Results 151 to 160 of about 4,781,689 (344)

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Interactions between Magnetic Nanowires and Living Cells : Uptake, Toxicity and Degradation

, 2011
We report on the uptake, toxicity and degradation of magnetic nanowires by NIH/3T3 mouse fibroblasts. Magnetic nanowires of diameters 200 nm and lengths comprised between 1 {\mu}m and 40 {\mu}m are fabricated by controlled assembly of iron oxide ({\gamma}
Armelle Baeza-Squiban, Auffan M., Berret J.-F., Brunner T. J., Cappallo N., Champion J. A., Chanteau B., Conner S. D., Denizot F., Dietrich Averbeck, Donaldson K., Doshi N., Dumortier H., Florence Niedergang, Fresnais J., Fresnais J., Fresnais J., Fung A. O., Goubault C., Gratton S. E. A., Hallstrom W., Hillaireau H., Hultgren A., Hurst S. J., Hussain S., Hélène Conjeaud, Jacquin M., Jean-François Berret, Johansson F., Kagan V. E., Kim J., Kuimova M. K., Leung K. C. F., Lewinski N., Lutz J.-F. o., Malak Safi, Marie-Alice Guedeau-Boudeville, Massart R., Minhao Yan, Nan A. J., Nicole Boggetto, Niedergang F., Petri-Fink A., Pisanic T. R., Rad A. M., Safi M., Sehgal A., Singh H., Singh N., Song M. M., Tanase M., Virginie Garnier-Thibaud   +51 more
core   +3 more sources

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Acute, Subacute and Subchronic Toxicological Studies of Carissa Carandas Leaves (Ethanol Extract): A Plant Active against Cardiovascular Diseases

Journal of the Dow University of Health Sciences, 2014
Objective: The Purpose of this research study was to examine the toxicological effects of aqueous: ethanol(1:1) extract of Carissa carandas leaves extracts in rats.
Sumbul Shamim
doaj   +4 more sources

Toxicity of Radiotherapy in Patients With Collagen Vascular Disease [PDF]

, 2016
Background A diagnosis of collagen vascular disease (CVD) may predispose to radiotherapy (RT) toxicity. The objective of the current study was to identify factors that influence RT toxicity in the setting of CVD. Methods A total of 86 RT courses for 73
Abu-Isa, MD, Eyad, Ben-Josef, MD, Edgar, Griffith, MPH, MS, Kent A., Lin, MD, Alexander   +3 more
core   +1 more source

Acute and Subacute Toxicity of Cyclohexene in Rats [PDF]

, 1995

openalex   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The folic acid antagonists and their use is the treatment of acute leukemia [PDF]

, 1954
Thesis (M.D.)--Boston ...
Boyd, George K.
core