Results 121 to 130 of about 24,285 (335)
Mechanism and role of regulated cell death in tumor immunity and immunotherapy
Cancer Communications, EarlyView.Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu +4 more
wiley +1 more source
ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism
ChemBioChem, EarlyView.ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler +2 more
wiley +1 more source
Methylation of the Gpat2 promoter regulates transient expression during mouse spermatogenesis [PDF]
, 2015 Spermatogenesis is a highly regulated process that involves both mitotic and meiotic divisions, as well as cellular differentiation to yield mature spermatozoa from undifferentiated germinal stem cells.
Cattaneo, Elizabeth Renee +6 more
core +2 more sources
Reaction Engineering of In Vitro Natural Product Biosynthesis: Challenges and Strategies
ChemBioChem, EarlyView.The yield and turnover of in vitro natural product biosynthesis, and even its feasibility, are determined by intermolecular interactions. Reaction engineering allows to improve the performance of such complex biocatalytic systems. Natural products are widely used as pharmaceuticals and agrochemicals, or as active ingredients in food and cosmetics ...
Elsa Sánchez‐García +2 more
wiley +1 more source
Synthesis of neutral ether lipid monoalkyl-diacylglycerol by lipid acyltransferases[S]
Journal of Lipid Research, 2017 In mammals, ether lipids exert a wide spectrum of signaling and structural functions, such as stimulation of immune responses, anti-tumor activities, and enhancement of sperm functions.
Zhengping Ma +5 more
doaj +1 more source
Peroxisomal and mitochondrial enzymes involved in lipid metabolism : studies on function and regulation [PDF]
, 2013 Fatty acids constitute a major part of the energy that we obtain from the diet and are also the principal source for mammals to store energy. To use the incoming or stored fatty acids as energy, the fatty acids needs to be metabolized of which the ...
Tillander, Veronika
core +1 more source
ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li +12 more
wiley +1 more source
Discovery of Anthocyanin Acyltransferase1 (AAT1) in Maize Using Genotyping-by-Sequencing (GBS)
G3: Genes, Genomes, Genetics, 2018 The reduced acylation phenotype describes the inability of certain accessions of maize (Zea mays [L.]) to produce significant amounts of acylated anthocyanins, which are typically the most abundant pigments.
Michael N. Paulsmeyer +2 more
doaj +1 more source
Penicillin Acyltransferase in Penicillium chrysogenum [PDF]
, 1967 David L. Pruess, Marvin J. Johnson
openalex +1 more source
Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis
ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen +7 more
wiley +1 more source