Results 171 to 180 of about 56,112 (236)

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka   +12 more
wiley   +1 more source

Additive Value of Pyridostigmine to Silodosin in the Management of Acute Urinary Retention Secondary to Benign Prostatic Hyperplasia: A Randomized Controlled Trial. [PDF]

open access: yesJ Clin Med
Mohamed AG   +10 more
europepmc   +1 more source

Patient‐ and Clinician‐Related Factors Associated With the Reduction in Opioid Use Among Adults With Chronic Non‐Cancer Pain: A Systematic Review

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Despite known risks, opioids are widely used for chronic non‐cancer pain (CNCP). Clinical guidelines now recommend deprescribing, but factors predicting success are poorly understood. This systematic review aimed to identify clinician and patient factors associated with attaining successful opioid dose reduction or discontinuation in adults with CNCP ...
Alessandra C. Marcelo   +8 more
wiley   +1 more source

Acute Urinary Retention Secondary to Urethral Lithiasis in a 4-Year-Old Boy: How We Managed This Rare Case. [PDF]

open access: yesEuropean J Pediatr Surg Rep
Planchamp T   +7 more
europepmc   +1 more source

Dried biofluid droplet morphologies for automated and scalable disease classification

open access: yesDroplet, EarlyView.
For the first time, disease‐specific fingerprints of diabetes and influenza are revealed from dried biofluid droplet morphologies. Using automated droplet detection, texture analysis, and interpretable machine learning, this scalable workflow transforms endpoint droplet patterns into diagnostic biomarkers for point‐of‐care healthcare applications ...
Anusuya Pal   +5 more
wiley   +1 more source

Investigations Into the Human Metabolism of Trestolone (7α‐Methyl‐19‐Nortestosterone)

open access: yesDrug Testing and Analysis, EarlyView.
As the known metabolites of 7α‐methyl‐19‐nortestosterone (MENT), M1 and M2, suffer from chromatographic issues under routine doping control conditions, the human metabolism of MENT was reinvestigated. From the numerous new metabolites detected, especially, M5 and M10 were identified as the most promising candidates to be implemented into routine ...
Thomas Piper   +2 more
wiley   +1 more source

Annual Banned‐Substance Review 18th Edition—Analytical Approaches in Human Sports Drug Testing 2024/2025

open access: yesDrug Testing and Analysis, EarlyView.
New insights into drug metabolism, distribution, elimination, and detection assays for drugs and methods of sports doping published between 2024 and 2025 are critically reviewed and evaluated in context with the Prohibited List 2025 as established by the World Anti‐Doping Agency.
Mario Thevis, Tiia Kuuranne, Hans Geyer
wiley   +1 more source

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