Results 181 to 190 of about 3,035,557 (301)

Cutaneous Adverse Drug Reactions Associated With BRAF and MEK Inhibitors: A Real‐World Analysis of WHO Pharmacovigilance Data

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 274-285, July 2026.
BRAF inhibitors and MEK inhibitors (MEKi) have reshaped the treatment of BRAFV600‐mutant malignancies; however, cutaneous adverse drug reactions (ADRs) remain a frequent and clinically impactful toxicity. Although clinical trials provide insight into their safety profiles, real‐world data on dermatologic ADRs are limited.
Natalia Sauer, Piotr Giedziun, Jacek Calik, Anna Wiela‐Hojeńska   +3 more
wiley   +1 more source

Insects and Survival: A Review of Primary and Secondary Defense Strategies

Entomologia Experimentalis et Applicata, Volume 174, Issue 7, Page 601-624, July 2026.
Based on a review of three decades of literature, insect defense mechanisms are classified into primary (I) and secondary (II) mechanisms of behavioral, morphological, and chemical nature. These mechanisms have been recorded in 22 (I) and 20 (II) orders, respectively.
Lucas Fernandes Silva, Rodrigo Almeida Pinheiro, José Cola Zanuncio, Conceição Aparecida dos Santos   +3 more
wiley   +1 more source

Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria: A Randomized Double‐Blind Clinical Trial

Annals of Emergency Medicine, 2018
C. Barniol, É. Dehours, J. Mallet, Charles-Henri Houze-Cerfon, D. Lauque, S. Charpentier   +5 more
semanticscholar   +1 more source

An Autoethnography of My Experiences of Undergoing Fertility Treatment While Working as an Academic

Gender, Work &Organization, Volume 33, Issue 4, Page 1405-1415, July 2026.
ABSTRACT In this paper, I provide an autoethnographic account of my experiences of undergoing fertility treatment while working in a higher education institution in the United Kingdom. My autoethnographic reflections are situated in the context of neoliberal academia, characterized by high pressures to perform. Despite the prevalence of infertility and
Samantha Wilkinson
wiley   +1 more source

Do Laboratory‐Reared Flies Perform Differently as Pollinators? Morphology, Behaviour and Pollination Performance of Eristalis tenax (Syrphidae)

Journal of Applied Entomology, Volume 150, Issue 6, Page 716-727, July 2026.
ABSTRACT Flies (Diptera) are important pollinators in global agriculture, yet little is known about how intraspecific trait variation influences their pollination performance. We compared morphological traits, foraging behaviour and pollination‐related performance metrics between laboratory‐reared (hereafter lab‐reared) and wild populations of ...
Abby E. Davis, Lena Alice Schmidt, Karen C. B. S. Santos, Samantha Harrington, Raylea Rowbottom, Amy Lucas, Cameron Spurr, Blake M. Dawson, Romina Rader   +8 more
wiley   +1 more source

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, Volume 13, Issue 6, Page 1268-1275, June 2026.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients With Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, Volume 78, Issue 6, Page 761-770, June 2026.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; ClinicalTrials.gov identifier ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) Network investigators   +14 more
wiley   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Chemical Markers and Bioactivity of Algerian Royal Jelly: Influence of Bee Subspecies, Geography, and Lyophilization

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Algerian royal jelly from native honey bees shows chemical diversity influenced by geography and subspecies. Lyophilization preserves key compounds, including 10‐HDA and phenolics. Biological assays reveal modest antioxidant activity and selective cytotoxicity against Reh leukemia cells, while anti‐inflammatory effects are limited.
A. S. Ayad, M. P. A. Hébert, J. A. Doiron, W. Loucif‐Ayad, T. Daas, G. Smagghe, M. Touaibia, M. E. Surette   +7 more
wiley   +1 more source

Hypokalemic Periodic Paralysis in a Young Woman With Mast Cell Activation Syndrome: A Case Report of an Atypical Presentation Associated With an Ultra‐Rare CACNA1S Variant

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Hypokalemic periodic paralysis (hKPP) is a rare neuromuscular channelopathy characterized by transient episodes of muscle weakness or paralysis associated with low serum potassium levels. It has been most commonly linked to autosomal dominant mutations in ion channel genes, specifically CACNA1S and SCN4A, which impair skeletal muscle ...
Ali Moradi, Yasmin Aboutaleb, Saba Noreen, Abdullah Sahyouni, Hasin Sharma, Olugbenga Oyesanmi, Ian M. Kahane, Yizhi Lin, Hakan R. Toka   +8 more
wiley   +1 more source