate predictive models for acute and late skin toxicity in breast cancer (BC) patients undergoing radiation therapy (RT).
Ester Aguado-Flor, Victoria M. Reyes, Víctor Navarro, Meritxell Mollà, Miguel E. Aguado-Barrera, Manuel Altabas, David Azria, Adinda Baten, Celine Bourgier, Renée Bultijnck, Jenny Chang-Claude, Maria Carmen De Santis, Alison M. Dunning, Laura Duran-Lozano, Rebecca M. Elliott, Marie-Pierre Farcy Jacquet, Carlotta Giandini, Alexandra Giraldo, Sheryl Green, Maarten Lambrecht, Carlos Lopez-Pleguezuelos, Chris Monten, Tiziana Rancati, Tim Rattay, Barry S. Rosenstein, Dirk De Ruysscher, Orland Diez, Petra Seibold, Elena Sperk, R Paul Symonds, Hilary Stobart, Ana Vega, Liv Veldeman, Guillermo Villacampa, Adam J. Webb, Caroline Weltens, Paolo Zunino, Christopher J. Talbot, Catharine M. West, Jordi Giralt, Sara Gutiérrez-Enríquez   +40 more
doaj   +1 more source

Antimicrobial evaluation, acute and sub-acute toxicity studies of Allium sativum

, 2016
Objective To evaluate the antimicrobial and toxicological effects of aqueous garlic (Allium sativum) bulbs extract in wister rat using biochemical and hematological parameters.
B. Lawal, O. Shittu, F. Oibiokpa, Hadiza Mohammed, S. Umar, G. Haruna   +5 more
semanticscholar   +1 more source